Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: Binding mode and phosphorylation of tenofovir derivatives

Nucleosides, Nucleotides and Nucleic Acids

Volumn 28, Issue 8, 2009, Pages 776-792

  Koch, Kerstin ^a   Chen, Yuxing ^b   Feng, Joy Y ^c   Borroto Esoda, Katyna ^c   Deville Bonne, Dominique ^d   Janin, Joël ^a   Moréra, Solange ^e  

^a INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c GILEAD SCIENCES   (United States)

^d SORBONNE UNIVERSITÉ   (France)

^e LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

Nucleoside reverse transcriptase inhibitor; Nucleotide binding; Nucleotide conformation; Phosphorylation

Indexed keywords

CREATINE KINASE; NUCLEOSIDE DIPHOSPHATE KINASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR;

ARTICLE; DRUG ACTIVATION; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME SUBSTRATE; MICHAELIS CONSTANT; MOLECULAR MODEL; MUTATION; PHOSPHORYLATION; PROTEIN EXPRESSION; X RAY CRYSTALLOGRAPHY;

ADENINE; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DICTYOSTELIUM; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; NUCLEOSIDE-DIPHOSPHATE KINASE; NUCLEOTIDES; PHOSPHONIC ACIDS; PHOSPHORYLATION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 75149120144     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903155899     Document Type: Article

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