The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1

International Journal of Cancer

Volumn 126, Issue 6, 2010, Pages 1403-1416

  Mallakin, Ali ^a   Sugiyama, Takayuki ^a   Kai, Fumitake ^a   Taneja, Pankaj ^a   Kendig, Robert D ^a   Frazier, Donna P ^a   Maglic, Dejan ^a   Matise, Lauren A ^a   Willingham, Mark C ^a   Inoue, Kazushi ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Amphiregulin; Arf; Dmp1; Dmtf1; Ect2; Egr1; GeneChip microarray; Haploid insufficiency; JunB; Lung; Thrombospondin 1

Indexed keywords

ADRENOMEDULLIN; AMPHIREGULIN; CYCLIN D BINDING MYB LIKE PROTEIN 1; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PROTEIN BCL 3; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE TARGETING; GENETIC CODE; GENETIC TRANSCRIPTION; HAPLOIDY; LUNG ALVEOLUS EPITHELIUM; LUNG PARENCHYMA; MESSENGER RNA SYNTHESIS; METASTASIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EARLY GROWTH RESPONSE PROTEIN 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENE EXPRESSION PROFILING; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THROMBOSPONDIN 1; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 74949144054     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24938     Document Type: Article

References (46)

1. Hirai H, Sherr CJ. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol Cell Biol 1996;16:6457-67.
2. Sugiyama T, Frazier DP, Taneja P, Kendig RD, Morgan RL, Matise LA, Lagedrost SJ, Inoue K. Signal transduction involving the Dmp1 transcription factor and its alteration in human cancer. Clinical Medicine: Oncology 2008;2:209-19.
3. Sugiyama T, Frazier DP, Taneja P, Morgan RL, Willingham MC, Inoue K. The role of Dmp1 and its future in lung cancer diagnostics. Expert Rev Mol Diagn 2008;8:435-48.
4. Inoue K, Sherr CJ. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol Cell Biol 1998;18:1590-600.
5. Inoue K, Sherr CJ, Shapiro LH. Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. J Biol Chem 1998;273:29188-94.
6. Inoue K, Roussel MF, Sherr CJ. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proc Natl Acad Sci USA 1999;96:3993-8.
7. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005;41:2462-78. Review.
8. Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF, Sherr CJ. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev 2000;14:1797-809.
9. Mallakin A, Taneja P, Matise LA, Willingham MC, Inoue K. Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs. Oncogene 2006;25:7703-13.
10. Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Mol Cell Biol 2005;25:220-32.
11. Taneja P, Mallakin A, Matise LA, Frazier DP, Choudhary M, Inoue K. Repression of Dmp1 and the Arf transcription by anthracyclins: critical roles of the NF-κB subunit p65. Oncogene 2007;26:7457-66.
12. Tschan MP, Gullberg U, Shan D, Torbett BE, Fey MF, Tobler A. The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Leukemia 2008;22:1087-90.
13. Inoue K, Zindy F, Randle DH, Rehg JE, Sherr CJ. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev 2001;15:2934-9.
14. Mallakin A, Sugiyama T, Taneja P, Matise LA, Frazier DP, Choudhary M, Hawkins GA, D'Agostino RB Jr, Willingham MC, Inoue K. Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell 2007;12:381-94.
15. Brown PO, Botstein D. Exploring the new world of the genome with DNA microarrays. Nature Genet 1999;21:33-7.
16. Lipshutz RJ, Fodor SPA, Gingeras TR, Lockhart DJ. High density synthetic oligonucleotide arrays. Nature Genet 1999;21:20-4.
17. Mallakin A, Kutcher LW, McDowell SA, Kong S, Schuster R, Lentsch AB, Aronow BJ, Leikauf GD, Waltz SE. Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol 2006;34:15-27.
18. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 1996;14:1675-80.
19. Kammouni W, Ramakrishna G, Sithanandam G, Smith GT, Fornwald LW, Masuda A, Takahashi T, Anderson LM. Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence. Cell Growth Differ 2002;13:441-8.
20. Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, MacLean KH, Chung L, Yang C, Spruck C, Boyd K, Reed SI, Cleveland JL. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J 2007;26:2562-74.
21. Polosa R, Prosperini G, Leir SH, Holgate ST, Lackie PM, Davies DE. Expression of c-erbB receptors and ligands in human bronchial mucosa. Am J Respir Cell Mol Biol 1999;20:914-23.
22. Schuger L, Johnson GR, Gilbride K, Plowman GD, Mandel R. Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation. Development 1996;122:1759-67.
23. Shoyab M, McDonald VL, Bradley JG, Todaro G. Amphiregulin, a bifunctional growth-stimulating glycoprotein produced by the phorbol 12-myristate 13 acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci USA 1988;85:6528-32.
24. Sun M, Behrens C, Feng L, Ozburn N, Tang X, Yin G, Komaki R, Varella-Garcia M, Hong WK, Aldape KD, Wistuba II. HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res 2009;15:4829-37. Epub 2009 Jul 21.
25. Masago K, Fujita S, Hatachi Y, Fukuhara A, Sakuma K, Ichikawa M, Kim YH, Mio T, Mishima M. Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer. Cancer Sci 2008;99:2295-301. Epub 2008 Sep 22.
26. Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest 1998;101:982-92.
27. Jimenez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 2000;6:41-8.
28. Folkman J. Angiogenesis: an organizing principle for drug discovery? Nature Rev Drug Disc 2007;6:273-86.
29. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-6.
30. Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M. Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J 2000;19:2056-68.
31. Baron V, Adamson ED, Calogero A, Ragona G, Mercola D. The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther. 2006;13:115-24.
32. Ferraro B, Bepler G, Sharma S, Cantor A, Haura EB. EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer. J. Clin Oncol 2005;23:1921-26.
33. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocrine Rev 2007;21:138-67.
34. Martinez A, Miller MJ, Unsworth EJ, Siegfried JM, Cuttitta F. Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology 1995;136:4099-105.
35. Zudaire E, Martínez A, Cuttitta F. Adrenomedullin and cancer. Regul Pept 2003;112:175-83.
36. Courtois G, Gilmore TD. Mutations in the NF-kB signaling pathway: implications for human disease. Oncogene 2006;25:6831-43.
37. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008;132:344-62.
38. Martin-Subero JI, Wlodarska I, Bastard C, Picquenot JM, Höppner J, Giefing M, Klapper W, Siebert R. Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma. Blood 2006;108:401-2.
39. Boyes J, Bird A. DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 1991;64:1123-34.
40. Fujita N, Takebayashi S, Okumura K, Kudo S, Chiba T, Saya H, Nakao M. Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. Mol Cell Biol 1999;19:6415-26.
41. Meehan RR, Lewis JD, McKay S, Kleiner EL, Bird AP. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 1989;58:499-507.
42. Schneider C, King RM, Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988;54:787-93.
43. Petronczki M, Glotzer M, Kraut N, Peters JM. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell 2007;12:713-25.
44. Chalamalasetty RB, Hümmer S, Nigg EA, Silljé HH. Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. J Cell Sci 2006;119(Pt 14):3008-19.
45. Hirata D, Yamabuki T, Miki D, Ito T, Tsuchiya E, Fujita M, Hosokawa M, Chayama K, Nakamura Y, Daigo Y. Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res 2009;15:256-66.
46. Lynch CJ, Milner J. Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency. Oncogene 2006;25:3463-70.