Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence

Cell Growth and Differentiation

Volumn 13, Issue 9, 2002, Pages 441-448

  Kammouni, Wafa ^a   Ramakrishna, Gayatri ^a   Sithanandam, Gunamani ^a   Smith, George T ^a   Fornwald, Laura W ^a   Masuda, Akira ^a   Takahashi, Takashi ^a   Anderson, Lucy M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; PROTEIN P21; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; COMPLEX FORMATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ASSAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; EPITHELIAL CELLS; GRB2 ADAPTOR PROTEIN; GUANOSINE TRIPHOSPHATE; HUMANS; IMMUNOBLOTTING; LUNG; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PRECIPITIN TESTS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); TIME FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036742607     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Lowy, D. R., and Willumsen, B. M. Function and regulation of ras. Annu. Rev. Biochem., 62: 851-891, 1993.
2. Downward, J. Control of ras activation. Cancer Surveys, 27: 87-100, 1996.
3. Bos, J. L. Ras oncogenes in human cancer: a review. Cancer Res., 49: 4682-4689, 1989.
4. Mills, N. E., Fishman, C. L., Rom, W. N., Dubin, N., and Jacobson, D. R. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res., 55: 1444-1447, 1995.
5. McCormick, F. Ras oncogenes. In: R. A. Weinberg (ed.), Oncogenes and the Molecular Origin of Cancer, pp. 125-145. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
6. Yamamoto, T., Taya, S., and Kaibuchi, K. Ras-induced transformation and signaling pathway. J. Biochem., 126: 799-803, 1999.
7. Pulciani, S., Santos, E., Long, L. K., Sorrentino, V., and Barbacid, M. Ras gene amplification and malignant transformation. Mol. Cell. Biol., 5: 2836-2841, 1985.
8. Shields, J. M., Pruitt, K., McFall, A., Shaub, A., and Der, C. J. Understanding Ras: 'it ain't over 'til it's over.' Trends Cell Biol., 10: 147-154, 2000.
9. Frame, S., and Balmain, A. Integration of positive and negative growth signals during ras pathway activation in vivo. Curr. Opin. Genet. Dev., 10: 106-113, 2000.
10. Pérez-Sala, D., and Rebollo, A. Novel aspects of Ras proteins biology: regulation and implications. Cell Death Differ., 6: 722-728, 1999.
11. Malumbres, M., and Pellicer, A. RAS pathways to cell cycle control and cell transformation. Front. Biosci., 3: 887-912, 1998.
12. Blagosklonny, M. V. A node between proliferation, apoptosis, and growth arrest. Bioessays, 21: 704-709, 1999.
13. Umanoff, H., Edelmann, W., Pellicer, A., and Kucherlapati, R. The murine N-ras gene is not essential for growth and development. Proc. Natl. Acad. Sci. USA, 92: 1709-1713, 1995.
14. Ise, K., Nakamura, K., Nakao, K., Shimizu, S., Harada, H., Ichise, T., Miyoshi, J., Gondo, Y., Ishikawa, T., Alba, A., and Katsuki, M. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene, 19: 2951-2956, 2000.
15. Koera, K., Nakamura, K., Nakao, K., Miyoshi, J., Toyoshima, K., Hatta, T., Otani, H., Alba, A., and Katsuki, M. K-ras is essential for the development of the mouse embryo. Oncogene, 15: 1151-1159, 1997.
16. Olson, M. F., and Marais, R. Ras protein signalling. Semin. Immunol., 12: 63-73, 2000.
17. Yan, J., Roy, S., Apolloni, A., Lane, A., and Hancock, J. F. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem., 273: 24052-24056, 1998.
18. Voice, J. K., Klemke, R. L., Le, A., and Jackson, J. H. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J. Biol. Chem., 274: 17164-17170, 1999.
19. Thrane, E. V., Becher, R., Lag, M., Refsnes, M., Huitfeldt, H. S., and Schwarze, P. E. Differential distribution and increased levels of ras proteins during lung development. Exp. Lung Res., 23: 35-49, 1997.
20. Sithanandam, G., Ramakrishna, G., Diwan, B. A., and Anderson, L. M. Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation. Oncogene, 17: 493-502, 1998.
21. INK4a. Cell, 88: 593-602, 1997.
22. Rosales, C., O'Brien, V., Kornberg, L., and Juliano, R. Signal transduction by cell adhesion receptors. Biochim. Biophys. Acta, 1242: 77-98, 1995.
23. Lubman, R. L., Zhang, X. L., Zheng, J., Ocampo, L., Lopez, M. Z., Veeraraghavan, S., Zabski, S. M., Danto, S. I., and Borok, Z. Integrin a(3)-subunit expression modulates alveolar epithelial cell monolayer formation. Am. J. Physiol. Lung Cell. Mol. Physiol., 279: L183-L193, 2000.
24. Mulder, K. M. Role of ras and Mapks in TGFβ signaling. Cytokine Growth Factor Rev., 11: 23-35, 2000.
25. Masuda, A., Kondo, M., Saito, T., Yatabe, Y., Kobayashi, T., Okamoto, M., Suyama, M., Takahashi, T., and Takahashi, T. Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor β1. Cancer Res., 57: 4898-4904, 1997.
26. Liu, Q., Huang, S. S., and Huang, J. S. Function of the type V transforming growth factor β receptor in transforming growth factor βinduced growth inhibition of mink lung epithelial cells. J. Biol. Chem., 272: 18891-18895, 1997.
27. Jakowlew, S. B., Moody, T. W., You, L., and Mariano, J. M. Reduction in transforming growth factor-β type II receptor in mouse lung carcinogenesis. Mol. Carcinog. 22: 46-56, 1998.
28. Bottinger, E. P., Jakubczak, J. L., Haines, D. C., Bagnall, K., and Wakefield, L. M. Transgenic mice overexpressing a dominant-negative type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res., 57: 5564-5570, 1997.
29. Jakowlew, S. B., Moody, T. W., You, L., and Mariano, J. M. Transforming growth factor-β expression in mouse lung carcinogenesis. Exp. Lung Res., 24: 579-593, 1998.
30. Mouhieddine, O. B., Cazals, V., Maitre, B., Le Bouc, Y., Chadelat, K., and Clement, A. Insulin-like growth factor-II (IGF-II), type 2 IGF receptor, and IGF-binding protein-2 gene expression in rat lung alveolar epithelial cells: relation to proliferation. Endocrinol., 135: 83-91, 1994.
31. Cazals, V., Mouhieddine, B., Maitre, B., Le Bouc, Y., Chadelat, K., Brody, J. S., and Clement, A. Insulin-like growth factors, their binding proteins, and transforming growth factor-β1 in oxidant-arrested lung alveolar epithelial cells. J. Biol. Chem., 269: 14111-14117, 1994.
32. O'Dell, S. D., and Day, I. N. Insulin-like growth factor II (IGF-II). Int. J. Biochem. Cell Biol., 30: 767-771, 1998.
33. Stewart, C. E., and Rotwein, P. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol. Rev., 76: 1005-1026, 1996.
34. Schofield, P. N., Lee, A., Hill, D. J., Cheetham, J. E., James, D., and Stewart, C. Tumour suppression associated with expression of human insulin-like growth factor II. Br. J. Cancer, 63: 687-692, 1991.
35. Grimberg, A., and Cohen, P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J. Cell Physiol., 183: 1-9, 2000.
36. Kornfeld, S. Structure and function of the M6P/IGFII receptors. Ann. Rev. Biochem., 61: 307-330, 1992.
37. Souza, R. F., Wang, S., Thakar, M., Smolinski, K. N., Yin, J., Zou, T. T., Kong, D., Abraham, J. M., Toretsky, J. A. and Meltzer, S. J. Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells. Oncogene, 18: 4063-4068, 1999.
38. Kong, F. M., Anscher, M. S., Washington, M. K., Killian, J. K., and Jirtle, R. L. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene, 19: 1572-1578, 2000.
39. Takenawa, T., Miki, H., and Matuoka, K. Signaling through Grb2/Ash-control of the Ras pathway and cytoskeleton. Curr. Top. Microbiol. Immunol., 228: 325-342, 1998.
40. Wada, S., Sasaki, Y., Horimoto, M., Ito, T., Ito, Y., Tanaka, Y., Toyama, T., Kasahara, A., Hayashi, N., and Hori, M. Involvement of growth factor receptor-bound protein-2 in rat hepatocyte growth. J. Gastroenterol. Hepatol., 13: 635-642, 1998.
41. Rice, P. L., Porter, S. E., Koski, K. M., Ramakrishna, G., Chen, A., Schrump, D., Kazlauskas, A., and Malkinson, A. M. Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Mol. Carcinog., 25: 285-294, 1999.
42. Smith, G. J., Rhodes, G. C., and Moore, G. P. M. Enhanced malignant phenotype of urethane-induced lung adenoma associated with sialoadenectomy in BALB/c mice. Carcinogenesis (Lond.), 10: 1169-1173, 1989.
43. Lih, C. J., Cohen, S., Wang, C., and Lin-Chao, S. The platelet-derived growth factor α-receptor is encoded by a growth-arrest specific (gas) gene. Proc. Natl. Acad. Sci. USA, 93: 4617-4622, 1996.
44. Matsui, R., Brody, J. S., and Yu, Q. FGF-2 induces surfactant protein gene expression in foetal rat lung epithelial cells through a MAPK-independent pathway. Cell. Signal., 11: 221-228, 1999.
45. Rebollo, A., and Martinez, C. Ras proteins: recent advances and new functions. Blood, 94: 2971-2980, 1999.
46. Fan, J., and Bertino, J. R. K-ras modulates the cell cycle via both positive and negative regulatory pathways. Oncogene, 14: 2595-2607, 1997.
47. WAF1-dependent mechanism. Oncogene, 19: 783-790, 2000.
48. Lloyd, A. C. Ras versus cyclin-dependent kinase inhibitors. Curr. Opin. Genet. Dev., 8: 43-48, 1998.
49. Levine, R. A., Hopman, T., Guo, L., Chang, M. J., and Johnson, N. Induction of retinoblastoma gene expression during terminal growth arrest of a conditionally immortalized fetal rat lung epithelial cell line and during fetal lung maturation. Exp. Cell Res., 239: 264-276, 1998.
50. Re, F. C., Manenti, G., Borrello, M. G., Colombo, M. P., Fisher, J. H., Pierotti, M. A., Della Porta, G., and Dragani, T. A. Multiple molecular alterations in mouse lung tumors. Mol. Carcinog., 5: 155-160, 1992.
51. Sabourin, C. L., Wang, Q. S., Ralston, S. L., Evans, J., Coate, J., Herzog, C. R., Jones, S. L., Weghorst, C. M., Kelloff, G. J., Lubet, R. A., You, M., and Stoner, G. D. Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. Exp. Lung Res., 24: 499-521, 1998.
52. ARF, which confers selection in mouse lung tumorigenesis. Mol. Carcinog., 25: 92-98, 1999.
53. INK4a genes in the development of mouse lung tumors. Exp. Lung Res., 24, 463-479, 1998.
54. Corroyer, S., Nabeyrat, E., and Clement, A. Involvement of the cell cycle inhibitor CIP1/WAF1 in lung alveolar epithelial cell growth arrest induced by glucocorticoids. Endocrinology, 138: 3677-3685, 1997.
55. Kip1 is haplo-insufficient for tumour suppression. Nature (Lond.), 396: 177-180, 1998.
56. 1 and altered expression of cyclin D1 and p27(Kip-1) after forced connexin expression in lung and liver carcinoma cells. J. Cell. Biochem., 79: 347-354, 2000.
57. KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. Cancer Res., 58: 1042-1047, 1998.
58. kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras. Cancer Res., 59: 684-688, 1999.
59. Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines. Jpn. J. Cancer Res., 89: 110-115, 1998.
60. 1 arrest induced by inhibition of epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J. Biol. Chem., 275: 6987-6995, 2000.
61. Tsubari, M., Taipale, J., Tiihonen, E., Keski-Oja, J., and Laiho, M. Hepatocyte growth factor releases mink epithelial cells from transforming growth factor β1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity. Mol. Cell. Biol., 19: 3654-3663, 1999.
62. Pincus, M. R., Brandt-Rauf, P. W., Michl, J., Carty, R. P., and Friedman, F. K. Ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents. Cancer Investig., 18: 39-50, 2000.
63. Malkinson, A. M., Dwyer-Nield, L. D., Rice, P. L., and Dinsdale, D. Mouse lung epithelial cell lines-tools for the study of differentiation and the neoplastic phenotype. Toxicology, 123: 53-100, 1997.
64. Ramakrishna, G., Bialkowska, A., Perella, C., Birely, L., Fornwald, L. W., Diwan, B. A., Shiao, Y.-H., and Anderson, L. M. Ki-ras and the characteristics of mouse lung tumors. Mol. Carcinog., 28: 156-167, 2000.
65. De Rooij, J., and Bos, J. L. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene, 14: 623-625, 1997.
66. Taylor, S. J., and Shalloway D. Cell cycle-dependent activation of Ras. Curr. Biol., 6: 1621-1627, 1996.
67. Ausubel, F., Brent, R., and Kingston, R. E. Short Protocols in Molecular Biology, Ed. 3, p. 10-7. New York: John Wiley and Sons, 1995.