Mal-development of the penis and loss of fertility in male rats treated neonatally with female contraceptive 17α-ethinyl estradiol: A dose-response study and a comparative study with a known estrogenic teratogen diethylstilbestrol

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 331-343

  Mathews, Ensa ^a   Braden, Tim D ^b   Williams, Carol S ^a   Williams, John W ^a   Bolden Tiller, Olga ^a   Goyal, Hari O ^a  

^a TUSKEGEE UNIVERSITY   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

DES; Development; Ethinyl estradiol; Penis; Toxicology

Indexed keywords

DIETHYLSTILBESTROL; ETHINYLESTRADIOL; TERATOGENIC AGENT; TESTOSTERONE;

AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EPIDIDYMIS FAT; FEMALE; MALE; MALE GENITAL TRACT MALFORMATION; MALE INFERTILITY; MICROPENIS; NEWBORN; NONHUMAN; PERINATAL PERIOD; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SPERMATOZOON COUNT; TERATOGENICITY; TESTIS WEIGHT; ANIMAL; BLOOD; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CONGENITAL MALFORMATION; DRUG EFFECT; ORGAN SIZE; PENIS;

ANIMALIA; RATTUS;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; DIETHYLSTILBESTROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHINYL ESTRADIOL; FEMALE; INFERTILITY, MALE; MALE; ORGAN SIZE; PENIS; RATS; TERATOGENS; TESTOSTERONE;

EID: 74949086999     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp207     Document Type: Article

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