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Volumn 81, Issue 3, 2009, Pages 507-516

Estrogen-induced developmental disorders of the rat penis involve both estrogen receptor (ESR)- and androgen receptor (AR)-mediated pathways

Author keywords

Androgen receptor; Erectile dysfunction; Estradiol; Estradiol receptor; Estrogen; Estrogen receptor; Penis; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; DIETHYLSTILBESTROL; ESTROGEN RECEPTOR; FULVESTRANT; TESTOSTERONE;

EID: 69849106578     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.071951     Document Type: Article
Times cited : (19)

References (53)
  • 1
    • 33750860511 scopus 로고    scopus 로고
    • Fertility grounds for inquiry: Environmental effects on human reproduction
    • Barrett JR. Fertility grounds for inquiry: environmental effects on human reproduction. Environ Health Perspect 2006; 114:A644-A649.
    • (2006) Environ Health Perspect , vol.114
    • Barrett, J.R.1
  • 3
    • 0034956043 scopus 로고    scopus 로고
    • From malformations to molecular mechanisms in the male: Three decades of research on endocrine disrupters
    • McLachlan JA, Newbold RR, Burow ME, Li SF. From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters. APMIS 2001; 109:263-272. (Pubitemid 32588599)
    • (2001) APMIS , vol.109 , Issue.4 , pp. 263-272
    • McLachlan, J.A.1    Newbold, R.R.2    Burow, M.E.3    Li, S.F.4
  • 4
    • 0018650202 scopus 로고
    • Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities
    • Gill WB, Schmacher GFB, Bibbo M, Straus FH, Schoenberg HW. Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. J Urol 1979; 122:36-39. (Pubitemid 9248408)
    • (1979) Journal of Urology , vol.122 , Issue.1 , pp. 36-39
    • Gill, W.B.1    Schumacher, G.F.B.2    Bibbo, M.3
  • 5
    • 0037197038 scopus 로고    scopus 로고
    • Hypospadias in sons of women exposed to diethylstilbestrol in utero: A cohort study
    • Klip H, Verloop J, van Gool JD, Koster ME, Burger CW, van Leeuwen FE. Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study. Lancet 2002; 359(9312):1081-1082.
    • (2002) Lancet , vol.359 , Issue.9312 , pp. 1081-1082
    • Klip, H.1    Verloop, J.2    Van Gool, J.D.3    Koster, M.E.4    Burger, C.W.5    Van Leeuwen, F.E.6
  • 6
    • 0033973630 scopus 로고    scopus 로고
    • A maternal vegetarian diet in pregnancy is associated with hypospadias: The ALSPAC Study Team: Avon Longitudinal Study of Pregnancy and Childhood
    • North K, Golding J. A maternal vegetarian diet in pregnancy is associated with hypospadias: the ALSPAC Study Team: Avon Longitudinal Study of Pregnancy and Childhood. BJU Int 2000; 85:107-113.
    • (2000) BJU Int , vol.85 , pp. 107-113
    • North, K.1    Golding, J.2
  • 7
    • 34250213668 scopus 로고    scopus 로고
    • Declines in sex ratio at birth and fetal deaths in Japan, and in U.S. whites but not African Americans
    • DOI 10.1289/ehp.9540
    • Davis DL, Webster P, Stainthorpe H, Chilton J, Jones L, Doi R. Declines in sex ratio at birth and fetal deaths in Japan, and in U.S. whites but not African Americans. Environ Health Perspect 2007; 115:941-946. (Pubitemid 46902251)
    • (2007) Environmental Health Perspectives , vol.115 , Issue.6 , pp. 941-946
    • Davis, D.L.1    Webster, P.2    Stainthorpe, H.3    Chilton, J.4    Jones, L.5    Doi, R.6
  • 8
    • 1542351641 scopus 로고    scopus 로고
    • Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens
    • DOI 10.1016/S0013-9351(03)00085-9, PII S0013935103000859
    • Kim KS, Torres CR Jr, Yucel S, Raimondo K, Cunha GR, Baskin LS. Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environ Res 2004; 94:267-275. (Pubitemid 38328680)
    • (2004) Environmental Research , vol.94 , Issue.3 , pp. 267-275
    • Kim, K.S.1    Torres Jr., C.R.2    Yucel, S.3    Raimondo, K.4    Cunha, G.R.5    Baskin, L.S.6
  • 9
    • 33745246032 scopus 로고    scopus 로고
    • Developmental exposure to estradiol and bisphenol a increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
    • Ho SM, Tang WY, de Belmonte FJ, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 2006; 66:5624-5632.
    • (2006) Cancer Res , vol.66 , pp. 5624-5632
    • Ho, S.M.1    Tang, W.Y.2    De Belmonte, F.J.3    Prins, G.S.4
  • 10
    • 0029923149 scopus 로고    scopus 로고
    • Reduction in penis size and plasma testosterone concentration in juvenile alligators living in a contaminated environment
    • Guillette LJ Jr, Pickford DB, Crain DA, Rooney AA, Percival HF. Reduction in penis size and plasma testosterone concentration in juvenile alligators living in a contaminated environment. Gen Comp Endocrinol 1996; 101:32-42.
    • (1996) Gen Comp Endocrinol , vol.101 , pp. 32-42
    • Guillette Jr., L.J.1    Pickford, D.B.2    Crain, D.A.3    Rooney, A.A.4    Percival, H.F.5
  • 11
    • 27144552271 scopus 로고    scopus 로고
    • Altered neonatal development and endocrine function in Alligator mississippiensis associated with a contaminated environment
    • Milnes MR, Bermudez DS, Bryan TA, Gunderson MP, Guillette LJ. Altered neonatal development and endocrine function in Alligator mississippiensis associated with a contaminated environment. Biol Reprod 2005; 73:1004-1010.
    • (2005) Biol Reprod , vol.73 , pp. 1004-1010
    • Milnes, M.R.1    Bermudez, D.S.2    Bryan, T.A.3    Gunderson, M.P.4    Guillette, L.J.5
  • 12
    • 33847195811 scopus 로고    scopus 로고
    • Reproductive deficits in male freshwater turtle Chrysemys picta from Cape Cod, Massachusetts
    • Kitama N, Won SJ, Callard IP. Reproductive deficits in male freshwater turtle Chrysemys picta from Cape Cod, Massachusetts. Biol Reprod 2007; 76:346-352.
    • (2007) Biol Reprod , vol.76 , pp. 346-352
    • Kitama, N.1    Won, S.J.2    Callard, I.P.3
  • 13
    • 1542513445 scopus 로고    scopus 로고
    • Exposure of neonatal male rats to estrogen induces abnormal morphology of the penis and loss of fertility
    • DOI 10.1016/j.reprotox.2003.12.001, PII S0890623803001679
    • Goyal HO, Braden TD, Williams CS, Dalvi P, Williams JW, Srivastava KK. Exposure of neonatal male rats to estrogen induces abnormal morphology of the penis and loss of fertility. Reprod Toxicol 2004; 18: 265-274. (Pubitemid 38333049)
    • (2004) Reproductive Toxicology , vol.18 , Issue.2 , pp. 265-274
    • Goyal, H.O.1    Braden, T.D.2    Williams, C.S.3    Dalvi, P.4    Williams, J.W.5    Srivastava, K.K.6
  • 14
    • 10844264689 scopus 로고    scopus 로고
    • Permanent induction of morphological abnormalities in the penis and penile skeletal muscles in adult rats treated neonatally with diethylstilbestrol or estradiol valerate: A dose-response study
    • Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour MM, Williams JW. Permanent induction of morphological abnormalities in the penis and penile skeletal muscles in adult rats treated neonatally with diethylstilbestrol or estradiol valerate: a dose-response study. J Androl 2005; 26:32-43. (Pubitemid 39665273)
    • (2005) Journal of Andrology , vol.26 , Issue.1 , pp. 32-43
    • Goyal, H.O.1    Braden, T.D.2    Williams, C.S.3    Dalvi, P.4    Mansour, M.M.5    Williams, J.W.6
  • 15
    • 24044440787 scopus 로고    scopus 로고
    • Estrogen-induced abnormal accumulation of fat cells in the rat penis and associated loss of fertility depends upon estrogen exposure during critical period of penile development
    • DOI 10.1093/toxsci/kfi233
    • Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour M, Williams JW. Estrogen-induced abnormal accumulation of fat cells in the rat penis and associated loss of fertility depends upon estrogen exposure during critical period of penile development. Toxicol Sci 2005; 87:242-254. (Pubitemid 41222677)
    • (2005) Toxicological Sciences , vol.87 , Issue.1 , pp. 242-254
    • Goyal, H.O.1    Braden, T.D.2    Williams, C.S.3    Dalvi, P.4    Mansour, M.5    Williams, J.W.6
  • 16
    • 11144355160 scopus 로고    scopus 로고
    • Abnormal morphology of the penis in male rats exposed neonatally to diethylstilbestrol is associated with altered profile of estrogen receptor-a protein, but not of androgen receptor protein: A developmental and immunocytochemical study
    • Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour MM, Mansour M, Williams JW, Bartol FF, Wiley AA, Birch L, Prins GS. Abnormal morphology of the penis in male rats exposed neonatally to diethylstilbestrol is associated with altered profile of estrogen receptor-a protein, but not of androgen receptor protein: a developmental and immunocytochemical study. Biol Reprod 2004; 70:284-297.
    • (2004) Biol Reprod , vol.70 , pp. 284-297
    • Goyal, H.O.1    Braden, T.D.2    Williams, C.S.3    Dalvi, P.4    Mansour, M.M.5    Mansour, M.6    Williams, J.W.7    Bartol, F.F.8    Wiley, A.A.9    Birch, L.10    Prins, G.S.11
  • 18
    • 0021326514 scopus 로고
    • Differential effects of maternal stress on circulating levels of corticosterone, progesterone, and testosterone in male and female rat fetuses and their mothers
    • Ward IL, Weisz J. Differential effects of maternal stress on circulating levels of corticosterone, progesterone, and testosterone in male and female rat fetuses and their mothers. Endocrinology 1984; 114:1635-1644. (Pubitemid 14140314)
    • (1984) Endocrinology , vol.114 , Issue.5 , pp. 1635-1644
    • Ward, I.L.1    Weisz, J.2
  • 19
    • 0031973722 scopus 로고    scopus 로고
    • Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis
    • DOI 10.1095/biolreprod58.1.116
    • El-Gehani F, Zhang FP, Pakarinen P, Rannikko A, Huhtaniemi I. Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis. Biol Reprod 1998; 58:116-123. (Pubitemid 28023740)
    • (1998) Biology of Reproduction , vol.58 , Issue.1 , pp. 116-123
    • El-Gehani, F.1    Zhang, F.-P.2    Pakarinen, P.3    Rannikko, A.4    Huhtaniemi, I.5
  • 20
    • 0036892967 scopus 로고    scopus 로고
    • Evidence for a potential role of estrogen in the penis: Detection of estrogen receptor-α and -β messenger ribonucleic acid and protein
    • DOI 10.1210/en.2002-220628
    • Jesmin S, Mowa CN, Matsuda N, Salah-Eldin AE, Togashi H, Sakuma I, Hattori Y, Kitabatake A. Evidence for a potential role of estrogen in the penis: detection of estrogen receptor-α and -β messenger ribonucleic acid and protein. Endocrinology 2002; 143:4764-4774. (Pubitemid 35402077)
    • (2002) Endocrinology , vol.143 , Issue.12 , pp. 4764-4774
    • Jesmin, S.1    Mowa, C.N.2    Matsuda, N.3    Salah-Eldin, A.-E.4    Togashi, H.5    Sakuma, I.6    Hattori, Y.7    Kitabatake, A.8
  • 21
    • 1642502447 scopus 로고    scopus 로고
    • Neonatal Coadministration of Testosterone with Diethylstilbestrol Prevents Diethylstilbestrol Induction of Most Reproductive Tract Abnormalities in Male Rats
    • Rivas A, McKinnell C, Fisher JS, Atanassova N, Williams K, Sharpe RM. Neonatal coadministration of testosterone with diethylstilbestrol prevents induction of most reproductive tract abnormalities in male rats. J Androl 2003; 24:557-567. (Pubitemid 38129057)
    • (2003) Journal of Andrology , vol.24 , Issue.4 , pp. 557-567
    • Rivas, A.1    McKinnell, C.2    Fisher, J.S.3    Atanassova, N.4    Williams, K.5    Sharpe, R.M.6
  • 22
    • 0035113688 scopus 로고    scopus 로고
    • Diethylstilbestrol-treated adult rats with altered epididymal sperm numbers and sperm motility parameters, but without alterations in sperm production and sperm morphology
    • Goyal HO, Braden TD, Mansour M, Williams CS, Kamaleldin A, Srivastava KK. Diethylstilbestrol-treated adult rats with altered epididymal sperm numbers and sperm motility parameters, but without alterations in sperm production and sperm morphology. Biol Reprod 2001; 64:927-934. (Pubitemid 32174066)
    • (2001) Biology of Reproduction , vol.64 , Issue.3 , pp. 927-934
    • Goyal, H.O.1    Braden, T.D.2    Mansour, M.3    Williams, C.S.4    Kamaleldin, A.5    Srivastava, K.K.6
  • 25
    • 10044259640 scopus 로고    scopus 로고
    • Role of estrogens in adipocyte development and function
    • Cooke PS, Naaz A. Role of estrogen in adipocyte development and function. Exp Biol Med 2004; 229:1127-1135. (Pubitemid 39602255)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.11 , pp. 1127-1135
    • Cooke, P.S.1    Naaz, A.2
  • 26
    • 0034471451 scopus 로고    scopus 로고
    • Intrauterine exposure to diethylstilbestrol: Long-term effects in humans
    • Swan SH. Intrauterine exposure to diethylstilbestrol: long-term effects in humans. APMIS 2000; 108:793-804. (Pubitemid 32173609)
    • (2000) APMIS , vol.108 , Issue.12 , pp. 793-804
    • Swan, S.H.1
  • 27
    • 0019138184 scopus 로고
    • Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis
    • DOI 10.1016/0022-4731(80)90064-3
    • Rajfer J, Namkung PC, Petra PH. Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis. J Steroid Biochem 1980; 13:1489-1492. (Pubitemid 11176378)
    • (1980) Journal of Steroid Biochemistry , vol.13 , Issue.12 , pp. 1489-1492
    • Rajfer, J.1    Namkung, P.C.2    Petra, P.H.3
  • 28
    • 0025052060 scopus 로고
    • Androgen receptor of rat penis is down regulated by androgen
    • Takane KK, George FW, Wilson JD. Androgen receptor of rat penis is down regulated by androgen. Am J Physiol 1990; 21:E46-E50.
    • (1990) Am J Physiol , vol.21
    • Takane, K.K.1    George, F.W.2    Wilson, J.D.3
  • 29
    • 0014555672 scopus 로고
    • Effects of perinatal androgen treatment on responses of male rats to gonadal hormones in adulthood
    • Beach FA, Noble RG, Orndoff RK. Effects of perinatal androgen treatment on responses of male rats to gonadal hormones in adulthood. J Comparat Physiol Psychol 1969; 68:490-497.
    • (1969) J Comparat Physiol Psychol , vol.68 , pp. 490-497
    • Beach, F.A.1    Noble, R.G.2    Orndoff, R.K.3
  • 31
    • 20544437132 scopus 로고    scopus 로고
    • Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    • Foster PMD, Harris MW. Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages. Toxicol Sci 2005; 85:1024-1032.
    • (2005) Toxicol Sci , vol.85 , pp. 1024-1032
    • Foster, P.M.D.1    Harris, M.W.2
  • 32
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • DOI 10.1093/toxsci/58.2.350
    • Gray LE Jr, Ostby J, Furr J, Wolf CJ, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not dEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000; 58:350-365. (Pubitemid 32042433)
    • (2000) Toxicological Sciences , vol.58 , Issue.2 , pp. 350-365
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.R.5    Parks, L.6
  • 33
    • 0025044248 scopus 로고
    • External genitalia of the rat: Normal development and the histogenesis of 5α-reductase inhibitor-induced abnormalities
    • Anderson CA, Clark RL. External genitalia of the rat: normal development and the histogenesis of 5α-reductase inhibitor-induced abnormalities. Teratology 1990; 42:483-496.
    • (1990) Teratology , vol.42 , pp. 483-496
    • Anderson, C.A.1    Clark, R.L.2
  • 34
    • 0022922794 scopus 로고
    • Development of the os penis in genital tubercles cultured beneath the renal capsule of adult rats
    • Murakami R. Development of the os penis in genital tubercles cultured beneath the renal capsule of adult rats. J Anat 1986; 149:11-20. (Pubitemid 17006055)
    • (1986) Journal of Anatomy , vol.VOL. 149 , pp. 11-20
    • Murakami, R.1
  • 35
    • 0023394182 scopus 로고
    • A histological study of the development of the penis of wildtype and androgen-insensitive mice
    • Murakami R. A histological study of the development of the penis of wildtype and androgen-insensitive mice. J Anat 1987; 153:223-231.
    • (1987) J Anat , vol.153 , pp. 223-231
    • Murakami, R.1
  • 36
    • 0017236710 scopus 로고
    • The effect of neonatal treatment of male mice with antiandrogens and of females with androgens on the development of the os penis and os clitoridis
    • Glucksmann A, Ooka-Souda S, Miura-Yasugi E, Mizuno T. The effect of neonatal treatment of male mice with antiandrogens and of females with androgens on the development of the os penis and os clitoridis. J Anat 1976; 121:363-370.
    • (1976) J Anat , vol.121 , pp. 363-370
    • Glucksmann, A.1    Ooka-Souda, S.2    Miura-Yasugi, E.3    Mizuno, T.4
  • 37
    • 14344264330 scopus 로고    scopus 로고
    • Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: A potential mechanism for veno-occlusive dysfunction in androgen deficiency
    • Traish AM, Toselli P, Jeong SJ, Kim NN. Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiency. J Androl 2005; 26:242-248. (Pubitemid 40293710)
    • (2005) Journal of Andrology , vol.26 , Issue.2 , pp. 242-248
    • Traish, A.M.1    Toselli, P.2    Jeong, S.-J.3    Kim, N.N.4
  • 38
    • 0001872893 scopus 로고
    • Sex determination and differentiation
    • Knobil E, Neil J (eds.) New York: Raven Press
    • George FW, Wilson JD. Sex determination and differentiation. In: Knobil E, Neil J (eds.) The Physiology of Reproduction, 2nd ed. New York: Raven Press; 1994:3-28.
    • (1994) The Physiology of Reproduction, 2nd Ed. , pp. 3-28
    • George, F.W.1    Wilson, J.D.2
  • 39
    • 2342517388 scopus 로고    scopus 로고
    • Molecular and genetic regulation of testis descent and external genitalia development
    • DOI 10.1016/j.ydbio.2004.02.018, PII S001216060400137X
    • Klonisch T, Fowler PA, Hombach-Klonisch S. Molecular and genetic regulation of testis descent and external genitalia development. Dev Biol 2004; 270:1-18. (Pubitemid 38596925)
    • (2004) Developmental Biology , vol.270 , Issue.1 , pp. 1-18
    • Klonisch, T.1    Fowler, P.A.2    Hombach-Klonisch, S.3
  • 40
    • 0016804566 scopus 로고
    • Changes with age in levels of serum gonadotropins, prolactin, and gonadal steroids in prepubertal male and female rats
    • Dohler KD, Wuttke W. Changes with age in levels of serum gonadotropins, prolactin, and gonadal steroids in prepubertal male and female rats. Endocrinology 1975; 97:898-907.
    • (1975) Endocrinology , vol.97 , pp. 898-907
    • Dohler, K.D.1    Wuttke, W.2
  • 41
    • 0031790274 scopus 로고    scopus 로고
    • Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells
    • Ren-Shan GE, Hardy MP. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998; 139:3787-3795.
    • (1998) Endocrinology , vol.139 , pp. 3787-3795
    • Ren-Shan, G.E.1    Hardy, M.P.2
  • 42
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 7:1147-1156.
    • (1994) Cell , vol.7 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 43
    • 53149137060 scopus 로고    scopus 로고
    • Activation of penile pro-adipogenic peroxisome proliferator-activated receptor γ (PPARγ) with an estrogen: Interaction with estrogen receptor alpha (ERα) during postnatal development
    • DOI 10.1155/2008/651419
    • Mansour M, Goyal HO, Braden T, Dennis J, Schwartz D, Judd R, Bartol F, Coleman E, Morrison E. Activation of penile pro-adipogenic peroxisome proliferator-activated receptor γ (PPARγ) with an estrogen: interaction with estrogen receptor alpha (ERα) during postnatal development. PPPAR Res 2008; 2008: 651419. DOI 10.1155/2008/651419.
    • (2008) PPPAR Res , vol.2008 , pp. 651419
    • Mansour, M.1    Goyal, H.O.2    Braden, T.3    Dennis, J.4    Schwartz, D.5    Judd, R.6    Bartol, F.7    Coleman, E.8    Morrison, E.9
  • 45
    • 0033303787 scopus 로고    scopus 로고
    • Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficacy of spermatogenesis in adulthood
    • Atanassova N, McKinnell C, Turner KJ, Walker M, Fisher JS, Morley M, Millar MR, Groome NP, Sharpe RM. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficacy of spermatogenesis in adulthood. Endocrinology 1999; 140:5364-5373.
    • (1999) Endocrinology , vol.140 , pp. 5364-5373
    • Atanassova, N.1    McKinnell, C.2    Turner, K.J.3    Walker, M.4    Fisher, J.S.5    Morley, M.6    Millar, M.R.7    Groome, N.P.8    Sharpe, R.M.9
  • 46
    • 0034761213 scopus 로고    scopus 로고
    • Neonatal lowand high-dose exposure to estradiol benzoate in the male rat, II: Effects on male puberty and the reproductive tract
    • Putz O, Scwartz CB, LeBlanc GA, Cooper RL, Prins GS. Neonatal lowand high-dose exposure to estradiol benzoate in the male rat, II: effects on male puberty and the reproductive tract. Biol Reprod 2001; 65:1506-1517.
    • (2001) Biol Reprod , vol.65 , pp. 1506-1517
    • Putz, O.1    Scwartz, C.B.2    LeBlanc, G.A.3    Cooper, R.L.4    Prins, G.S.5
  • 47
    • 0038513527 scopus 로고    scopus 로고
    • Neonatal estrogen exposure of male rats alters reproductive functions at adulthood
    • DOI 10.1095/biolreprod.102.010637
    • Goyal HO, Robateau A, Braden TD, Williams CS, Srivastava KK, Ali K. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol Reprod 2003; 68:2081-2091. (Pubitemid 36686999)
    • (2003) Biology of Reproduction , vol.68 , Issue.6 , pp. 2081-2091
    • Goyal, H.O.1    Robateau, A.2    Braden, T.D.3    Williams, C.S.4    Srivastava, K.K.5    Ali, K.6
  • 48
    • 0030975888 scopus 로고    scopus 로고
    • Immunolocalisation of oestrogen receptor-α within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood
    • Fisher JS, Millar MR, Majdic G, Saunders PT, Fraser HM, Sharpe RM. Immunolocalization of oestrogen receptor-α (ERα) within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J Endocrinol 1997; 153:485-495. (Pubitemid 27261259)
    • (1997) Journal of Endocrinology , vol.153 , Issue.3 , pp. 485-495
    • Fisher, J.S.1    Millar, M.R.2    Majdic, G.3    Saunders, P.T.K.4    Fraser, H.M.5    Sharpe, R.M.6
  • 49
    • 0035002848 scopus 로고    scopus 로고
    • Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: Evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man
    • DOI 10.1093/humupd/7.3.236
    • Williams K, McKinnell C, Saunders PTK, Walker M, Fisher JS, Turner KJ, Atanassova N, Sharpe RM. Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man. Hum Reprod Update 2001; 7:236-247. (Pubitemid 32440286)
    • (2001) Human Reproduction Update , vol.7 , Issue.3 , pp. 236-247
    • Williams, K.1    McKinnell, C.2    Saunders, P.T.K.3    Walker, M.4    Fisher, J.S.5    Turner, K.J.6    Atanassova, N.7    Sharpe, R.M.8
  • 50
    • 0028103854 scopus 로고
    • Immunohistochemical localization of androgen receptor in the rat testis: Evidence for stagedependent expression and regulation by androgens
    • Bremner WJ, Millar MR, Sharpe RM, Saunders PTK. Immunohistochemical localization of androgen receptor in the rat testis: evidence for stagedependent expression and regulation by androgens. Endocrinology 1994; 135:1227-1234.
    • (1994) Endocrinology , vol.135 , pp. 1227-1234
    • Bremner, W.J.1    Millar, M.R.2    Sharpe, R.M.3    Saunders, P.T.K.4
  • 51
    • 0028214881 scopus 로고
    • Androgen receptor distribution in rat testis: New implications for androgen regulation of spermatogenesis
    • DOI 10.1210/en.134.5.2307
    • Vornberger W, Prins G, Musto NA, Suarez-Quian CA. Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology 1994; 134:2307-2316. (Pubitemid 24142977)
    • (1994) Endocrinology , vol.134 , Issue.5 , pp. 2307-2316
    • Vornberger, W.1    Prins, G.2    Musto, N.A.3    Suarez-Quian, C.A.4
  • 52
    • 0030213873 scopus 로고    scopus 로고
    • The effects of androgen administration on phallic androgen receptor expression
    • Levy JB, Seay TM, Tindall DJ, Husmann DA. The effects of androgen administration on phallic androgen receptor expression. J Urol 1996; 156: 775-779. (Pubitemid 126444924)
    • (1996) Journal of Urology , vol.156 , Issue.2 SUPPL. 1 , pp. 775-779
    • Levy, J.B.1    Seay, T.M.2    Tindall, D.J.3    Husmann, D.A.4
  • 53
    • 0034887721 scopus 로고    scopus 로고
    • Infertility and testicular atrophy in the antiestrogen-treated adult male rat
    • Oliveira CA, Carnes K, Franca LR, Hess RA. Infertility and testicular atrophy in the antiestrogen-treated adult male rat. Biol Reprod 2001; 65: 913-920. (Pubitemid 32777380)
    • (2001) Biology of Reproduction , vol.65 , Issue.3 , pp. 913-920
    • Oliveira, C.A.1    Carnes, K.2    Franca, L.R.3    Hess, R.A.4


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