Hypospadias: A transgenerational effect of diethylstilbestrol?

Human Reproduction

Volumn 21, Issue 3, 2006, Pages 666-669

  Brouwers, M M ^a   Feitz, W F J ^a   Roelofs, L A J ^a   Kiemeney, L A L M ^a   de Gier, R P E ^a   Roeleveld, N ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diethylstilbestrol; Hypospadias; Offspring; Transgenerational effects

Indexed keywords

DIETHYLSTILBESTROL;

ARTICLE; CASE STUDY; CLINICAL ASSESSMENT; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA BASE; ENVIRONMENTAL EXPOSURE; FEMALE; HEALTH HAZARD; HOSPITAL INFORMATION SYSTEM; HUMAN; HYPOSPADIAS; INFORMATION RETRIEVAL; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PARENT; PATIENT REFERRAL; PRENATAL EXPOSURE; QUESTIONNAIRE; RISK ASSESSMENT; SCHOOL CHILD;

EID: 33644865309     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei398     Document Type: Article

References (20)

1. Blatt J, Van Le L, Weiner T and Sailer S (2003) Ovarian carcinoma in an adolescent with transgenerational exposure to diethylstilbestrol. J Pediatr Hematol Oncol 25,635-636.
2. Fisch H, Golden RJ, Libersen GL, Hyun GS, Madsen P, New MI and Hensle TW (2001) Maternal age as a risk factor for hypospadias. J Urol 165,934-936.
3. Fredell L, Iselius L, Collins A, Hansson E, Holmner S, Lundquist L, Lackgren G, Pedersen J, Stenberg A, Westbacke G et al (2002a) Complex segregation analysis of hypospadias. Hum Genet 111,231-234.
4. Fredell L, Kockum I, Hansson E, Holmner S, Lundquist L, Lackgren G, Pedersen J, Stenberg A, Westbacke G and Nordenskjold A (2002b) Heredity of hypospadias and the significance of low birth weight. J Urol 167,1423-1427.
5. Giusti RM, Iwamoto K and Hatch EE (1995) Diethylstilbestrol revisited: A review of the long-term health effects. Ann Intern Med 122,778-788.
6. Hernandez-Diaz S (2002) Iatrogenic legacy from diethylstilbestrol exposure. Lancet 359,1081-1082.
7. Hussain N, Chaghtai A, Herndon CD, Herson VC, Rosenkrantz TS and McKenna PH (2002) Hypospadias and early gestation growth restriction in infants. Pediatrics 109,473-478.
8. Klip H, Verloop J, van Gool JD, Koster ME, Burger CW and van Leeuwen FE (2002) Hypospadias in sons of women exposed to diethylstilbestrol in utero: A cohort study. Lancet 359,1102-1107.
9. Manson JM and Carr MC (2003) Molecular epidemiology of hypospadias: review of genetic and environmental risk factors. Birth Defects Res A, Clini Mol Teratol 67,825-836.
10. Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman I and McLachlan JA (1998) Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19,1655-1663.
11. Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J and McLachlan JA (2000) Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21,1355-1363.
12. North K and Golding J (2000) A maternal vegetarian diet in pregnancy is associated with hypospadias The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Br J Urol Int 85,107-113.
13. Palmer JR, Wise LA, Robboy SJ, Titus-Emstoff L, Moller KL, Herbst AL, Troisi R and Hoover RN (2005) Hypospadias in sons of women exposed to diethylstilbestrol in utero. Epidemiology 16,583-586.
14. Pierik FH, Burdorf A, Nijman JM, de Muinck Keizer-Schrama SM, Juttmann RE and Weber RF (2002) A high hypospadias rate in The Netherlands. Hum Reprod 17,1112-1115.
15. Pierik FH, Burdorf A, Deddens JA, Juttmann RE and Weber RF (2004) Maternal and paternal risk factors for cryptorchidism and hypospadias: A case-control study in newborn boys. Environ Health Perspect 112, 1570-1576.
16. Pons JC, Papiernik E, Billon A, Hessabi M and Duyne M (2005) Hypospadias in sons of women exposed tot diethylstilbestrol in utero. Prenat Diagn 25,418-419.
17. Silver RI, Rodriguez R, Chang TS and Gearhart JP (1999) In vitro fertilization is associated with an increased risk of hypospadias. J Urol 161,1954-1957.
18. Sorber M, Feitz WF and de Vries JD (1997) Short- and mid-term outcome of different types of one-stage hypospadias corrections. Eur Urol 32,475-479.
19. Weidner IS, Moller H, Jensen TK and Skakkebaek NE (1999) Risk factors for cryptorchidism and hypospadias. J Urol 161,1606-1609.
20. Wennerholm UB, Bergh C, Hamberger L, Lundin K, Nilsson L, Wikland M and Kallen B (2000) Incidence of congenital malformations in children born after ICSI. Hum Reprod 15,944-948.