Mixtures of hemoglobin-based oxygen carriers and perfluorocarbons exhibit a synergistic effect in oxygenating hepatic hollow fiber bioreactors

Biotechnology and Bioengineering

Volumn 105, Issue 3, 2010, Pages 534-542

  Chen, Guo ^a   Palmer, Andre F ^a  

^a Ohio State University   (United States)

Author keywords

Bioartificial liver assist device; Hemoglobin based oxygen carrier; Hollow fiber bioreactor; Mathematical model; Oxygen transport; Perfluorocarbon

Indexed keywords

BIOARTIFICIAL LIVER ASSIST DEVICES; HEMOGLOBIN-BASED OXYGEN CARRIERS; HOLLOW FIBER BIOREACTOR; OXYGEN TRANSPORT; PERFLUOROCARBONS;

BIOCHEMICAL OXYGEN DEMAND; BIOCONVERSION; BIOREACTORS; CELL CULTURE; CIRCULATING MEDIA; COMPUTER SIMULATION; DIFFERENTIAL EQUATIONS; DISSOLUTION; FIBER OPTIC SENSORS; FIBERS; HEMOGLOBIN; INDUCTIVELY COUPLED PLASMA; LIVER; MATHEMATICAL MODELS; MIXTURES; OXYGEN; OXYGENATION; POLYVINYL ALCOHOLS;

TRANSPORT PROPERTIES;

FLUOROCARBON; HEMOGLOBIN; OXYGEN;

ARTICLE; BIOARTIFICIAL LIVER; FLUID TRANSPORT; HOLLOW FIBER REACTOR; LIVER CELL; LIVER SINUSOID; MATHEMATICAL MODEL; OXYGEN TRANSPORT;

BIOREACTORS; FLUOROCARBONS; HEMOGLOBINS; LIVER, ARTIFICIAL; OXYGEN;

EID: 74849138341     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22571     Document Type: Article

References (38)

1. Allen JW, Bhatia SN. 2003. Formation of steady-state oxygen gradients in vitro: Application to liver zonation. Biotechnol Bioeng 82(3):253-262.
2. Barbee KA. 2005. Mechanical cell injury. Ann N Y Acad Sci 1066:67-84.
3. Bear J. 1972. Dynamics of fluids in porous media. New York: American Elsevier Pub. Co.
4. Bird RB, Stewart WE, Lightfoot EN. 2002. Transport phenomena. New York: John Wiley & Sons, Inc.
5. Bjorkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM. 2005. A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated poly(ethylene glycol). Haematologica 90(4):505-515.
6. Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. 2005. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem 77(11): 3466-3478.
7. Centis V, Vermette P. 2009. Enhancing oxygen solubility using hemoglobinand perfluorocarbon-based carriers. Front Biosci 14:665-688.
8. Chan C, Berthiaume F, Nath BD, Tilles AW, Toner M, Yarmush ML. 2004. Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies. Liver Transpl 10(11):1331-1342.
9. Chen G, Palmer AF. 2009a. Hemoglobin-based oxygen carrier and convection enhanced oxygen transport in a hollow fiber bioreactor. Biotechnol Bioeng 102(6):1603-1612.
10. Chen G, Palmer AF. 2009b. Perfluorocarbon facilitated O(2) transport in a hepatic hollow fiber bioreactor. Biotechnol Prog 25(5):1317-1321.
11. Cohn CS, Cushing MM. 2009. Oxygen therapeutics: Perfluorocarbons and blood substitute safety. Crit Care Clin 25(2):399-414.
12. D'Angio CT, Finkelstein JN. 2000. Oxygen regulation of gene expression: A study in opposites. Mol Genet Metab 71:371-380.
13. Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML. 1994. A device to measure the oxygen uptake rate of attached cells: Importance in bioartificial organ design. Cell Transpl 3(6):515-527.
14. 2 carriers. Biophys Chem 143(1-2):1-17.
15. Hay PD, Veitch AR, Smith MD, Cousins RB, Gaylor JD. 2000. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Organs 24(4):278-288.
16. Jungermann K, Kietzmann T. 1996. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr 16:179-203.
17. Kietzmann T, Dimova EY, Flugel D, Scharf JG. 2006. Oxygen: Modulator of physiological and pathophysiological processes in the liver. Z Gastroenterol 44(1):67-76.
18. Mareels G, Poyck PP, Eloot S, Chamuleau RA, Verdonck PR. 2006. Threedimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver. Ann Biomed Eng 34(11):1729-1744.
19. Middleman S. 1998. An introduction to mass and heat transfer: Principles of analysis and design. John Wiley & Sons, Inc.
20. Millis JM, Losanoff JE. 2005. Technology insight: Liver support systems. Nat Clin Pract Gastroenterol Hepatol 2(9):398-405.
21. Nield DA, Bejan A. 2006. Convection in porous media. New York: Springer. 15 p.
22. Patel S, Mehra A. 1998a. Modeling of oxygen transport in blood-perfluorocarbon emulsion mixtures. Part 1: Oxygen uptake in tubular vessels. ASAIO J 44:144-156.
23. Patel S, Mehra A. 1998b. Modeling of oxygen transport in blood-perfluorocarbon emulsion mixtures. Part 2: Tissue oxygenation. ASAIO J 44:157-165.
24. Piret JM, Cooney CL. 1991. Model of oxygen-transport limitations in hollow fiber bioreactors. Biotechnol Bioeng 37(1):80-92.
25. Radisic M, Deen W, Langer R, Vunjak-Novakovic G. 2005. Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. Am J Physiol Heart Circ Physiol 288:H1278-H1289.
26. Riess JG. 2001. Oxygen carriers ('blood substitutes')-Raison d'etre, chemistry, and some physiology. Chem Rev 101:2797-2919.
27. Riess JG. 2006. Perfluorocarbon-based oxygen delivery. Artif Cells Blood Substit Immobil Biotechnol 34:567-580.
28. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. 2009. Review of hemoglobin-vesicles as artificial oxygen carriers. Artif Organs 33(2): 139-145.
29. Sander R. 1999. Compilation of Henry's law constants for inorganic and organic species of potential importance in environmental chemistry. http://www.mpch-mainz.mpg.de/~sander/res/henry.html
30. Smith MD, Smirthwaite AD, Cairns DE, Cousins RB, Gaylor JD. 1996. Techniques for measurement of oxygen consumption rates of hepatocytes during attachment and post-attachment. Int J Artif Organs 19(1):36-44.
31. Sullivan JP, Palmer AF. 2006. Targeted oxygen delivery within hepatic hollow fiber bioreactors via supplementation of hemoglobin-based oxygen carriers. Biotechnol Prog 22:1374-1387.
32. Sullivan JP, Gordon JE, Palmer AF. 2006. Simulation of oxygen carrier mediated oxygen transport to C3A hepatoma cells housed within a hollow fiber bioreactor. Biotechnol Bioeng 93(2):306-317.
33. Sullivan JP, Gordon JE, Bou-Akl T, Matthew HWT, Palmer AF. 2007. Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers. Artif Cells Blood Substit Immobil Biotechnol 35:585-606.
34. Sullivan JP, Harris DR, Palmer AF. 2008. Convection and hemoglobinbased oxygen carrier enhanced oxygen transport in a hepatic hollow fiber bioreactor. Artif Cells Blood Substit Immobil Biotechnol 36(4): 386-402.
35. 2 therapeutics. Am J Physiol Heart Circ Physiol 285(4):H1411-1419.
36. van de Kerkhove MP, Hoekstra R, Chamuleau RA, van Gulik TM. 2004. Clinical application of bioartificial liver support systems. Ann Surg 240(2):216-230.
37. 2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin. Biochem J 382:183-189.
38. Vandegriff KD, Malavalli A, Wooldridge J, Lohman J, Winslow RM. 2003. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion 43:509-516.