The dihydropyridine analogue cerebrocrast blocks both T-type and L-type calcium currents

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 11, 2009, Pages 923-932

  Drigeľová, Mária ^a   Tarabová, Bohumila ^b   Duburs, Gunars ^c   Lacinová, Ľubica ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

^b Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

Calcium antagonist; Cerebrocrast; Dihydropyridine; Isradipine; L type calcium channel; Nimodipine; State dependent inhibition; T type calcium channel

Indexed keywords

AMLODIPINE; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CEREBROCRAST; ISRADIPINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL 1.2B; VOLTAGE GATED CALCIUM CHANNEL 3.1;

ACTION POTENTIAL; ARTICLE; CALCIUM CURRENT; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; KINETICS; PATCH CLAMP; PRIORITY JOURNAL;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; CELL LINE; DIHYDROPYRIDINES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RECOMBINANT PROTEINS;

EID: 74849102076     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-086     Document Type: Article

References (25)

1. Briede, J., and Duburs, G. 2007. Protective effect of cerebrocrast on rat brain ischaemia induced by occlusion of both common carotid arteries. Cell Biochem. Funct. 25(2): 203-210. doi:10.1002/cbf.1318. PMID:16444767.
2. Briede, J., Heidemanis, K., Dabina, I., and Duburs, G. 2002. Effect of cerebrocrast on the function of human platelets and release of the arachidonic acid from plasma membrane. Cell Biochem. Funct. 20(2): 177-181. doi:10.1002/cbf.944. PMID:11979514.
3. Briede, J., Stivrina, M., Stoldere, D., Bisenieks, E., Uldrikis, J., Poikāns, J., et al. 2004. Effect of new and known 1,4-dihydropyridine derivatives on blood glucose levels in normal and streptozotocin-induced diabetic rats. Cell Biochem. Funct. 22(4): 219-224. doi:10.1002/cbf.1091. PMID:15248181.
4. Briede, J., Stivrina, M., Stoldere, D., Vigante, B., and Duburs, G. 2008a. Effect of cerebrocrast on body and organ weights, food and water intake, and urine output of normal rats. Cell Biochem. Funct. 26(8): 908-915. doi:10.1002/cbf.1525. PMID:19039818.
5. Briede, J., Stivrina, M., Vigante, B., Stoldere, D., and Duburs, G. 2008b. Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in the isolated, perfused normal rat heart. Cell Biochem. Funct. 26(2): 238-245. doi:10.1002/cbf.1442. PMID:17990288.
6. Dubur, G.J., Veveris, M.M., Weinheimer, G., Bisenieks, E.A., Makarova, N.R., Kimenis, A.A., et al. 1989. Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydro- pyridine-3,5-di- carboxylic acid. Arzneimittelforschung, 39(10): 1185-1189. PMID:2532883.
7. 2+) channel subtypes expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 291(2): 464-473. PMID:10525060.
8. Germane, S., Bleidelis, E., Rakauskaite, I., and Klusa, V. 1991. Neuropharmacological study of IOS-1,1212, a novel dihydropyridine derivative. Proc. Latv. Acad. Sci. 45(6): 112-124.
9. 2+ channels by two different mechanisms. J. Physiol. 521(Pt 1): 31-42. doi:10.1111/j.1469-7793.1999.00031.x. PMID:10562332.
10. Klimaviciusa, L., Klusa, V., Duburs, G., Kaasik, A., Kalda, A., and Zharkovsky, A. 2007. Distinct effects of atypical 1,4-dihydropyridines on 1-methyl-4-phenylpyridinium-induced toxicity. Cell Biochem. Funct. 25(1): 15-21. doi:10.1002/cbf.1340. PMID:16927412.
11. Klugbauer, N., Marais, E., Lacinova, L., and Hofmann, F. 1999. A T-type calcium chennel cloned from mouse brain. Pflugers Arch. 437(5):710-715.
12. Klusa, V. 1995. Cerebrocrast. Drags Future, 20: 135-138.
13. Klusa, V., Semenova, T.D., Medvinskaya, N.I., and Fast, A.E. 1995. A novel and study on cerebrocrast (IOS-1212) normalizes disturbances of learning, attention, emotional behaviour and brain biogenic amine levels in prenatally hypoxized rats. Proc. Latv. Acad. Sci. 49(7): 156-161.
14. Kryzhanovskii, G.N., Karpova, M.N., Abrosimov, I.Iu., Pankov, O.Iu., and Lakinina, M.V. 1993. [Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice]. Biull. Eksp. Biol. Med. 115(3): 231-233. PMID:8054599.
15. Lacinová, L. 2005. Voltage-dependent calcium channels. Gen. Physiol. Biophys. 24(Suppl 1): 1-78. PMID:16096350.
16. Lacinová, L., and Hofmann, F. 1998. Isradipine interacts with the open state of the L-type calcium channel at high concentrations. Receptors Channels, 6(3): 153-164. PMID:10100324.
17. 1G subunit by divalent cations and organic blockers. Neuropharmacology, 39(7): 1254-1266. doi:10.1016/S0028-3908(99)00202-6. PMID:10760367.
18. 1C L-type calcium channel. Pflugers Arch. 440(1): 50-60. doi:10.1007/S004249900244. PMID:10863997.
19. McDonald, T.F., Pelzer, S., Trautwein, W., and Pelzer, D.J. 1994. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74(2): 365-507. PMID:8171118.
20. 2+ channel cloned from human heart. Naunyn Schmiedebergs Arch. Pharmacol. 361(6): 590-599. doi:10.1007/s002100000238. PMID:10882033.
21. 2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J. Pharmacol. Exp. Ther. 328(2): 621-627. doi:10.1124/jpet.108.145672. PMID:18974361.
22. Shen, J.B., Jiang, B., and Pappano, A.J. 2000. Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther. 294(2): 562-570. PMID:10900233.
23. Triggle, D.J. 2007. Calcium channel antagonists: clinical uses - past, present and future. Biochem. Pharmacol. 74(1): 1-9. doi:10.1016/j.bcp. 2007.01.016. PMID:17276408.
24. Williams, M.E., Washburn, M.S., Hans, M., Urrutia, A., Brust, P.F., Prodanovich, P., et al. 1999. Structure and functional characterization of a novel human low-voltage activated calcium channel. J. Neurochem. 72(2): 791-799. doi:10.1046/j.1471-4159.1999.0720791.x. PMID:9930755.
25. Xia, M., Imredy, J.P., Koblan, K.S., Bennett, P., and Connolly, T.M. 2004. State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format. Anal. Biochem. 327(1): 74-81. doi:10.1016/j.ab.2004.01.003. PMID:15033513.