Distinct effects of atypical 1,4-dihydropyridines on 1-methyl-4- phenylpyridinium-induced toxicity

Cell Biochemistry and Function

Volumn 25, Issue 1, 2007, Pages 15-21

  Klimaviciusa, Linda ^a   Klusa, Vija ^a   Duburs, Gunars ^b   Kaasik, Allen ^c   Kalda, Anti ^c   Zharkovsky, Alexander ^c  

^a UNIVERSITY OF LATVIA   (Latvia)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UNIVERSITY OF TARTU   (Estonia)

Author keywords

Atypical 1,4 dihydropyridines; Cerebellar granule cells; MPP+; Neuroprotection

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,4 DIHYDROPYRIDINE DERIVATIVE; CEREBROCRAST; GLUTAPYRONE; NIMODIPINE; TAUROPYRONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; IN VITRO STUDY; MEMBRANE POTENTIAL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

1-METHYL-4-PHENYLPYRIDINIUM; CELL DEATH; CELLS, CULTURED; DIHYDROPYRIDINES; MOLECULAR STRUCTURE; NEURONS; REACTIVE OXYGEN SPECIES;

EID: 33846374439     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1340     Document Type: Article

References (30)

1. Karpova M, Germane S, Cebers G, et al. The anticonvulsant properties of glutapyrone, a new type of derivative of amino acid-containing 1,4-dihydropyridines. Biull Eksp Biol Med 1993; N9: 283-286 (in Russian).
2. Kluša V, Duburs G, Ģermane S, et al. Structure and activity peculiarities of Cerebrocrast (IOS-1.1212), a novel type of CNS-modulating 1,4-dihydropyridines. Proc Latvian Acad Sci, Section B 1992; N9: 51-55.
3. Klimaviciusa L, Klusa V, Duburs G, Kaasik A, Kalda A, Zharkovsky A. Neuroprotective (oxygen-glucose deprivation model) and neurotrophic effects of novel 1,4-dihydropyridine derivatives in cerebellar granule cells. Proc Latvian Acad Sci, Section B 2005; N5: 20-30.
4. Kluša V. Cerebrocrast. Drugs Future 1995; 20: 135-138.
5. Kluša V, Semenova TD, Medvinskaya NI, Fast AE. Cerbrocrast (IOS-1212) normalizes disturbances of learning, attention, emotional behaviour and brain biogenic amine levels in prenatally hypoxized rats. Proc Latvian Acad Sci, Section B 1995; N11(12): 156-161.
6. Karpova MM, Pankov OY, Glebov RN, Dubur GY, Germane SK, Klusa VE. Antiepileptic effects of IOS-1.1212, a novel Mocker of Ca-channels. Biull Eksp Biol Med 1991; N10: 362-365 (in Russian).
7. Klusa V, Ģermane S. Alcoholised maternal rat offspring: model for testing of physical and psycho emotional neurodeficit. Scand J Lab Anim Sci 1996; 23: 403-409.
8. Velena A, Skujins A, Svirskis S, et al. Modification of swelling-contraction-aggregation processes in rat muscle mitochondria by the 1,4-dihydropyridines, cerebrocrast and glutapyrone, themselves and in the presence of azidothymidine. Cell Biochem Funct 1997; 15: 211-220.
9. Poikans J, Tirzitis G, Bisenieks E, et al. The derivatives of 2,6-dimethyl-1,4-dihydroisonicotinic acid and their antiplatelet properties. Eur J Med Chem 1984; 29: 325-328.
10. Adams JD, Jr, Klaidman LK, Leung AC. MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes. Free Radic Biol Med 1993; 15: 181-186.
11. +): reductive activation by NADPH cytochrome P-450 reductase. Biochem Biophys Res Commun 1986; 135: 583-588.
12. Cleeter MW, Cooper JM, Schapira AH. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 1992; 58: 786-789.
13. Gonzalez-Polo RA, Soler G, Alonso JC, Rodriguez-Martin A, Fuentes JM. MPP(+) causes inhibition of cellular energy supply in cerebellar granule cells. Neurotoxicology 2003; 24: 219-225.
14. Mizuno Y, Suzuki K, Sone N, Saitoh T. Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated mitochondria from mouse brains. Neurosci Lett 1987; 81: 204-208.
15. Nicklas WJ, Vyas I, Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 1985; 36: 2503-2508.
16. Gallo V, Ciotti MT, Coletti A, Aloisi F, Levi G. Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc Natl Acad Sci USA 1982; 79: 7919-7923.
17. Tymianski M, Charlton MP, Carlen PL, Tator CH. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 1993; 13: 2085-2104.
18. Oyama Y, Hayashi A, Ueha T, Chikahisa L, Furukawa K. Fluorescent estimation on the effect of Ca2+ antagonists on the oxidative metabolism in dissociated mammalian brain neurons. Brain Res 1993; 610: 172-175.
19. Garner DL, Thomas CA. Organelle-specific probe JC-1 identifies membrane potential differences in the mitochondrial function of bovine sperm. Mol Reprod Dev 1999; 53: 222-229.
20. Reers M, Smiley ST, Mottola-Hartshorn C, Chen A, Lin M, Chen LB. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol 1995; 260: 406-417.
21. Smiley ST, Reers M, Mottola-Hartshorn C, et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 1991; 88: 3671-3675.
22. Dubur GJ, Veveris MM, Veinheimer G, et al. Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)- 1,4-dihydropyridine-3,4-dicarboxilic acid. Arzneim Forschung 1989; 39: 1185-1189.
23. Biseniex EA, Dubur GY, Uldrikis YR, Veveris MM, Kimenis AA, Ivanov EV. 2-(2,6-Dimethyl-2,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide)glutaric acid, its disodium salt and method of their preparation. US Patent No. 4,485,239 27.11.84.; Application no. 536,899, 28.09.83. 1984.
24. Chahine R, Feng J. Protective effect of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart. Arzneimittel Forschung 1998; 48: 360-364.
25. González-Polo RA, Mora A, Clemente N, Sabio G, Centeno F, Soler G. Mechanisms of MPP+ incorporation into cerebellar granule cells. Brain Res Bull 2001; 56: 119-123.
26. Ramsay RR, Singer RP. Energy-dependent uptake of N-methyl-4- phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine, by mitochondria. J Biol Chem 1986; 261: 7585-7587.
27. Huxtable RJ. Physiological actions of taurine. Phys Rev 1992; 72: 101-159.
28. Fernandes MAS, Santos MS, Vicente JAF, et al. Effects of 1,4-dihydrpyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) on mitochondrial bioenergetics and oxidative stress: a comparative study. Mitochondrion 2003; 3: 47-59.
29. Misane I, Klusa V, Dambrova M, et al. "Atypical" neuromodulatory profile of glutapyrone, a representative of a novel 'class' of amino acid-containing dipeptide-mimicking 1,4-dihydropyridine (DHP) compounds: in vitro and in vivo studies. Eur Neuropsychopharmacol 1998; 8: 329-347.
30. Klegeris A, Liutkevicius E, Mikalauskiene G, Duburs G, McGeer PL, Klusa V. Anti-inflammatory effects of cerebrocrast in a model of rat paw oedema and on mononuclear THP-1 cells. Eur J Pharmacol 2002; 441: 203-208.