Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells

Prostaglandins and Other Lipid Mediators

Volumn 91, Issue 1-2, 2010, Pages 30-37

  Lee, Sun Young ^a   Ahn, Ji Hyun ^b   Ko, Kyoung Won ^a   Kim, Jaetaek ^b   Jeong, Seong Whan ^a   Kim, In Kyung ^a   Kim, Jin ^a   Kim, Ho Shik ^a  

^a The Catholic University of Korea   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Apoptosis; Caspase; Cytochrome c; Mitochondria; Prostaglandin A2

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CASPASE 2; CASPASE 3; CASPASE 7; CASPASE 9; CYSTEINE; CYTOCHROME C; GLYCEROL DERIVATIVE; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOCORTIN 5; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PIPERIDINE DERIVATIVE; PROSTAGLANDIN A2; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; PROSTAGLANDIN A; SCAVENGER; THIOL DERIVATIVE;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE PERMEABILITY; DRUG EFFECT; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION;

ANIMALS; APOPTOSIS; CASPASE 3; CELL MEMBRANE PERMEABILITY; CYTOCHROMES C; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; HL-60 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PROSTAGLANDINS A; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS;

EID: 74849085722     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2009.12.003     Document Type: Article

References (41)

1. Straus D.S., and Glass C.K. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21 3 (2001) 185-210
2. Gilroy D.W., Colville-Nash P.R., Willis D., Chivers J., Paul-Clark M.J., and Willoughby D.A. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5 6 (1999) 698-701
3. Honn K.V., and Marnett L.J. Requirement of a reactive alpha, beta-unsaturated carbonyl for inhibition of tumor growth and induction of differentiation by "A" series prostaglandins. Biochem Biophys Res Commun 129 1 (1985) 34-40
4. Rossi A., Kapahi P., Natoli G., et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403 6765 (2000) 103-108
5. 2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. Prostaglandins 52 3 (1996) 143-156
6. 2 induce apoptosis in L1210 cells. FEBS Lett 321 2-3 (1993) 209-214
7. 2 in human hepatocarcinoma SK-HEP-1 cells. FEBS Lett 368 2 (1995) 348-352
8. 2. Biochim Biophys Acta 1448 1 (1998) 115-125
9. 2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol 16 12 (1996) 6654-6660
10. 2. Prostaglandins Other Lipid Mediat 70 1-2 (2002) 169-183
11. Byun H.S., Won M., Park K.A., et al. Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. Exp Mol Med 40 2 (2008) 186-195
12. Akao Y., Otsuki Y., Kataoka S., Ito Y., and Tsujimoto Y. Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes. Cancer Res 54 9 (1994) 2468-2471
13. Bossy-Wetzel E., and Green D.R. Assays for cytochrome c release from mitochondria during apoptosis. Methods Enzymol 322 (2000) 235-242
14. Lim M.L., Minamikawa T., and Nagley P. The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. FEBS Lett 503 1 (2001) 69-74
15. Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 5684 (2004) 626-629
16. Ott M., Gogvadze V., Orrenius S., and Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis 12 5 (2007) 913-922
17. Nencioni A., Lauber K., Grunebach F., et al. Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. J Immunol 171 10 (2003) 5148-5156
18. 2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. Cancer Res 48 10 (1988) 2813-2818
19. Robertson J.D., Enoksson M., Suomela M., Zhivotovsky B., and Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J Biol Chem 277 33 (2002) 29803-29809
20. Tinel A., and Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304 5672 (2004) 843-846
21. Wolf D., and Rotter V. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci USA 82 3 (1985) 790-794
22. Tsujimoto Y., Nakagawa T., and Shimizu S. Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta 1757 9-10 (2006) 1297-1300
23. Antonsson B. Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways. Mol Cell Biochem 256-257 1-2 (2004) 141-155
24. Antignani A., and Youle R.J. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?. Curr Opin Cell Biol 18 6 (2006) 685-689
25. Jeong S.Y., and Seol D.W. The role of mitochondria in apoptosis. BMB Rep 41 1 (2008) 11-22
26. Wei M.C., Zong W.X., Cheng E.H., et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 5517 (2001) 727-730
27. Kinnally K.W., and Antonsson B. A tale of two mitochondrial channels, MAC and PTP, in apoptosis. Apoptosis 12 5 (2007) 857-868
28. Rostovtseva T.K., Tan W., and Colombini M. On the role of VDAC in apoptosis: fact and fiction. J Bioenergy Biomembr 37 3 (2005) 129-142
29. Lai J.C., Tan W., Benimetskaya L., Miller P., Colombini M., and Stein C.A. A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC. Proc Natl Acad Sci USA 103 19 (2006) 7494-7499
30. Hail Jr. N., and Lotan R. Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state. Mol Nutr Food Res 53 1 (2009) 49-67
31. 2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARγ-independent mechanisms. J Immunol 177 8 (2006) 5068-5076
32. 2-glutathione conjugate in L1210 mouse leukemia cells. Biochem Pharmacol 43 5 (1992) 1053-1060
33. Moos P.J., Edes K., and Fitzpatrick F.A. Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. Proc Natl Acad Sci USA 97 16 (2000) 9215-9220
34. Kobayashi M., Ono H., Mihara K., et al. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Genes Cells 11 7 (2006) 779-789
35. Renedo M., Gayarre J., Garcia-Dominguez C.A., et al. Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. Biochemistry 46 22 (2007) 6607-6616
36. Costa N.J., Dahm C.C., Hurrell F., Taylor E.R., and Murphy M.P. Interactions of mitochondrial thiols with nitric oxide. Antioxid Redox Signal 5 3 (2003) 291-305
37. Costantini P., Belzacq A.S., Vieira H.L., et al. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 19 2 (2000) 307-314
38. Larochette N., Decaudin D., Jacotot E., et al. Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp Cell Res 249 2 (1999) 413-421
39. de Pablo M.A., Susin S.A., Jacotot E., et al. Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis 4 2 (1999) 81-87
40. 2 in mitochondria. Biochem J 394 Pt 1 (2006) 185-195
41. Yip K.W., and Reed J.C. Bcl-2 family proteins and cancer. Oncogene 27 50 (2008) 6398-6406