Expression of Reg IV and Hath1 in neuroendocrine neoplasms

Histology and Histopathology

Volumn 25, Issue 1, 2010, Pages 63-72

  Heiskala, Kukka ^a   Arola, Johanna ^a,b   Heiskala, Marja ^a   Andersson, Leif C ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Carcinoid; Hath1; Immunohistochemistry; Neuroendocrine tumor; Reg IV

Indexed keywords

ATOH1 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; LECTIN; MONOCLONAL ANTIBODY; REG4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CYTOLOGY; DIGESTIVE SYSTEM; EPITHELIUM CELL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; INTESTINE TUMOR; MALE; METABOLISM; MIDDLE AGED; NEUROENDOCRINE TUMOR; PATHOLOGY; PHEOCHROMOCYTOMA; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIGESTIVE SYSTEM; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; LECTINS, C-TYPE; MALE; MIDDLE AGED; NEUROENDOCRINE TUMORS; PHEOCHROMOCYTOMA;

MURINAE;

EID: 74749104126     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Arakagi M., Tsuchiya K., Okamoto R., Yoshioka S., Nakamura T., Sakamoto N., Kanai T. and Watanabe M. (2008). Proteosomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun. 368, 923-929.
2. Ben-Arie N., Bellen H.J., Armstrong D.L., McCall A.E., Gordadze P.R., Guo Q., Matzuk M.M. and Zoghbi H.Y. (1997). Math1 is essential for genesis of cerebellar granule neurons. Nature 390, 169-172.
3. Bermingham N.A., Hassan B.A., Price S.D. Vollrath M.A., Ben-Arie N., Eatock R.A., Bellen H.J., Lysakowski A. and Zoghbi H.Y. (1999). Math1: an essential gene for the generation of inner ear hair cells. Science 284, 1837-1841.
4. Bishnupuri K.S., Luo Q., Murmu N., Houchen C.W., Anant S. and Dieckgraefe B.K. (2006). Reg IV Activates the Epidermal Growth Factor Receptor/Akt/AP-1 Signaling Pathway in Colon Adenocarcinomas. Gastroenterology 130, 137-149.
5. Chen W., Cacciabue-Rivolta D.I., Moore H.D. and Rivolta M.N. (2007). The human fetal cochlea can be a source for auditory progenitors/stem cell isolation. Hear. Res. 233, 23-29.
6. Gironella M., Iovanna J.L., Sans M., Gil F., Peñalva M., Closa D., Miquel R., Piqué J.M. and Panés J. (2005). Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease. Gut 54, 1244-1253.
7. Hartupee J.C., Zhang H., Bonaldo M.F., Soares M.B. and Dieckgraefe B.K. (2001). Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim. Biophys. Acta 1518, 287-293.
8. Heiskala K., Giles-Komar J., Heiskala M. and Andersson L.C. (2006). High expression of RELP (Reg IV) in neoplastic goblet cells of appendiceal mucinous cystadenoma and pseudomyxoma peritonei. Virchows Arch. 448, 295-300.
9. Kämäräinen M., Heiskala K., Knuutila S., Heiskala M., Winqvist O. and Andersson L.C. (2003). RELP, a novel human Reg-Like Protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. Am. J. Pathol. 163, 11-20.
10. Leonard J.H., Cook A.L., van Gele M., Boyle G.M., Inglis K.J., Speleman F. and Sturm R.A. (2002). Proneural and proneuro-endocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int. J. Cancer 101, 103-110.
11. Leow C.C., Polakis P. and Gao W.Q. (2005). A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. Ann. N.Y. Acad. Sci. 1059, 174-183.
12. Machold R.P., Kittell D.J. and Fishell G.J. (2007). Antagonism between Notch and bone morphogenic protein receptor signalling regulates neurogenesis in the cerebellar rhombic lip. Neural. Dev. 2, 5.
13. Mitani Y., Oue N., Matsumura S., Yoshida K., Noguchi T., Ito M., Tanaka S., Kuniyasu H., Kamata N. and Yasui W. (2007). Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene 26, 4383-4393.
14. Nanakin A., Fukui H., Fujii S., Sekikawa A., Kanda N., Hisatsune H., Seno H., Konda Y., Fujimori T. and Chiba T.(2007). Expression of the REG IVgene in ulcerative colitis. Lab. Invest. 87, 304-314.
15. Ohara S., Oue N., Matsubara A., Mita K., Hasegawa Y., Hayashi T., Usui T., Amatya V.J., Takeshima Y., Kuniyasu H. and Yasui W. (2008). Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer. Cancer Sci. 99, 1570-1577.
16. Oue N., Hamai Y., Mitani Y., Matsumura S., Oshimo Y., Aung P.P., Kuraoka K., Nakayama H. and Yasui W. (2004). Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64, 2397-2405.
17. Oue N., Mitani Y., Aung P.P., Sakakura C., Takeshima Y., Kaneko M., Noguchi T., Nakayma H. and Yasui W. (2005). Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J. Pathol. 207, 185-198.
18. Park E.T., Oh H.K., Gum J.R., Crawley S.C., Kakar S., Engel J., Leow C.C., Gao W.Q. and Kim Y.S. (2006). HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin. Cancer Res. 12, 5403-5410.
19. Schonhoff S.E., Giel-Moloney M. and Leiter A.B. (2004). Minireview: Development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644.
20. Schröder N., Sekhar A., Geffers I., Müller J., Dittrich-Breiholz O., Kracht M., Wedemeyer J. and Gossler A.(2006). Identification of mouse genes with highly specific expression patterns in differentiated intestinal epithelium. Gastroenterology 130, 902-907.
21. Schroyer N.F., Helmrath M.A., Wang V.Y.C., Antalffy B., Henning S.J. and Zoghbi H.Y. (2007). Intestine-specific ablation of Mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132, 2478-2488.
22. Takehara A., Eguchi H., Ohigashi H., Ishikawa O., Kasugai T., Hosokawa M., Katagiri T., Nakamura Y. and Nakagawa H. (2006). Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Sci. 97, 1191-1197.
23. Tsuchiya K., Nakamura T., Okamoto R., Kanai T. and Watanabe M. (2007). Reciprocal targeting of Hath1 and β-catenin by Wnt glycogen synthase kinase 3b in human colon cancer. Gastroenterology 132, 208-220.
24. Violette S., Festor E., Pandrea-Vasile I., Mitchell V., Adida C., Dussaulx E., Lacorte J.M., Chambaz J., Lacasa M. and Lesuffleur T. (2003). Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int. J. Cancer 103, 185-193.
25. Westerman B.A., Breuer R.H.J., Poutsma A., Chhatta A., Noorduyn L.A., Koolen M.G., Postmus P.E., Blankenstein M.A. and Oudejans C.B. (2007). Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. Int. J. Biol. Markers 22, 114-123.
26. Yang Q., Bermingham N.A., Finegold M.J. and Zoghbi H.Y. (2001). Requirement of Math1 Cell Lineage Commitment in the Mouse Intestine. Science 294, 2155-2158.
27. Zhang Y., Lai M., Lv B., Gu X., Wang H., Zhu Y., Zhu Y., Shao L. and Wang G. (2003a). Overexpression of Reg IV in colorectal adenoma. Cancer Lett. 200, 69-76.
28. Zhang Y., Ding L. and Lai M. (2003b). Reg gene family and human diseases. World J. Gastroenterol. 9, 2635-2641.