Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 2, 2010, Pages 397-406

  Xia, M ^a   Li, G ^a   Ma, J ^a   Ling, W ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

CD40 ligand; Endothelial cells; PI3K; Reactive oxygen species

Indexed keywords

CD40 LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ZETA; PROTEIN P47PHOX; PROTEIN P85; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DISEASE MODEL; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD40; CD40 LIGAND; CELLS, CULTURED; CHROMONES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MORPHOLINES; NADPH OXIDASE; OXIDATIVE STRESS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; VASODILATION;

EID: 74749096874     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2009.03683.x     Document Type: Article

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