Inhibitory action of hydroxytyrosol from glucose-induced insulin deficient and pancreas and liver toxicity in vitro

Current Trends in Biotechnology and Pharmacy

Volumn 3, Issue 4, 2009, Pages 352-361

  Hamden, Khaled ^a   Allouche, Nourreddine ^a   Damak, Mohamed ^a   Carreau, Serge ^b   Elfeki, Abdelfattah ^a  

^a UNIVERSITY OF SFAX   (Tunisia)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

Antioxidant; Glucose toxicity; Hydroxytyrosol; Insulin; Liver slices; Pancreas

Indexed keywords

CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROXYTYROSOL; INSULIN; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; INSULIN DEFICIENCY; INSULIN RELEASE; LIPID PEROXIDATION; LIVER SLICE; LIVER TOXICITY; MALE; NONHUMAN; PANCREAS; RAT;

EID: 74749086671     PISSN: 09738916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Roglic, G., Unwin, N., Bennett, P.H., Mathers, C., Tuomilohto, J., Nag, S., Connolly, V. and King, H. (2005). The burden of mortality attributable to diabetes: realistic estimate for the year 2000. Diabetes Care, 28: 2130-2135.
2. Zulewski, H. (2006). Stem cells with potential to generate insulin-producing cells in man. Swiss Med Wkly, 136: 647-654.
3. Santos, N.A.G., Medina, W.S.G., Martins, N.M., Carvalho Rodrigues, M.A., Curti, C. and Santos, A.C. (2008). Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs. Toxicology in Vitro, 22: 1820-1824.
4. Ghosh, J., Das, J., Manna, P. and Sil, P.C. (2008). Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicology in Vitro, 22: 1918-1926.
5. Hamden, K., Boujbiha, M.A., Masmoudi, H., Makni-Ayadi, F., Jamoussi, K. and Elfeki, A. (2009). Combined vitamins (C&E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomedicine Pharmacotherapy, 63: 1-5.
6. Hamden, K., Carreau, S., Jamoussi, K., Ayadi, F., Garmazi, F. and Elfeki, A. (2008). Inhibitory effects of 1? 2, 5 dihydroxyvitaminD3 and ajuga iva extract on oxidative stress toxicity and hypofertility in diabetic rat testes. Journal of physiology and biochemistry (In press).
7. Nelson, S.K., Bose, S.K., Grunwald, G.K., Myhill, P. and Cord, J.M. (2006). The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy. Free radical Biology & Medicine 15, 341 - 347.
8. Thirupathi, K., Krishna, D.R., Ravi Kumar, B., Apparao, A.V.N. and Krishna Mohan, G. (2009). Hepatoprotective effect of leaves of Balanites roxburghii against carbon tetrachloride-induced hepatic damage in rats. Current Trends in Biotechnology and Pharmacy, 3: 219-224.
9. Gayathri, M. and Kannabiran K. (2008). Ameliorative potential of aqueous extract of Pterocarpus marsupium Roxb bark on diabetes associated metabolic alterations. Current Trends in Biotechnology and Pharmacy, Vol. 2 (2): 327 -333.
10. Dudley, J.I., Lekli, I., Mukherjee, S., Das, M., Bertelli, A.A. and Das, D.K. (2008). Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. Journal of Agricultural and Food Chemistry, 56: 9362-73.
11. Mukherjee, S., Lekli, I., Gurusamy, N., Bertelli, A.A.A. and Das, D.K. (2008). Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol and hydroxytyrosol Journal of Agricultural and Food Chemistry (In press).
12. Zhang, X., Jiang, L., Geng, C., Yoshimura, H. and Zhong, L. (2008). Inhibition of acrylamide genotoxicity in human liverderived HepG2 cells by the antioxidant hydroxytyrosol. Chemico-Biological Interactions, 176: 173-178.
13. Deiana, M., Incani, A., Rosa, A., Corona, G., Atzeri, A., Loru, D., Melis, M.P. and Dessì, M.A. (2008). Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H2O2 induced lipid peroxidation in renal tubular epithelial cells. Food and Chemical Toxicology , 46: 2984-2990.
14. Visioli, F., Bellomo, G. and Galli, C. (1998). Free radical-scavenging properties of olive oil polyphenols. Biochemical and Biophysical Research Communications, 247: 60-4.
15. Covas, M.I., de la Torre, K., Farré-Albaladejo, M., Kaikkonen, J., Fitó, M., López-Sabater, C., Pujadas-Bastardes, M.A., Joglar, J., Weinbrenner, T., Lamuela-Raventós, R.M and de la Torre, R. (2006). Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radical Biology & medicine 40:608-16.
16. Hannan, J.M.A., Marenah, L., Ali, L., Rokeya, R., Flatt, P.R. and Abdel-Wahab, Y.H. (2006). Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic b-cells. Journal of Endocrinology, 192: 159-168.
17. Mokuda, O., Tanaka, H., Hayashi, T., Ooka, H. and Okazaki, R. (2004). Gliclazide at a lower concentration than therapeutic dose increases the sensitivity of insulin secretion to glucose in perfused rat pancreas. Diabetes & Metabolism, 30:193-6.
18. Allouche, N., Fki, I. and Sayadi, S. (2004). Towards a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters. Journal of Agricultural and Food Chemistry, 52: 267-273.
19. Buege, J.A. and Aust, S.D. (1984). Microsomal lipid peroxidation. Methods in Enzymology, 105: 302-310.
20. Aebi, H. (1984). Catalase in vitro. Methods in Enzymology, 105:121-26.
21. Marklund, S. and Marklund, G. (1975). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase. European Journal of Biochemistry, 47: 469-74.
22. Pagila, D.E. and Valentine, W.N. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of laboratory and Clinical Medicine, 70: 158-169.
23. Ellman, G.C. (1952). Tissue sulfhydryl groups. Arch Biochem Biophys., 82: 70-7.
24. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with Folin phenol reagent. The Journal of Biological Chemistry, 193: 265-275.
25. Gelain, D.P., de Bittencourt Pasquali, M.A., Caregnato, F.F., Zanotto-Filho, A. and Moreira, J.C.F. (2008). Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species. Toxicology in Vitro, 22:1123-1127.
26. Ha, H. and Lee, H.B. (2000). Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int., 77:19-25.
27. Chai, W., Chen, J., Wang, H., Shen, J., Ma, L. and Ma, X. (2000). The effects of glucose and insulin in oxidized low density lipoprotein on apoptosis in vascular endothelial cells. Chinese Medical Journal, 113: 903-906.
28. Henquin, J.C., Debuyser, A., Drews, G. and Plant, T.D. (1992). Regulation of K+ permeability and membrane potential in insulin-secretory cells. In Nutrient Regulation of Insulin Secretion Ed. PR Flatt. London: Porland 173-192.
29. Rout SP, Chowdary K. A., Kar D. M. and Das L. (2009). Plants as source of novel Anti-Diabetic Drug: Present Scenario and Future Perspectives. Current Trends in Biotechnology and Pharmacy, 3(1): 37-55.
30. De Lucia, M., Panzella, L., Pezzella, A., Napolitano, A. and d'Ischia, M. (2006). Oxidative chemistry of the natural antioxidant hydroxytyrosol: hydrogen peroxide-dependent hydroxylation and hydroxyquinone/o-quinone coupling pathways. Tetrahedron, 62: 1273-1278.
31. Erkoc, F., Keskin, N. and Erkoc, S. (2003). Theoretical investigation of hydroxytyrosol and its radicals. Journal of Molecular Structure, 625: 87-94.
32. Grasso, S., Siracusa, L., Spatafora, C., Renis, M. and Tringali, C. (2007). Hydroxytyrosol lipophilic analogues: Enzymatic synthesis, radical scavenging activity and DNA oxidative damage protection. Bioorganic & Medicinal Chemistry, 35: 137-152.
33. González-Santiago M, Martín-Bautista E, Carrero JJ, Fonollá J, Baró L, Bartolomé MV, Gil-Loyzaga P, López-Huertas E. Onemonth administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development. Therosclerosis. 188:35-42.
34. Casalino, E., Calzaretti, G., Sblano, C., Landriscina, V., Tecce, M.F. and Landriscina, C. (2000). Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats. Comparative Biochemistry and Physiology, 133:625-632.
35. O'Dowd, Y., Driss, F., My-Chan Dang, P., Elbim, C., Gougerot-Pocidalo, M.A., Pasquiera, C. and El-Benna, J . (2008). Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochemical Pharmacology, 68:2003-2008.