Gliclazide at a lower concentration than therapeutic dose increases the sensitivity of insulin secretion to glucose in perfused rat pancreas

Diabetes and Metabolism

Volumn 30, Issue 2, 2004, Pages 193-196

  Mokuda, O ^a,b   Tanaka, H ^a   Hayashi, T ^a   Ooka, H ^a   Okazaki, R ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

Author keywords

Gliclazide; Glucose; Insulin secretion; Isolated perfused rat pancreas; Sulfonylurea

Indexed keywords

GLIBENCLAMIDE; GLICLAZIDE; GLUCOSE; INSULIN; RINGER ACETATE; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; GLUCOSE METABOLISM; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; ISOLATED ORGAN; MALE; NONHUMAN; PANCREAS PERFUSION; PATHOPHYSIOLOGY; RAT; STATISTICAL SIGNIFICANCE;

EID: 2642536042     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(07)70107-6     Document Type: Article

References (18)

1. Kadowaki S, Taminato T, Chiba T, Nozawa M, Fujita T, Norman AW. Effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration. Endocrinology, 1983, 122, 2187-92.
2. Ward K, Beard JC, Halter JB, Pfeifer MA, Porte D. Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care, 1984, 7, 491-502.
3. Banergi MA, Lebovitz HE. Remission in non-insulin-dependent diabetes mellitus: clinical characteristics of remission and relapse in black patients. Medicine (Baltimore), 1990, 69, 176-85.
4. Grandmottet P, Narboni G, Schwager JC, Betchel P, Sandos M, Vandel B. Trois observations d'hypoglycémie au cours du traitement par le gliclazide: apport de la pharmacocinétique a l'élaboration d'hypothèses pathogéniques. Ann Med Intern, 1977, 128, 759-62.
5. Grodsky GM, Batts AA, Benett LL, Vcella C, McWilliams NB, Smith DF. Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Am J Physiol, 1963, 205, 638-44.
6. Matchinsky FM, Landgraf R, Ellerman J, Kotler-Brajtburg J. Glucoreceptor mechanisms in islets of Langerhans. Diabetes, 1972, 28, 555-69.
7. Robertson RP, Porte D. The glucose receptor: A defective mechanism in diabetes mellitus distinct from the beta-adrenergic receptor. J Clin Invest, 1973, 52, 870-7.
8. Ikeda T, Takeuchi T, Ito Y, Mokuda O, Tominaga M, Mashiba H. Potentiating effect of glibenclamide on the occurrence of streptozotocin diabetes. Horm Metab Res, 1986, 18, 352.
9. Hiramatsu S, Höög A, Möller C, Grill V. Treatment with diazoxide causes prolonged improvement of B-cell function in rat islets transplanted to a diabetic environment. Metabolism, 2000, 49, 657-61.
10. Gregorio F, Ambrosi F, Cristallini S, Filipponi P, Santeusanio F. Effects of glimepiride on insulin and glucagon release from isolated rat pancreas at different glucose concentrations. Acta Diabetol, 1996, 33, 25-9.
11. 2+ regulation prevail over changes in insulin content. B J Pharmacol, 1999, 127, 1883-91.
12. Groop LC, Ratheiser K, Lui L, et al. Effect of sulfonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-responsive study. Acta Diabetol, 1991, 28, 162-8.
13. Huges SD, Quude C, Johnson JH, Ferber S, Newgard CB. Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulinsecretion. Relationship to glucose metabolism. J Biol Chem, 1993, 268, 15205-12.
14. Katagiri H, Asano T, Ishihara H, et al. Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet, 1992, 340, 1316-7.
15. Porzio O, Marlier LNJL, Federici M, et al. GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea. Mol Cell Endocrinol, 1999, 153, 155-61.
16. Proks P, Reimann F, Green N, Gribble F, Ashcroft F. Sulfonylurea stimulation of insulin secretion. Diabetes, 2002, 51, S368-76.
17. Gribble FM, Tucker SJ, Seino S, Ashcroft FM. Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. Diabetes, 1998, 47, 1412-8.
18. Gribble FM, Ashcroft FM. Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to glucose. Diabetologia, 1999, 42, 845-8.