Increased oral AUC of baicalin in streptozotocin-induced diabetic rats due to the increased activity of intestinal-glucuronidase

Planta Medica

Volumn 76, Issue 1, 2010, Pages 70-75

  Liu, Li ^a   Deng, Yuan Xiong ^a,b   Liang, Yan ^a   Pang, Xiao Yan ^a   Liu, Xiao Dong ^a   Liu, Yao Wu ^a   Yang, Jian Song ^c   Xie, Lin ^a   Wang, Guang Ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

^c CERTARA UK LIMITED   (United Kingdom)

Author keywords

Baicalin; Diabetes; Glucuronidase; Pharmacokinetics; Scutellariae radix

Indexed keywords

BAICALEIN; BAICALIN; BETA GLUCURONIDASE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXPOSURE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; ENZYME ACTIVITY; ILEUM; INTESTINE; INTESTINE ABSORPTION; INTESTINE MUCOSA; LIVER METABOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; RAT; STREPTOZOCIN DIABETES; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; FLAVANONES; FLAVONOIDS; GLUCURONIDASE; HYDROLYSIS; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINES; MALE; PERMEABILITY; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SCUTELLARIA BAICALENSIS;

RATTUS; SCUTELLARIA RADIX;

EID: 74549193938     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185946     Document Type: Article

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