Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation

European Journal of Pharmaceutical Sciences

Volumn 26, Issue 1, 2005, Pages 114-123

  Yu, Chul Kim ^a   Ae, Kyung Lee ^a   Joo, Hyun Lee ^a   Lee, Inchul ^b   Duk, Chul Lee ^c   So, Hee Kim ^d   Sang, Geon Kim ^a   Myung, Gull Lee ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Gangneung Wonju National University   (South Korea)

Author keywords

1,3 DMU; Alloxan; CYP1A2; CYP2E1; Diabetes mellitus; Pharmacokinetics; Rats; Streptozotocin; Theophylline

Indexed keywords

1,3 DIMETHYLURIC ACID; AMINOPHYLLINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; THEOPHYLLINE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG CLEARANCE; DRUG METABOLISM; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ADMINISTRATION, ORAL; ALLOXAN; AMINOPHYLLINE; ANIMALS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INDUCTION; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STREPTOZOCIN; THEOPHYLLINE; URIC ACID;

EID: 23244434003     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.05.004     Document Type: Article

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