Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. EXAMPLE: Acrylamide (CAS No. 79-06-1)

Food and Chemical Toxicology

Volumn 48, Issue SUPPL. 1, 2010, Pages

  Michael Bolger, P ^a   Leblanc, Jean Charles ^b   Woodrow Setzer, R ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b French Food Safety Agency   (France)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Acrylamide; Margin of Exposure (MoE)

Indexed keywords

ACRYLAMIDE;

ARTICLE; BREAST TUMOR; CARCINOGENICITY; DIETARY INTAKE; DOSE RESPONSE; ENDOMETRIUM CARCINOMA; FOLLICULAR CARCINOMA; GENOTOXICITY; GLIOMA; HUMAN; HYPOPHYSIS ADENOMA; MESOTHELIOMA; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA; RISK ASSESSMENT; THYROID TUMOR;

ACRYLAMIDE; ANIMALS; CARCINOGENS; DATA INTERPRETATION, STATISTICAL; DIET; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; MODELS, STATISTICAL; MUTAGENS; NEOPLASMS; RATS;

ANIMALIA;

EID: 74549131286     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.11.040     Document Type: Article

References (32)

1. Abramsson-Zetterberg L. The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat. Res. 535 2 (2003) 215-222
2. Beer M.U., Schlatter J., Dudler V., and Zoller O. Fried potatoes and human cancer. Int. J. Cancer 108 (2004) 634-635
3. Bosetti C., Talamini R., Levi F., Negri E., Franceschi S., Airoldi L., and La Vecchia C. Fried foods: a risk factor for laryngeal cancer?. Br. J. Cancer 87 11 (2003) 1230-1233
4. Doerge D.R., Young J.F., McDaniel L.P., Twaddle N.C., Churchwell M.I., and Beland F.A. Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice. Toxicol. Appl. Pharmacol. 202 (2005) 258-267
5. Doerge D.R., Young J.F., McDaniel L.P., Twaddle N.C., and Churchwell M.I. Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats. Toxicol. Appl. Pharmacol. 208 (2005) 199-209
6. Doerge D.R., Gamboa da Costa G., McDaniel L.P., Twaddle N.C., and Churchwell M.I. DNA adducts derived from administration of acrylamide and glycidamide to mice and rats. Mutat. Res. 580 (2005) 131-141
7. Fennell T.R., Sumner S.C., Snyder R.W., Burgess J., Spicer R., Bridson W.E., and Friedman M.A. Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol. Sci. 85 (2005) 447-459
8. Friedman M.A., Dulak L.H., and Stedham M.A. A lifetime oncogenicity study in rats with acrylamide. Fundam. Appl. Toxicol. 27 (1995) 95-105
9. Gamboa da Costa G., Churchwell M.I., Hamilton L.P., Beland F.A., Marques M.M., and Doerge D.R. DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chem. Res. Toxicol. 16 (2003) 1328-1337
10. Ghanayem B.I., Witt K.L., El-Hadri L., Hoffler U., Kissling G.E., Shelby M.D., and Bishop J.B. Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect. Biol. Reprod. 72 (2005) 157-163
11. Hashimoto K., and Tanii H. Mutagenicity of acrylamide and its analogues in Salmonella typhimurium. Mutat. Res. 158 (1985) 129-133
12. Hogervorst J., Schouten L., Konings E., Goldbohm R.A., and van den Brandt P.A. A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian and breast cancer. Cancer Epi. Biomarkers Prev. 16 (2007) 2304-2313
13. International Agency for Research on Cancer (IARC). Ethylene Oxide, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Some Industrial Chemical vol. 60 (1994), IARC, Lyon pp. 73-159
14. International Agency for Research on Cancer (IARC). Acrylamide, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Some Industrial Chemicals vol. 60 (1994), IARC, Lyon pp. 389-433
15. Johnson K.A., Gorzinski S.J., Bodner K.M., Campbell R.A., Wolf C.H., Friedman M.A., and Mast R. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol. 85 (1986) 154-168
16. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 2006. Evaluation of certain food contaminants, 64th Report. Available from: .
17. Lafferty J.S., Kamendulis L.M., Kaster J.L., Jiang J., and Klaunig J.E. Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat. Toxicol. Lett. 154 (2004) 95-103
18. Manière I., Godard T., Doerge D.R., Churchwell M.I., Guffroy M., Laurentie M., and Poul J.-M. DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide. Mutat. Res. 580 (2005) 119-129
19. Mucci L.A., Dickman P.W., Steineck G., Adami H.O., and Augustsson K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br. J. Cancer 88 (2003) 84-89
20. Mucci L.A., Dickman P.W., Steineck G., Adami H.O., and Augustsson K. Reply: dietary acrylamide and cancer risk: additional data on coffee. Br. J. Cancer 89 (2003) 775-776
21. Mucci L.A., Lindblad P., Steineck G., and Adami H.O. Dietary acrylamide and risk of renal cell cancer. Int. J. Cancer 109 (2004) 774-776
22. Olesen P.T., Olsen A., Frandsen H., Frederiken K., Oversad K., and Tjonneland A. Acrylamide exposure and incidence of breast cancer among postmenopausal women in the Danish diet, cancer and health study. Int. J. Cancer 122 (2008) 2094-2100
23. Park J., Kamendulis L.M., Friedman M.A., and Klaunig J.E. Acrylamide-induced cellular transformation. Toxicol. Sci. 65 (2002) 177-183
24. Paulsson B., Athanassiadis I., Rydberg P., and Törnqvist M. Hemoglobin adducts from glycidamide: acetonization of hydrophilic groups for reproducible gas chromatography/tandem mass spectrometric analysis. Rapid Commun. Mass Spectrom. 17 (2003) 1859-1865
25. Pelucchi C., Franceschi S., Levi F., Trichopoulos D., Bosetti C., Negri E., and La Vecchia C. Fried potatoes and human cancer. Int. J. Cancer 105 (2003) 558-560
26. Pelucchi C., La Vecchia C., Franceschi S., and Levi F. Re: fried potatoes and human cancer. Int. J. Cancer 108 (2004) 636-637
27. Rice, J.M., 2005. The carcinogenicity of acrylamide. Mutat. Res. 580, 3-20.
28. Rice J.M., and Wilbourn J.D. Tumors of the nervous system in carcinogen hazard evaluation. Toxicol. Pathol. 28 (2000) 202-214
29. Tareke E., Rydberg P., Karlsson P., Eriksson S., and Törnqvist M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem. 50 (2002) 4998-5006
30. Tornqvist M., Paulsson B., Vikstrom A., and Granath F. Approach for cancer risk estimation of acrylamide in food on the basis of animal cancer tests and in vivo dosimetry. J. Agric. Food Chem. 56 15 (2008) 6004-6012
31. Vesper, H.W., Licea-Perez, H., Meyers, T., Ospina, M., Meyers, G.L., 2004. Pilot study on the impact of potato chips consumption on biomarkers of acrylamide exposure. Am. Chem. Soc. Spring Meeting Abstract AGFD 81.
32. Zeiger E., Recio L., Fennell T.R., Haseman J.K., Snyder R.W., and Friedman M. Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamide. Toxicol. Sci. 107 1 (2009) 247-257