Susceptibility to paratuberculosis infection in cattle is associated with single nucleotide polymorphisms in Toll-like receptor 2 which modulate immune responses against Mycobacterium avium subspecies paratuberculosis

Preventive Veterinary Medicine

Volumn 93, Issue 4, 2010, Pages 305-315

  Koets, A ^a,b   Santema, W ^a,b   Mertens, H ^a   Oostenrijk, D ^a   Keestra, M ^a   Overdijk, M ^a   Labouriau, R ^c   Franken, P ^d   Frijters, A ^e   Nielen, M ^b   Rutten, V ^a,f  

^a Department of Infectious Diseases and Immunology   (Netherlands)

^b Faculty of Veterinary Medicine   (Netherlands)

^c DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^d GD ANIMAL HEALTH   (Netherlands)

^e CRV   (Netherlands)

^f UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Genetic susceptibility; Innate immunity; Johne's disease; Paratuberculosis; Toll like receptor 2

Indexed keywords

TOLL LIKE RECEPTOR 2;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CASE CONTROL STUDY; CATTLE; CATTLE DISEASE; FEMALE; GENETIC SCREENING; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MYCOBACTERIUM PARATUBERCULOSIS; PARATUBERCULOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; ANIMALS; CASE-CONTROL STUDIES; CATTLE; CATTLE DISEASES; FEMALE; GENETIC TESTING; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; TOLL-LIKE RECEPTOR 2;

ANIMALIA; BOS; BOVIDAE; BOVINAE; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS;

EID: 74449093648     PISSN: 01675877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prevetmed.2009.11.008     Document Type: Article

References (46)

1. Aliprantis A.O., Yang R.B., Mark M.R., Suggett S., Devaux B., Radolf J.D., Klimpel G.R., Godowski P., and Zychlinsky A. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 (1999) 736-739
2. Alzuherri H.M., Little D., and Clarke C.J. Altered intestinal macrophage phenotype in ovine paratuberculosis. Res. Vet. Sci. 63 (1997) 139-143
3. Ben-Ali M., Barbouche M.R., Bousnina S., Chabbou A., and Dellagi K. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clin. Diagn. Lab. Immunol. 11 (2004) 625-626
4. Burnham K.P., and Anderson D.R. Model Selection and Multimodel Inference: A Practical-Theoretic Approach. 2nd ed. (2002), Springer-Verlag. 0-387-95364-7
5. Bochud P.Y., Hawn T.R., and Aderem A. Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J. Immunol. 170 (2003) 3451-3454
6. Buwitt-Beckmann U., Heine H., Wiesmuller K.H., Jung G., Brock R., Akira S., and Ulmer A.J. Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur. J. Immunol. 35 (2005) 282-289
7. Casanova J.L., and Abel L. Genetic dissection of immunity to mycobacteria: the human model. Annu. Rev. Immunol. 20 (2002) 581-620
8. Coussens P.M. Model for immune responses to Mycobacterium avium subspecies paratuberculosis in cattle. Infect. Immun. 72 (2004) 3089-3096
9. Estonba A., Iriondo M., Oyanguren O., Garrido J.M., Geijo M.V., Sevilla I., and Juste R.A. Bovine 3′-UTR (GT11) variant of the NRAMP1 gene under-represented among paratuberculosis seropositive cattle. Proceedings of the 8th International Colloquium on Paratuberculosis (2005)
10. Gonda M.G., Chang Y.M., Shook G.E., Collins M.T., and Kirkpatrick B.W. Genetic variation of Mycobacterium avium ssp. paratuberculosis infection in US Holsteins. J. Dairy Sci. 89 (2006) 1804-1812
11. Gonda M.G., Kirkpatrick B.W., Shook G.E., and Collins M.T. Identification of a QTL on BTA20 affecting susceptibility to Mycobacterium avium ssp. paratuberculosis infection in US Holsteins. Anim. Genet. 38 (2007) 389-396
12. Greenstein R.J. Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease. Lancet Infect. Dis. 3 (2003) 507-514
13. Haughton D.M.A. On the choice of a model to fit data from an exponential family. Ann. Stat. 16 (1988) 342-355
14. Heaton M.P., Grosse W.M., Kappes S.M., Keele J.W., Chitko-McKown C.G., Cundiff L.V., Braun A., Little D.P., and Laegreid W.W. Estimation of DNA sequence diversity in bovine cytokine genes. Mamm Genome 12 (2001) 32-37
15. Hostetter J., Steadham E., Haynes J., Bailey T., and Cheville N. Phagosomal maturation and intracellular survival of Mycobacterium avium subspecies paratuberculosis in J774 cells. Comparat. Immunol., Microbiol. Infect. Dis. 26 (2003) 269-283
16. Jang S., Uematsu S., Akira S., and Salgame P. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J. Immunol. 173 (2004) 3392-3397
17. Jorgensen J.B. An improved medium for culture of Mycobacterium paratuberculosis from bovine faeces. Acta Vet. Scand. 23 (1982) 325-335
18. Kalinski P., Hilkens C.M., Wierenga E.A., and Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20 (1999) 561-567
19. Kang T.J., and Chae G.T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol. Med. Microbiol. 31 (2001) 53-58
20. Keestra A.M., de Zoete M.R., van Aubel R.A., and van Putten J.P. The central leucine-rich repeat region of chicken TLR16 dictates unique ligand specificity and species-specific interaction with TLR2. J. Immunol. 178 (2007) 7110-7119
21. Koets A., Rutten V., Hoek A., van Mil F., Muller K., Bakker D., Gruys E., and van Eden W. Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect. Immun. 70 (2002) 3856-3864
22. Koets A.P., Adugna G., Janss L.L., van Weering H.J., Kalis C.H., Wentink G.H., Rutten V.P., and Schukken Y.H. Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. J. Dairy Sci. 83 (2000) 2702-2708
23. Koets A.P., Rutten V.P., Hoek A., Bakker D., van Zijderveld F., Muller K.E., and van Eden W. Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis. Vet. Immunol. Immunopathol. 70 (1999) 105-115
24. Kuehnel M.P., Goethe R., Habermann A., Mueller E., Rohde M., Griffiths G., and Valentin-Weigand P. Characterization of the intracellular survival of Mycobacterium avium ssp. paratuberculosis: phagosomal pH and fusogenicity in J774 macrophages compared with other mycobacteria. Cell Microbiol. 3 (2001) 551-566
25. Labouriau, R., Sørensen, P., Juul-Madsen, H.R., 2008. An efficient strategy to characterize alleles and complex haplotypes using DNA-markers. arXiv:0804.1690v1 [Stat.AP].
26. Langelaar M.F., Weber C.N., Overdijk M.B., Muller K.E., Koets A.P., and Rutten V.P. Cytokine gene expression profiles of bovine dendritic cells after interaction with Mycobacterium avium ssp. paratuberculosis (M.a.p.), Escherichia coli (E. coli) or recombinant M.a.p. heat shock protein 70. Vet. Immunol. Immunopathol. 107 (2005) 153-161
27. Lai E., Riley J., Purvis I., and Roses A. A 4-Mb high density single nucleotide polymorphism based map around human APOE. Genomics 54 (1998) 31-38
28. Lorenz E., Mira J.P., Cornish K.L., Arbour N.C., and Schwartz D.A. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun. 68 (2000) 6398-6401
29. Ogus A.C., Yoldas B., Ozdemir T., Uguz A., Olcen S., Keser I., Coskun M., Cilli A., and Yegin O. The Arg753GLn polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur. Respir. J. 23 (2004) 219-223
30. Pfaffl M.W., Horgan G.W., and Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30 (2002) e36
31. Pinedo P.J., Buergelt C.D., Donovan G.A., Melendez P., Morel L., Wu R., Langaee T.Y., and Rae D.O. Association between CARD15/NOD2 gene polymorphisms and paratuberculosis infection in cattle. Vet. Microbiol. (2008)
32. Quesniaux V., Fremond C., Jacobs M., Parida S., Nicolle D., Yeremeev V., Bihl F., Erard F., Botha T., Drennan M., Soler M.N., Le Bert M., Schnyder B., and Ryffel B. Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect. 6 (2004) 946-959
33. R Development Core Team, 2008. R: A Language and Environment for Statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R-project.org.
34. Rozen S., and Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S., and Misener S. (Eds). Bioinformatics Methods and Protocols: Methods in Molecular Biology (2000), Humana Press, Totowa, NJ 365-386
35. Smirnova I., Hamblin M.T., McBride C., Beutler B., and Di Rienzo A. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics 158 (2001) 1657-1664
36. Smirnova I., Poltorak A., Chan E.K., McBride C., and Beutler B. Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4). Genome Biol. 1 (2000) RESEARCH002
37. Strober W., Murray P.J., Kitani A., and Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 6 (2006) 9-20
38. Wang D.G., Fan J.B., Siao C.J., Berno A., Young P., Sapolsky R., Ghandour G., Perkins N., Winchester E., Spencer J., Kruglyak L., Stein L., Hsie L., Topaloglou T., Hubbell E., Robinson E., Mittmann M., Morris M.S., Shen N., Kilburn D., Rioux J., Nusbaum C., Rozen S., Hudson T.J., Lipshutz R., Chee M., and Lander E.S. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280 (1998) 1077-1082
39. Weckx S., Del-Favero J., Rademakers R., Claes L., Cruts M., De Jonghe P., Van Broeckhoven C., and De Rijk P. novoSNP, a novel computational tool for sequence variation discovery. Genome Res. 15 (2005) 436-442
40. Weiss D.J., Evanson O.A., de Souza C., and Abrahamsen M.S. A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp. paratuberculosis. Am. J. Vet. Res. 66 (2005) 721-726
41. Weiss D.J., Evanson O.A., Deng M., and Abrahamsen M.S. Gene expression and antimicrobial activity of bovine macrophages in response to Mycobacterium avium subsp. paratuberculosis. Vet. Pathol. 41 (2004) 326-337
42. Weiss D.J., Souza C.D., Evanson O.A., Sanders M., and Rutherford M. Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. J. Leukoc. Biol. (2007)
43. Werling D., Hope J.C., Howard C.J., and Jungi T.W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology 111 (2004) 41-52
44. Werling D., Piercy J., and Coffey T.J. Expression of Toll-like receptors (TLR) by bovine antigen-presenting cells: Potential role in pathogen discrimination?. Vet. Immunol. Immunopathol., Innate Immun. Vacc. 112 (2006) 2-11
45. White S.N., Taylor K.H., Abbey C.A., Gill C.A., and Womack J.E. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 10364-10369
46. Yang Z., Nielsen R., Goldman N., and Pedersen A.M. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 155 (2000) 431-449