Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor

Biochemical Pharmacology

Volumn 68, Issue 11, 2004, Pages 2129-2142

  Patel, Oneel ^a   Dumesny, Chelsea ^a   Giraud, Andrew S ^a   Baldwin, Graham S ^a   Shulkes, Arthur ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Amidation; Bombesin; Glycine extended GRP; GRP; Migration; Proliferation; Signal transduction

Indexed keywords

BOMBESIN; GASTRIN; GASTRIN ANTAGONIST; GASTRIN RECEPTOR; GLYCINE; INOSITOL PHOSPHATE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C;

AMIDATION; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; LABELING INDEX; MITOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WOUND HEALING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BOMBESIN; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GASTRIN-RELEASING PEPTIDE; GLYCINE; HUMANS; INOSITOL PHOSPHATES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PROTEIN-TYROSINE KINASES; RECEPTORS, BOMBESIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 7444266737     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.08.009     Document Type: Article

References (52)

1. S.R. Preston, G.V. Miller, and J.N. Primrose Bombesin-like peptides and cancer Crit Rev Oncol Hematol 23 1996 225 238
2. F. Cuttitta, D.N. Carney, J. Mulshine, T.W. Moody, J. Fedorko, and A. Fischler Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer Nature 316 1985 823 826
3. J.C. Saurin, E. Nemoz-Gaillard, B. Sordat, J.C. Cuber, D.H. Coy, and J. Abello Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line Cancer Res 59 1999 962 967
4. G. Cassano, N. Resta, G. Gasparre, C. Lippe, and G. Guanti The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides Cancer Lett 172 2001 151 157
5. S. Radulovic, G. Miller, and A.V. Schally Inhibition of growth of HT-29 human colon cancer xenografts in nude mice by treatment with bombesin/gastrin releasing peptide antagonist (RC-3095) Cancer Res 51 1991 6006 6009
6. 2+ mobilization but not proliferation on human colon cancer cells Life Sci 53 1993 1859 1865
7. R.I. Feldman, S. Fried, E. Mann, J.M. Wu, and M. Liang Gastrin-releasing peptide receptor signaling resulting in growth inhibition Mol Pharmacol 49 1996 505 514
8. J.A. Jensen, R.E. Carroll, and R.V. Benya The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer Peptides 22 2001 689 699
9. R.E. Carroll, K.A. Matkowskyj, M.S. Tretiakova, J.F. Battey, and R.V. Benya Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer Cell Growth Differ 11 2000 385 393
10. O. Nagakawa, M. Ogasawara, J. Murata, H. Fuse, and I. Saiki Effect of prostatic neuropeptides on migration of prostate cancer cell lines Int J Urol 8 2001 65 70
11. J.C. Saurin, M. Fallavier, B. Sordat, J.C. Gevrey, J.A. Chayvialle, and J. Abello Bombesin stimulates invasion and migration of Isreco1 colon carcinoma cells in a rho-dependent manner Cancer Res 62 2002 4829 4835
12. J.C. Saurin, J.P. Rouault, J. Abello, F. Berger, L. Remy, and J.A. Chayvialle High gastrin releasing peptide receptor mRNA level is related to tumour dedifferentiation and lymphatic vessel invasion in human colon cancer Eur J Cancer 35 1999 125 132
13. H.S. Chave, A.C. Gough, K. Palmer, S.R. Preston, and J.N. Primrose Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa Br J Cancer 82 2000 124 130
14. S.S. Radulovic, S.R. Milovanovic, R.Z. Cai, and A.V. Schally The binding of bombesin and somatostatin and their analogs to human colon cancers Proc Soc Exp Biol Med 200 1992 394 401
15. H. Frucht, A.F. Gazdar, J.A. Park, H. Oie, and R.T. Jensen Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells Cancer Res 52 1992 1114 1122
16. R.E. Carroll, D. Ostrovskiy, S. Lee, A. Danilkovich, and R.V. Benya Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines Mol Pharmacol 58 2000 601 607
17. M.A. Nauck, I. Weber, I. Bach, S. Richter, C. Orskov, and J.J. Holst Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients Diabet Med 15 1998 937 945
18. C. Seva, C.J. Dickinson, and T. Yamada Growth-promoting effects of glycine-extended progastrin Science 265 1994 410 412
19. F. Hollande, A. Imdahl, T. Mantamadiotis, G.D. Ciccotosto, A. Shulkes, and G.S. Baldwin Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line Gastroenterology 113 1997 1576 1588
20. C. Oiry, J. Pannequin, N. Bernad, A.M. Artis, J.C. Galleyrand, and C. Devin A synthetic glycine-extended bombesin analogue interacts with the GRP/bombesin receptor Eur J Pharmacol 403 2000 17 25
21. N. Douziech, E. Calvo, J. Laine, and J. Morisset Activation of MAP kinases in growth responsive pancreatic cancer cells Cell Signal 11 1999 591 602
22. T.R. Sharif, W. Luo, and M. Sharif Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway Mol Cell Endocrinol 130 1997 119 130
23. K. Kiehne, K.H. Herzig, and U.R. Folsch Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J Pancreatology 2 2002 46 53
24. X. Qu, D. Xiao, and H.C. Weber Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells FEBS Lett 527 2002 109 113
25. V. Gabarra-Niecko, M.D. Schaller, and J.M. Dunty FAK regulates biological processes important for the pathogenesis of cancer Cancer Metastasis Rev 22 2003 359 374
26. J. Leyton, L.J. Garcia-Marin, J.A. Tapia, R.T. Jensen, and T.W. Moody Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells Cancer Lett 162 2001 87 95
27. M.D. Duncan, J.W. Harmon, and L.K. Duncan Actin disruption inhibits bombesin stimulation of focal adhesion kinase (pp125FAK) in prostate carcinoma J Surg Res 63 1996 359 363
28. K.A. Matkowskyj, K. Keller, S. Glover, L. Kornberg, R. Tran-Son-Tay, and R.V. Benya Expression of grp and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407 J Histochem Cytochem 51 2003 1041 1048
29. F. Chang, J.T. Lee, P.M. Navolanic, L.S. Steelman, J.G. Shelton, and W.L. Blalock Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy Leukemia 17 2003 590 603
30. J.T. Price, T. Tiganis, A. Agarwal, D. Djakiew, and E.W. Thompson Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism Cancer Res 59 1999 5475 5478
31. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
32. F. Hollande, D.J. Lee, A. Choquet, S. Roche, and G.S. Baldwin Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells J Cell Sci 116 2003 1187 1197
33. K. Hara, K. Yonezawa, H. Sakaue, A. Ando, K. Kotani, and T. Kitamura 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells Proc Natl Acad Sci USA 91 1994 7415 7419
34. A. Giraud, L. Salamonsen, J. Whitley, and A. Shulkes A peptide related to gastrin releasing peptide is synthesised and secreted by the ovine endometrium in early pregnancy Endocrinology 135 1994 2806 2809
35. F. Hollande, A. Choquet, E.M. Blanc, D.J. Lee, J.P. Bali, and G.S. Baldwin Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric epithelial cells J Biol Chem 276 2001 40402 40410
36. L.H. Wang, D.H. Coy, J.E. Taylor, N.Y. Jiang, J.P. Moreau, and S.C. Huang des-Met carboxyl-terminally modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists J Biol Chem 265 1990 15695 15703
37. S.A. Mantey, H.C. Weber, E. Sainz, M. Akeson, R.R. Ryan, and T.K. Pradhan Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors J Biol Chem 272 1997 26062 26071
38. C. Santiskulvong, J. Sinnett-Smith, and E. Rozengurt EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin Am J Physiol Cell Physiol 281 2001 C886 C898
39. T. Tsuda, T. Kusui, W. Hou, R.V. Benya, M.A. Akeson, and G.S. Kroog Effect of gastrin-releasing peptide receptor number on receptor affinity, coupling, degradation, and modulation Mol Pharmacol 51 1997 721 732
40. T.E. Solomon, G. Varga, N. Zeng, S.V. Wu, J.H. Walsh, and J.R. Reeve Jr. Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes Am J Physiol Gastrointest Liver Physiol 280 2001 G88 G94
41. J.F. Rehfeld, and W.W. van Solinge The tumor biology of gastrin and cholecystokinin Adv Cancer Res 63 1994 295 347
42. H.K. Yang, F.M. Scott, J.B. Trepel, J.F. Battey, B.E. Johnson, and M.J. Kelley Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines Lung Cancer 21 1998 165 175
43. A. Chaudhry, J.A. Carrasquillo, I.L. Avis, N. Shuke, J.C. Reynolds, and R. Bartholomew Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer Clin Cancer Res 5 1999 3385 3393
44. J.J. Holst, M. Hansen, E. Bork, and T.W. Schwartz Elevated plasma concentrations of C-flanking gastrin-releasing peptide in small-cell lung cancer J Clin Oncol 7 1989 1831 1838
45. A.J. Vangsted, and T.W. Schwartz Production of gastrin-releasing peptide-(18-27) and a stable fragment of its precursor in small cell lung carcinoma cells J Clin Endocrinol Metab 70 1990 1586 1593
46. T. Seufferlein, D.J. Withers, and E. Rozengurt Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin J Biol Chem 271 1996 21471 21477
47. S.W. Koh, J. Leyton, and T.W. Moody Bombesin activates MAP kinase in non-small cell lung cancer cells Peptides 20 1999 121 126
48. E.P. Salazar, I. Hunger-Glaser, and E. Rozengurt Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells J Cell Physiol 194 2003 314 324
49. H.R. Reiske, S.C. Kao, L.A. Cary, J.L. Guan, J.F. Lai, and H.C. Chen Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration J Biol Chem 274 1999 12361 12366
50. D. Ilic, C.H. Damsky, and T. Yamamoto Focal adhesion kinase: at the crossroads of signal transduction J Cell Sci 110 1997 401 407
51. L.A. Cary, J.F. Chang, and J.L. Guan Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn J Cell Sci 109 1996 1787 1794
52. J.H. Qi, and L. Claesson-Welsh VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase Exp Cell Res 263 2001 173 182