A novel therapy for acute hepatitis utilizing dehydroepiandrosterone in the murine model of hepatitis

Biochemical Pharmacology

Volumn 68, Issue 11, 2004, Pages 2283-2289

  Yoneda, Masato ^a   Wada, Koichiro ^b   Katayama, Kazufumi ^b   Nakajima, Noriko ^c   Iwasaki, Tomoyuki ^a   Osawa, Emi ^a   Mukasa, Koji ^a   Yamada, Yasuhiko ^d   Blumberg, Richard S ^e   Sekihara, Hisahiko ^a   Nakajima, Atsushi ^a,e  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c Department of Pathology   (Japan)

^d INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Apoptosis; Dehydroepiandrosterone; Hepatitis; Inflammatory mediators; Necrosis; T cell

Indexed keywords

ALANINE AMINOTRANSFERASE; CONCANAVALIN A; DNA FRAGMENT; GALACTOSAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PRASTERONE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEPATITIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATOMA CELL; LIVER; MEDIATOR RELEASE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION;

ANIMALS; APOPTOSIS; CONCANAVALIN A; DEHYDROEPIANDROSTERONE; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; HEPATITIS, TOXIC; HEPATOCYTES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C;

EID: 7444237578     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.07.044     Document Type: Article

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