Case 1-2010: A 75-year-old man with hypertension, hyperglycemia, and edema

New England Journal of Medicine

Volumn 362, Issue 2, 2010, Pages 156-

  McMahon, Graham T ^a,c   Blake, Michael A ^b,c   Wu, Chin Lee ^b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLUTETHIMIDE; ANTIHYPERTENSIVE AGENT; BICALUTAMIDE; CARBOPLATIN; CONTRAST MEDIUM; ETOPOSIDE; INSULIN; KETOCONAZOLE; LEUPRORELIN; MEDRONATE TECHNETIUM TC 99M; METYRAPONE; MIFEPRISTONE; MITOTANE; PREDNISONE; SOMATOSTATIN; SPIRONOLACTONE; CORTICOTROPIN; HYDROCORTISONE;

ADRENAL TUMOR; ADRENALECTOMY; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CLINICAL FEATURE; COLON CARCINOMA; COMPUTER ASSISTED TOMOGRAPHY; CUSHING SYNDROME; DIFFERENTIAL DIAGNOSIS; DIPLOPIA; DISEASE COURSE; DRUG WITHDRAWAL; ECTOPIC CORTICOTROPIN PRODUCTION; ELECTROCARDIOGRAM; EPISTAXIS; FAMILY HISTORY; FOLLOW UP; FOOT EDEMA; GLUCOSE INTOLERANCE; GYNECOMASTIA; HEADACHE; HEMANGIOMA; HEMATURIA; HISTOPATHOLOGY; HUMAN; HYPERCORTISOLISM; HYPERGLYCEMIA; HYPERTENSION; HYPOKALEMIA; LABORATORY TEST; LEG PAIN; LEG SWELLING; MALE; METASTASIS; METASTATIC NEUROENDOCRINE CARCINOMA; MULTIPLE CYCLE TREATMENT; NEUROENDOCRINE TUMOR; OPHTHALMOSCOPY; PRIORITY JOURNAL; PROSTATE CANCER; SMALL CELL CARCINOMA; SYSTOLIC HEART MURMUR; THYROID CARCINOMA; URINALYSIS; WEIGHT GAIN; WHEEZING; BONE TUMOR; CLINICAL OBSERVATION; CLINICAL STUDY; DIAGNOSIS; EDEMA; FATALITY; LIVER TUMOR; LUNG TUMOR; METABOLISM; PARANEOPLASTIC SYNDROME; PATHOLOGY; PROSTATE TUMOR;

ADRENOCORTICOTROPIC HORMONE; AGED; BONE NEOPLASMS; CARCINOMA, SMALL CELL; CUSHING SYNDROME; DIAGNOSIS, DIFFERENTIAL; EDEMA; FATAL OUTCOME; HUMANS; HYDROCORTISONE; HYPERGLYCEMIA; HYPERTENSION; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; PARANEOPLASTIC SYNDROMES; PROSTATIC NEOPLASMS;

EID: 74249098402     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcpc0905546     Document Type: Article

References (31)

1. Chiong JR, Aronow WS, Khan IA, et al. Secondary hypertension: current diagnosis and treatment. Int J Cardiol 2008;124:6-21.
2. DeLellis RA, Xia L. Paraneoplastic endocrine syndromes: a review. Endocr Pathol 2003;14:303-17.
3. Nieman LK, Ilias I. Evaluation and treatment of Cushing's syndrome. Am J Med 2005;118:1340-6.
4. Buchfelder M, Nistor R, Fahlbusch R, Huk WJ. The accuracy of CT and MR evaluation of the sella turcica for detection of adrenocorticotropic hormone-secreting adenomas in Cushing disease. AJNR Am J Neuroradiol 1993;14:1183-90.
5. Schteingart DE. Adjuvant mitotane therapy of adrenal cancer - use and controversy. N Engl J Med 2007;356:2415-8.
6. Blake MA, Jhaveri KS, Sweeney AT, et al. State of the art in adrenal imaging. Curr Probl Diagn Radiol 2002;31:67-78.
7. Brown W. A case of pluriglandular syndrome. Lancet 1928;2:1022-3.
8. Liddle GW, Nicholson WE, Island DP, Orth DN, Abe K, Lowder SC. Clinical and laboratory studies of ectopic humoral syndromes. Recent Prog Horm Res 1969;25:283-314.
9. Isidori AM, Lenzi A. Ectopic ACTH syndrome. Arq Bras Endocrinol Metabol 2007;51:1217-25.
10. Ray D, Tomar N, Gupta N, Goswami R. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians. Int J Immunogenet 2006;33:237-40.
11. Anthoney DA, Dunlop DJ, Connell JM, Kaye SB. Colonic adenocarcinoma associated ectopic ACTH secretion: a case history. Eur J Cancer 1995;31A:2109-12.
12. Stambaugh JE Jr, Redfield ES. Ectopic production of ACTH by a primary adenocarcinoma of the colon. J Med Soc N J 1978;75:925-6.
13. Mure A, Gicquel C, Abdelmoumene N, et al. Cushing's syndrome in medullary thyroid carcinoma. J Endocrinol Invest 1995;18:180-5.
14. Sciarra A, Cardi A, Dattilo C, Mariotti G, Di Monaco F, Di Silverio F. New perspective in the management of neuroendocrine differentiation in prostate adenocarcinoma. Int J Clin Pract 2006;60:462-70.
15. Hansson J, Abrahamsson PA. Neuroendocrine differentiation in prostatic carcinoma. Scand J Urol Nephrol Suppl 2003;212:28-36.
16. Alwani RA, Neggers SJ, van der Klift M, et al. Cushing's syndrome due to ectopic ACTH production by (neuroendocrine) prostate carcinoma. Pituitary 2009;12:280-3.
17. Suzuki N, Kobayashi Y, Yasuhara K, et al. A case of prostatic carcinoma with ectopic ACTH syndrome. Nippon Hinyokika Gakkai Zasshi 1993;84:2027-30. (In Japanese.)
18. Kataoka K, Akasaka Y, Nakajima K, et al. Cushing syndrome associated with prostatic tumor adrenocorticotropic hormone (ACTH) expression after maximal androgen blockade therapy. Int J Urol 2007;14:436-9.
19. Stathem BN, Pardoe TH, Mir MA. Response of ectopic prostatic ACTH production to metyrapone. Postgrad Med J 1981;57:467-8.
20. Wenk RE, Bhagavan BS, Levy R, Miller D, Weisburger W. Ectopic ACTH, prostatic oat cell carcinoma, and marked hypernatremia. Cancer 1977;40:773-8.
21. Nimalasena S, Freeman A, Harland S. Paraneoplastic Cushing's syndrome in prostate cancer: a difficult management problem. BJU Int 2008;101:424-7.
22. Rickman T, Garmany R, Doherty T, Benson D, Okusa MD. Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. Am J Kidney Dis 2001;37:838-46.
23. Wang W, Epstein JI. Small cell carcinoma of the prostate: a morphologic and immunohistochemical study of 95 cases. Am J Surg Pathol 2008;32:65-71.
24. Yao JL, Madeb R, Bourne P, et al. Small cell carcinoma of the prostate: an immunohistochemical study. Am J Surg Pathol 2006;30:705-12.
25. Oesterling JE, Hauzeur CG, Farrow GM. Small cell anaplastic carcinoma of the prostate: a clinical, pathological and immunohistological study of 27 patients. J Urol 1992;147:804-7.
26. Têtu B, Ro JY, Ayala AG, Johnson DE, Logothetis CJ, Ordonez NG. Small cell carcinoma of the prostate. I. A clinicopathologic study of 20 cases. Cancer 1987;59:1803-9.
27. Shalet S, Mukherjee A. Pharmacological treatment of hypercortisolism. Curr Opin Endocrinol Diabetes Obes 2008;15:234-8.
28. Sonino N. The use of ketoconazole as an inhibitor of steroid production. N Engl J Med 1987;317:812-8.
29. Nieman LK. Medical therapy of Cushing's disease. Pituitary 2002;5:77-82.
30. Terzolo M, Angeli A, Fassnacht M, et al. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 2007;356:2372-80.
31. de Bruin C, Feelders RA, Lamberts SW, Hofland LJ. Somatostatin and dopamine receptors as targets for medical treatment of Cushing's syndrome. Rev Endocr Metab Disord 2009;10:91-102.