DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3′)TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives

Chemico-Biological Interactions

Volumn 183, Issue 3, 2010, Pages 349-356

  Liu, Yanan ^a   Chen, Tianfeng ^a,b   Wong, Yum Shing ^b   Mei, Wen Jie ^a,c   Huang, Xiao Mei ^c   Yang, Fang ^a   Liu, Jie ^a   Zheng, Wen Jie ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; DNA binding; Mitochondria; Photocleavage; Ruthenium porphyrin complex

Indexed keywords

5 (3' PYRIDYL 10,15,20 TRIPHENYLPORPHYRIN) RUTHENIUM 1,10 PHENANTHROLINE; 5 (3' PYRIDYL 10,15,20 TRIPHENYLPORPHYRIN) RUTHENIUM 1,10 PHENANTHROLINE COPPER; 5 (3' PYRIDYL 10,15,20 TRIPHENYLPORPHYRIN) RUTHENIUM 1,10 PHENANTHROLINE NICKEL; DOUBLE STRANDED DNA; PROTEIN BCL 2; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER PREVENTION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA CELL; METAL BINDING; MITOCHONDRIAL MEMBRANE POTENTIAL;

APOPTOSIS; CELL LINE, TUMOR; DNA; DNA CLEAVAGE; DRUG SCREENING ASSAYS, ANTITUMOR; G0 PHASE; G1 PHASE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METALLOPORPHYRINS; PHOTOLYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPECTROPHOTOMETRY, ULTRAVIOLET; VISCOSITY;

EID: 74149093581     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.11.026     Document Type: Article

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