Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells contribute to hearing loss in neuraminidase 1-deficient mice

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1802, Issue 2, 2010, Pages 259-268

  Wu, Xudong ^a,b   Steigelman, Katherine A ^a,b   Bonten, Erik ^a   Hu, Huimin ^a   He, Wenxuan ^c   Ren, Tianying ^c   Zuo, Jian ^a   d'Azzo, Alessandra ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cochlea; Endolymphatic potential; Hearing loss; Lysosomes; Sialidosis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; POTASSIUM CHANNEL KCNQ1; SIALIDASE; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CELL VACUOLE; CERUMEN; COCHLEA; CONDUCTION DEAFNESS; CONTROLLED STUDY; CORTI ORGAN; ENDOLYMPH; EVOKED BRAIN STEM AUDITORY RESPONSE; EXOCYTOSIS; EXTERNAL AUDITORY CANAL; GALACTOSIALIDOSIS; HAIR CELL; HEARING LOSS; LYSOSOME STORAGE DISEASE; MOUSE; NONHUMAN; OTITIS MEDIA; PERCEPTION DEAFNESS; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIALYLATION; SPIRAL GANGLION; STRIA VASCULARIS; WILD TYPE;

ANIMALS; COCHLEA; DISEASE MODELS, ANIMAL; EAR, MIDDLE; HEARING LOSS; LYSOSOMAL STORAGE DISEASES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; NEURAMINIDASE; VACUOLES;

MUS;

EID: 74149087076     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2009.10.008     Document Type: Article

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