Influence of age on clock gene expression in peripheral blood cells of healthy women

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 65, Issue 1, 2010, Pages 9-13

  Ando, Hitoshi ^a   Ushijima, Kentarou ^a   Kumazaki, Masafumi ^b   Takamura, Toshinari ^b   Yokota, Noritsugu ^c   Saito, Tetsuo ^c   Irie, Shin ^d   Kaneko, Shuichi ^b   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c Moka Hospital   (Japan)

^d LTA Medical Corporation   (Japan)

Author keywords

Aging; Biological clock; Circadian rhythm; Shift work

Indexed keywords

ARNTL PROTEIN, HUMAN; CIRCADIAN RHYTHM SIGNALING PROTEIN; MESSENGER RNA; PER1 PROTEIN, HUMAN; PER3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK;

ADULT; AGED; AGING; ARTICLE; BIOLOGICAL RHYTHM; BLOOD; BLOOD CELL; BODY MASS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MIDDLE AGED; OBESITY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS; REFERENCE VALUE; RETROSPECTIVE STUDY;

ADULT; AGED; AGING; ARNTL TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; BLOOD CELLS; BODY MASS INDEX; CLOCK PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MIDDLE AGED; OBESITY; PERIOD CIRCADIAN PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; REFERENCE VALUES; RETROSPECTIVE STUDIES; RNA, MESSENGER; YOUNG ADULT;

EID: 74049144876     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glp160     Document Type: Article

References (37)

1. Lowrey PL, Takahashi JS. Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet. 2004;5:407-441.
2. Reppert SM, Weaver DR. Coordination of circadian timing in mam-mals. Nature. 2002;418:935-941.
3. Yoo SH, Yamazaki S, Lowrey PL, et al. PERIOD2: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 2004;101:5339-5346. (Pubitemid 38481161)
4. Yamamoto T, Nakahata Y, Soma H, Akashi M, Mamine T, Takumi T Transcriptional oscillation of canonical clock genes in mouse periph-eral tissues. BMC Mol Biol. 2004;5:18. (Pubitemid 41418179)
5. Kusanagi H, Mishima K, Satoh K, Echizenya M, Katoh T, Shimizu T Similar profi les in human period1 gene expression in peripheral mononu-clear and polymorphonuclear cells. Neurosci Lett. 2004;365:124-127. (Pubitemid 38881638)
6. Ando H, Takamura T, Matsuzawa-Nagata N, et al. Clock gene expres-sion in peripheral leucocytes of patients with type 2 diabetes. Diabeto-logia. 2009;52:329-335.
7. Gekakis N, Staknis D, Nguyen HB, et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 1998;280:1564-1569. (Pubitemid 28277694)
8. Bunger MK, Wilsbacher LD, Moran SM, et al. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 2000;103:1009-1017.
9. Kume K, Zylka MJ, Sriram S, et al. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999;98:193-205. (Pubitemid 29344907)
10. Okamura H, Miyake S, Sumi Y, et al. Photic induction of mPer1 and mPer2 in cry-defi cient mice lacking a biological clock. Science 1999;286:2531-2534. (Pubitemid 30026347)
11. Vitaterna MH, Selby CP, Todo T, et al. Differential regulation of mam-malian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci USA. 1999;96:12114-12119. (Pubitemid 29502867)
12. Turek FW, Joshu C, Kohsaka A, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005 ; 308: 1043-1045. (Pubitemid 40664419)
13. Woon PY, Kaisaki PJ, Braganca J, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci USA. 2007 ; 104:14412-14417. (Pubitemid 350003275)
14. Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008;32:658-662. (Pubitemid 351536018)
15. Sookoian S, Gemma C, Gianotti TF, Burgueno A, Castano G, Pirola CJ. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr. 2008;87:1606-1615. (Pubitemid 351872621)
16. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage re-sponse in vivo. Cell. 2002;111:41-50.
17. Lin YC, Hsiao TJ, Chen PC. Persistent rotating shift-work exposure accelerates development of metabolic syndrome among middle-aged female employees: a five-year follow-up. Chronobiol Int. 2009;26: 740-755.
18. Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 peopletion based study of 27,485 people. Occup Environ Med. 2001;58: 747-752. (Pubitemid 33010493)
19. Suwazono Y, Dochi M, Sakata K, et al. A longitudinal study on the effect of shift work on weight gain in male Japanese workers. Obesity (Silver Spring). 2008;16:1887-1893.
20. Hansen J. Risk of breast cancer after night-and shift work: current evidence and ongoing studies in Denmark. Cancer Causes Control 2006;17:531-537.
21. Hofman MA. The human circadian clock and aging. Chronobiol Int 2000;17:245-259.
22. Kunieda T, Minamino T, Katsuno T, et al. Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res 2006;98:532-539. (Pubitemid 43755312)
23. TouitouY, Haus E. Alterations with aging of the endocrine and neu-roendocrine circadian system in humans. Chronobiol Int. 2000;17: 369-390.
24. Balsalobre A, Brown SA, Marcacci L, et al. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science. 2000; 289:2344-2347.
25. Kunieda T, Minamino T, Miura K, et al. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 2008; 102:607-614. (Pubitemid 351416757)
26. Weinert D. Age-dependent changes of the circadian system. Chronobiol Int. 2000;17:261-283. (Pubitemid 30366506)
27. Ando H, Yanagihara H, Hayashi Y, et al. Rhythmic messenger ribo-nucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology. 2005;146:5631-5636. (Pubitemid 41653080)
28. Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, Fukada Y. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J Biol Chem 2002;277:44244-44251. (Pubitemid 36157857)
29. Cavadini G, Petrzilka S, Kohler P, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated tran-scription. Proc Natl Acad Sci USA. 2007;104:12843-12848. (Pubitemid 47255242)
30. Nonaka H, Emoto N, Ikeda K, et al. Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells. Circulation. 2001;104:1746-1748. (Pubitemid 32963335)
31. Mutch DM, Clement K. Unraveling the genetics of human obesity. PLoS Genet. 2006;2:e188.
32. James FO, Boivin DB, Charbonneau S, Belanger V, Cermakian N. Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles. Chronobiol Int 2007;24:1009-1034.
33. Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. Sleep. 2008;31:608-617.
34. Takimoto M, Hamada A, Tomoda A, et al. Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circa-dian rhythm sleep disorder. Am J Physiol Regul Integr Comp Physiol 2005;289:R1273-R1279.
35. Burioka N, Koyanagi S, Endo M, et al. Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J. 2008; 32:105-112.
36. Ando H, Ushijima K, Kumazaki M, et al. Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. Chronobiol Int. In press
37. Gomez-Abellan P, Hernandez-Morante JJ, Lujan JA, Madrid JA, Garaulet M. Clock genes are implicated in the human metabolic syndrome. Int J Obes (Lond). 2008;32:121-128.