Effects of nonsteroidal anti-inflammatory drugs on the expression and function of P-Glycoprotein/MDR1 in Caco-2 cells

Drug and Chemical Toxicology

Volumn 32, Issue 4, 2009, Pages 332-337

  Takara, Kohji ^a   Hayashi, Ryuhei ^b   Kokufu, Misato ^b   Yamamoto, Kazuhiro ^b   Kitada, Noriaki ^b   Ohnishi, Noriaki ^a   Yokoyama, Teruyoshi ^a  

^a HIMEJI DOKKYO UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Caco 2 cell; Intestinal absorption; MDR1; Nonsteroidal anti inflammatory drug; P glycoprotein; Upregulation

Indexed keywords

ACETYLSALICYLIC ACID; DICLOFENAC; EPIRIZOLE; FENBUFEN; FLUFENAMIC ACID; FLURBIPROFEN; GLYCOPROTEIN P; IBUPROFEN; INDOMETACIN; KETOPROFEN; MEFENAMIC ACID; MELOXICAM; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; RHODAMINE 123; SALICYLAMIDE; SULINDAC; ANTINEOPLASTIC AGENT; CYTOCHROME P450 3A; MULTIDRUG RESISTANCE PROTEIN; SMALL INTERFERING RNA; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; DOSE RESPONSE; DRUG INTERACTION; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; IC 50; METABOLISM; METHODOLOGY; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOMETHACIN; INHIBITORY CONCENTRATION 50; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RNA, MESSENGER; RNA, SMALL INTERFERING; THIAZINES; THIAZOLES;

EID: 74049127972     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540903130658     Document Type: Article

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