Ultrasound-promoted copper-catalyzed azide - alkyne cycloaddition

Journal of Combinatorial Chemistry

Volumn 12, Issue 1, 2010, Pages 13-15

  Cravotto, Giancarlo ^a   Fokin, Valery V ^b   Garella, Davide ^a   Binello, Arianna ^a   Boffa, Luisa ^a   Barge, Alessandro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; AZIDE; COPPER;

ARTICLE; CATALYSIS; CHEMISTRY; CYCLIZATION; ULTRASOUND;

ALKYNES; AZIDES; CATALYSIS; COPPER; CYCLIZATION; ULTRASONICS;

EID: 74049123804     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc900150d     Document Type: Article

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38. 2O 8:2 or in DMF (10 mL). The azido compound (1 mmol, if not otherwise stated) and the acetylenic derivative (1.05 mmol, 5.0 mmol for entries 27-34) were added, and the mixture was heated and/or irradiated with MW or MW/US as indicated in the tables. The reaction outcome was monitored by TLC or GC/MS until complete conversion of the starting material was observed; then the copper was filtered off on paper filter. After evaporation of the solvent under vacuum, the crude product was purified by flash-chromatography. The residual, copper had a minimal loss of weight (5-7%) and can be directly reused maintaining almost the same catalytic activity for a couple of times.
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