Nitric oxide (NO), citrullineNO cycle enzymes, glutamine synthetase, and oxidative status in kainic acid-mediated excitotoxicity in rat brain

Drug and Chemical Toxicology

Volumn 32, Issue 4, 2009, Pages 326-331

  Swamy, Mummedy ^a   Sirajudeen, Kuttulebbai N S ^a   Chandran, Govindasamy ^a  

^a SCHOOL OF HEALTH SCIENCES   (Malaysia)

Author keywords

Citrulline nitric oxide cycle; Excitotoxicity; Glutamine synthetase; Nitric oxide; Thiobarbituric acid reactive substances; Total antioxidant status

Indexed keywords

ARGINASE; ARGININE; ARGININOSUCCINATE LYASE; ARGININOSUCCINATE SYNTHASE; CITRULLINE; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; KAINIC ACID; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ASPARTIC ACID; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; EXCITOTOXICITY; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; ANIMAL; BRAIN; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MUSCLE RELAXATION; NERVE CELL; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM;

RATTUS;

ANIMALS; ASPARTIC ACID; BRAIN; CITRULLINE; ENDOTHELIUM, VASCULAR; GLUTAMATE-AMMONIA LIGASE; KAINIC ACID; MUSCLE RELAXATION; NEURONS; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 74049095570     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540903130641     Document Type: Article

References (45)

1. Alabadi, J., Thibault, J. L., Pinard, E., Seylaz, J., Lasbennes, F., (1999). 7-nitroindazole, a selective inhibitor of nNOS, increases hippocampal extracellular glutamate concentration in status epilepticus induced by kainic acid in rats. Brain Res 839:305-312.
2. Aldridge, C. R., Collard, K. J. (1996). The characteristics of arginine transport by rat cerebellar and cortical synaptosomes. Neurochem Res 21:1539-1546.
3. Barger, S. W., Goodwin, M. E., Porter, M. M., Beggs M. L. (2007). Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. J Neurochem 101: 1205-1213.
4. Bommarius, A. S., Makryaleas, K., Drauz, K. (1991). An enzymatic route to L-ornithine from L-arginine-activation and stabilization studies on L-arginase. Biomed Biochim Acta 50:S249-S255.
5. 2+ rises and consequent oxygen radical production. J Neurosci 18:7727-7738.
6. 2+ overload and ROS generation in spinal motor neurons in vitro. J Neurosci 20:240-250.
7. Chatterjee, P. K., Cuzzocrea, S., Brown, P. A., Zacharowiski, K., Stewart, K. N., Motafilipe, H., et al. (2000) Tempol, a membrane- permeable radical scavenger, reduces oxidant stress- mediated renal dysfunction and injury in the rat. Kidney Int 58:658-673.
8. Coyle, J. T., Puttfarcken, P. (1993). Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695.
9. Dawson, R., Beal, M. F., Bondy, S. C., DiMonte, D. A., Isom, G. E. (1995). Excitotoxins, aging, and environmental neurotoxins: implications for understanding human neurodegenerative diseases. Toxicol Appl Pharm 134:1-17.
10. Doble, A. (1999). The role of excitotoxicity in neurodegenerative diseases implications for therapy. Pharmacol Ther 81:163-221.
11. Frantseva, M. K., Perezvelzquez, J. L., Tsoraklidis, G., Mendonca, A. J., Adamchik, Y., Mills, L. R., et al. (2000). Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neuroscience 97:431-435.
12. Girard, G., Giguere, J.-F., Butterworth, R. F. (1993). Region selective reductions in activities of glutamine synthetase in rat brain following portacaval anastomosis. Metab Brain Dis 8:207-215.
13. Guix, F. X., Uribesalgo, M., Coma, M., Munoz, F. J. (2005). The physiology and patophysiology of nitric oxide in the brain. Prog Neurobiol 76:126-152.
14. Herzfeld, A., Raper, S. M. (1976). The heterogeneity of arginase in rat tissues. Biochem J 153:469-478.
15. Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S., Masaki, T. (1997). Cloning and characterization of a brain-specific amino acid transporter. J Biol Chem 272:8717-8722.
16. Kawahara, K., Gotoh, T., Oyadomari, S., Kajizono, M., Kuniyasu, A., Ohsawa, K., et al. (2001). Co-induction of argininosuccinate synthetase, cationic amino acid transporter- 2, and nitric oxide synthase in activated murine microglial cells. Mol Brain Res 90:165-173.
17. Koracevic, D., Koracevic, G., Djordjevic, V., Andrejevic, S., Cosic, V. (2000). Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54:356-361.
18. Kosenko, E., Llansola, M., Montoliu, C., Monfort, P., Rodrigo, R., Hernandez-Viadel, M., et al. (2003). Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int 43:493-499.
19. Lapouble, E., Montecot, C., Sevestre, A., Pichon, J. (2002). Phosphinothricin induces epileptic activity via nitric oxide production through NMDA-receptor activation in adult mice. Brain Res 957:46-52.
20. Levin, B. (1971). In: Bodensky, O., Latner, A. L. (Eds.), Hereditary metabolic disorders of the urea cycle. Avances in Clinical Chemistry, Vol 14 (p 66).New York:Academic Press.
21. Milatovic, D., Gupta, R. C., Dettbarn, W. D. (2002). Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. Brain Res 957:330-337.
22. Nakaki, T., Mishima, A., Suzuki, E., Shintani, F., Fujii, T. (2000). Glufosinate ammonium stimulates nitric oxide production through N-methyl-D-aspartate receptors in rat cerebellum. Neurosci Lett 290:209-212.
23. Olney, J. W., Rhee, V., Ho, O. L. (1974). Kainic acid: a powerful neurotoxic analogue of glutamate. Brain Res 77:507-512.
24. Penix, L. P., Davis, W., Subramaniam, S. (1994). Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. Epilepsy Res 18:177-184.
25. Prast, H., Philippu, A. (2001). Nitric oxide as modulator of neuronal function. Prog Neurobiol 64:51-68.
26. Radenovic, L., Selakovic, V. (2005). Differential effects of NMDA and AMPA/kainate receptor antagonists on nitric oxide production in rat brain following intrahippocampal injection. Brain Res Bull 67:133-141.
27. Rodrigo, R., Felipo, V. (2007). Control of brain glutamine synthesis by NMDA receptors. Front Biosci 12:883-890.
28. Rose, C., Felipo, V. (2005). Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis 20:275-283.
29. Rothman, S. M., Olney, J. W. (1986). Glutamate and the pathophysiologyof hypoxic-ischemic brain damage. Ann Neurol 19:105-111.
30. Rowe, W. B., Ronzio, R. A., Wellner, V. P, Meister, A. (1970).Glutamine synthetase (sheep brain). In: Tabor, H., Tabor, C. W. (Eds.), Methods in Enzymology, Vol XVII, Part A (pp 900-910). New York: Academic Press.
31. Rundfeldt, C., Koch, R., Richter, A., Mevissen, M., Gerecke, U., Loscher, W. (1995). Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats. Eur J Pharmacol 274:73-81
32. Sadasivudu, B., Lajtha, A. (1970). Metabolism of amino acids in incubated slices of mouse brain. J Neurochem 17:1299-1311.
33. Sadasivudu, B., Nasreen, Z., Swamy, M. (1985). Functional significance of the activities of glutaminase and ornithine-ω- aminotransferase in rat brain. Neurochem Int 7:449-454. (Pubitemid 15028451)
34. Schmidlin, A., Wiesinger, H. (1994). Transport of L-arginine in cultured glial cells. Glia 11:262-268.
35. Sperk, G. (1994). Kainic acid seizures in the rat. Prog Neurobiol 42:1-32.
36. Swamy M, Adlin, Z. Z, Chandran, G., Sirajudeen, K. N. S., Nadiger, H. A. (2005). Effect of acute ammonia toxicity on nitric oxide (NO), citrulline-NO cycle enzymes, arginase, and related metabolites in different regions of rat brain. Neurosci Res 53:116-122.
37. Swamy, M., Sirajudeen, K. N. S., Chandran G. (2007). Nitric oxide, lipid peroxidation, and total antioxidant status in different regions of rat brain in kainic acid-mediated excitotoxicity. MJMS 14(Suppl 1):169.
38. Szatkowski, M., Attwell, D. (1994). Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci 17:359-365.
39. Takahashi, M., Billups, B., Rossi, D., Sarantis, M., Hamann, M., Attwell, D. (1997). The role of glutamate transporters in glutamate homeostasis in the brain. J Exp Biol 200:401-409.
40. Van der berg, C. J., Garfinkel, D. (1971). A stimulation study of brain compartments, metabolism of glutamate, and related substances in mouse brain. Biochem J 123:211-218.
41. Wang, Q., Yu, S., Simonyi, A., Sun, G. Y., Sun, A. Y. (2005). Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol 31:3-16.
42. Westergaard, N., Beart, P. M., Schousboe, A. (1993). Transport of L-[3H] arginine in cultured neurons: characteristics and inhibition by nitric oxide synthase inhibitors. J Neurochem 61:364-367.
43. Wiesinger, H. (2001). Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 64:365-391.
44. Yui, Y., Hattori, R., Kosuga, K., Eizawa, H., Hiki, K., Ohkawa, S., et al. (1991). Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. J Biol Chem 266:3369-3371.
45. Zhang, W.Y., Gotoh, T., Oyadomari, S., Mori, M. (2000). Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high-output production of nitric oxide. Mol Brain Res 83:1-8.