Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum

Neuroscience Letters

Volumn 290, Issue 3, 2000, Pages 209-212

  Nakaki, Toshio ^a   Mishima, Akira ^a   Suzuki, Eiji ^b   Shintani, Futoshi ^c   Fujii, Tomoko ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebellum; Glufosinate; Kainate; Microdialysis; N methyl D aspartate; Nitric Oxide

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMIC ACID; KAINIC ACID; KAINIC ACID RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PHOSPHINOTHRICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TOXICITY; CEREBELLUM; CHEMICAL REACTION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; MALE; MEDIATOR RELEASE; MICRODIALYSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

AMINOBUTYRIC ACIDS; ANIMALS; CEREBELLUM; GLUTAMIC ACID; HERBICIDES; KAINIC ACID; MALE; N-METHYLASPARTATE; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED F344; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034283694     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01363-X     Document Type: Article

References (20)

1. Alford S., Grillner S. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 506:1990;297-302.
2. Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA. 86:1989;9030-9033.
3. Christopherson K.S., Hillier B.J., Lim W.A., Bredt D.S. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J. Biol. Chem. 274:1999;27467-27473.
4. Doyle M.P., Herman J.G., Dykstra R.L. Autocatalytic oxidation of hemoglobin induced by nitrite: activation and chemical inhibition. J. Free Radic. Biol. Med. 1:1985;145-153.
5. Ebert E., Leist K.H., Mayer D. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem. Toxicol. 28:1990;339-349.
6. 2+-dependent L-glutamate binding sites do not correspond to 2-amino-4-phosphonobutanoate-sensitive excitatory amino acid receptors. Br. J. Pharmacol. 86:1985;743-751.
7. Fujii T. Biochemical and pharmacological assessment of functional disorders induced by exposure to herbicides in the rat with special reference to gametocyte damage (in Japanese). Yasui I. Research Report on Coordination Board for a Scientific Approach Toward Globalization of Human Society in Harmony with the Earth: The Man-Earth System. 1993;286-288. A02-E00, the Japanese Ministry of Education, Science, Sports and Culture.
8. Fujii T., Hase C., Inazu N., Fujino Y. Transgeneration effects of glufosinate ammonium, a herbicide, in rats (in Japanese). Environ. Sci. 9:1996;88-90.
9. Fujii T., Ohta T., Horinaka M. Alterations in the response to kainic acid in rats exposed to glufosinate ammonium, a herbicide, during infantile period. Proc. Jpn. Acad. 72:1996;7-10.
10. Garthwaite J., Southam E., Anderton M. A kainate receptor linked to nitric oxide synthesis from arginine. J. Neurochem. 53:1989;1952-1954.
11. Hack R., Ebert E., Ehling G., Leist K.H. Glufosinate ammonium-some aspects of its mode of action in mammals. Food Chem. Toxicol. 32:1994;461-470.
12. Lehmann J., Schneider J., McPherson S., Murphy D.E., Bernard P., Tsai C., Bennett D.A., Pastor G., Steel D.J., Boehm C., Cheney D.L., Liebman J.M., Williams M., Wood P.L. CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo. J. Pharmacol. Exp. Ther. 240:1987;737-746.
13. Luo D., Knezevich S., Vincent S.R.,. N-methyl-D-aspartate-induced nitric oxide release: an in vivo microdialysis study. Neuroscience. 57:1993;897-900.
14. Michel P.P., Agid Y. Death of septal cholinergic neurons produced by chronic exposure to glutamate is prevented by the non-competitive NMDA receptor/channel antagonist. MK-801: role of nerve growth factor and nitric oxide, J. Neurosci. Res. 40:1995;764-775.
15. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, Orlando.
16. Shintani F., Kanba S., Nakaki T., Sato K., Yagi G., Kato R., Asai M. Measurement by in vivo brain microdialysis of nitric oxide release in the rat cerebellum. J. Psychiatr. Neurosci. 19:1994;217-221.
17. Smith T.S., Bennett J.P. Jr. Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions. Brain Res. 765:1997;183-188.
18. Southam E., East S.J., Garthwaite J. Excitatory amino acid receptors coupled to the nitric oxide/cyclic GMP pathway in rat cerebellum during development. J. Neurochem. 56:1991;2072-2081.
19. Watanabe T. Apoptosis induced by glufosinate ammonium in the neuroepithelium of developing mouse embryos in culture. Neurosci. Lett. 222:1997;17-20.
20. Yamada K., Nabeshima T. Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of conscious rats. J. Neurochem. 68:1997;1234-1243.