7-Nitroindazole, a selective inhibitor of nNOS, increases hippocampal extracellular glutamate concentration in status epilepticus induced by kainic acid in rats

Brain Research

Volumn 839, Issue 2, 1999, Pages 305-312

  Alabadí, José A ^a   Thibault, Jean Luc ^a   Pinard, Elisabeth ^a   Seylaz, Jacques ^a   Lasbennes, François ^a  

^a CNRS   (France)

Author keywords

7 Nitroindazole; Glutamate; Hippocampus; Kainic acid; Microdialysis; Nitric oxide

Indexed keywords

7 NITROINDAZOLE; ARGININE; CITRULLINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EPILEPTIC STATE; GLIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; MICRODIALYSIS; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARGININE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRULLINE; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXTRACELLULAR SPACE; GLUTAMIC ACID; HIPPOCAMPUS; INDAZOLES; KAINIC ACID; MALE; MICRODIALYSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR; STATUS EPILEPTICUS; SYNAPTIC TRANSMISSION;

EID: 0033612937     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01749-7     Document Type: Article

References (53)

1. Balcioglu A., Maher T.J. Determination of kainic acid-induced release of nitric oxide using a novel hemoglobin trapping technique with microdialysis. J. Neurochem. 61:1993;2311-2313.
2. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad and the ugly. Am. J. Physiol. 271:1996;C1424-C1437.
3. Chapman A.G., Meldrum B.S. Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice. Eur. J. Pharmacol. 166:1989;201-211.
4. Cholet N., Bonvento G., Seylaz J. Effect of neuronal NO synthase inhibition on the cerebral vasodilatory response to somatosensory stimulation. Brain Res. 708:1996;197-200.
5. Dawson V.L., Dawson T.M., London E.D., Bredt D.S. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6368-6371.
6. Dawson V.L., Kizushi V.M., Huang P.L., Snyder S.H., Dawson T.M. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16:1996;2479-2487.
7. East S.J., Garthwaite J. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci. Lett. 123:1991;17-19.
8. 1 hippocampal neurons and other central nervous system neurons. Neuroscience. 63:1994;679-689.
9. Erecinska M., Nelson D., Vanderkooi J.M. Effects of NO-generating compounds on synaptosomal energy metabolism. J. Neurochem. 65:1995;2699-2705.
10. Fariello R.G., Golden G.T., Smith G.G., Reyes P.F. Potentiation of kainic acid epileptogenicity and sparing from neuronal damage by an NMDA receptor antagonist. Epilepsy Res. 3:1989;206-213.
11. Ferkany J.W., Coyle J.T. Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids. J. Pharmacol. Exp. Ther. 225:1983;399-406.
12. Garthwaite J., Southam E., Anderton M. A kainate receptor linked to nitric oxide synthesis from arginine. J. Neurochem. 53:1989;1952-1954.
13. Grima G., Benz B., Do K.Q. Glutamate-induced release of the nitric oxide precursor arginine, from glial cells. Eur. J. Neurosci. 9:1997;2248-2258.
14. Grima G., Cuénod M., Pfeiffer S., Mayer B., Do K.Q. Arginine availability controls the N-methyl-D-aspartate-induced nitric oxide synthesis: involvement of a glial-neuronal arginine transfer. J. Neurochem. 71:1998;2139-2144.
15. Guevara-Guzman R., Emson P.C., Kendrick K.M. Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP. J. Neurochem. 62:1994;807-810.
16. Y.E. Hsia, Inherited Metabolic Disorders, in: G. Avery, (Ed.), Neonatalogy, Lippincott, Philadelphia, 1975.
17. Justice J.B. Quantitative microdialysis of neurotransmitters. J. Neurosci. Methods. 48:1993;263-276.
18. Kelly P.A.T., Ritchie I.M., Arbuthnott G.W. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat. J. Cereb. Blood Flow Metab. 15:1995;766-773.
19. Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem. J. 298:1994;249-258.
20. Lehman A., Hagberg H., Jacobson I., Hamberger A. Effects of status epilepticus on extracellular amino acids in the hippocampus. Brain Res. 359:1985;147-151.
21. Lei S.Z., Pan Z.H., Aggarwal S.K., Chen H.S., Hartman J., Sucher N.J., Lipton S.A. Effect of nitric oxide production on the redox modulatory site of the NMDA-receptor-channel complex. Neuron. 8:1992;1087-1099.
22. Lothman E.W., Collins R.C. Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res. 218:1981;299-318.
23. Meldrum B.S. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44:1994;S14-S23. Suppl. 8.
24. 31P NMR study in rat Brain Res. 638:1994;53-60.
25. Millan M.H., Chapman A.G., Meldrum B.S. Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. Epilepsy Res. 14:1993;139-148.
26. Montécot C., Borredon J., Seylaz J., Pinard E. Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate. J. Cereb. Blood Flow Metab. 17:1997;94-99.
27. Montécot C., Rondi-Reig L., Springhetti V., Seylaz J., Pinard E. Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures. Neuroscience. 84:1998;791-800.
28. Moore P.K., Babbedge R.C., Wallace P., Gaffen Z.A., Hart S.L. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol. 108:1993;296-297.
29. P.K. Moore, P.A. Bland-Ward, 7-Nitroindazole: an inhibitor of nitric oxide synthase, in: J.N. Abelson, M.I. Simon (Eds.), Methods in Enzymology, Vol. 268, Academic, San Diego, 1996, pp. 393-398.
30. Moore P.K., Wallace P., Gaffen Z., Hart S.L., Babbedge R.C. Characterization of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br. J. Pharmacol. 110:1993;219-224.
31. Mülsch A., Busse R., Mordvintcev P.I., Vanin A.F., Nielsen E.O., Scheel-Krüger J., Olesen S.P. Nitric oxide promotes seizure activity in kainate-treated rats. NeuroReport. 5:1994;2325-2328.
32. Ohta K., Shimazu K., Komatsumoto S., Araki N., Shibata M., Fukuuchi Y. Modification of striatal arginine and citrulline metabolism by nitric oxide synthase inhibitors. NeuroReport. 5:1994;766-768.
33. O'Neill M.J., Hicks C., Ward M. Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. Eur. J. Pharmacol. 310:1996;115-122.
34. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press, Sydney, 1986.
35. Penix L.P., Davis W., Subramanian S. Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. Epilepsy Res. 18:1994;177-184.
36. Pinard E., Rigaud A.S., Riche D., Naquet R., Seylaz J. Continuous determination of the cerebrovascular changes induced by bicuculline and kainic acid in unanaesthetized spontaneously breathing rats. Neuroscience. 23:1987;943-952.
37. 3 region of the hippocampus during kainate-induced seizures. Neuroscience. 13:1984;1039-1049.
38. Pögün S., Dawson V., Kuhar M.J. Nitric oxide inhibits 3H-glutamate transport in synaptosomes. Synapse. 18:1994;21-26.
39. Rigaud-Monnet A.S., Heron A., Seylaz J., Pinard E. Effect of inhibiting NO synthesis on hippocampal extracellular glutamate concentration in seizures induced by kainic acid. Brain Res. 673:1995;297-303.
40. Rigaud-Monnet A.S., Pinard E., Borredon J., Seylaz J. Blockade of nitric oxide synthesis inhibits hippocampal hyperemia in kainic acid-induced seizures. J. Cereb. Blood Flow Metab. 14:1994;581-590.
41. Sadasivudu B., Rao T.I. Studies on functional metabolic role of urea cycle intermediates in the brain. J. Neurochem. 27:1976;785-794.
42. Schulz J.B., Matthews R.T., Jenkins B.G., Ferrante R.J., Siwek D., Henshaw D.R., Cipolloni P.B., Mecocci P., Kowall N.W., Rosen B.R., Beal M.F. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J. Neurosci. 15:1995;8419-8429.
43. Smith S.E., Man C.M., Yip P.K., Tang E., Chapman A.G., Meldrum B.S. Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation. Br. J. Pharmacol. 119:1996;165-173.
44. Sperk G. Kainic acid seizures in the rat. Prog. Neurobiol. 42:1994;1-32.
45. Stone T.W. Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate. Br. J. Pharmacol. 101:1990;8847-8852.
46. Wade J.W., Samson F.E., Nelson S.R., Pazdernik T.L. Changes in extracellular amino acids during soman and kainic acid-induced seizures. J. Neurochem. 49:1987;645-650.
47. Wang Q., Pelligrino D.A., Baughman V.L., Koenig H.M., Albrecht R.F. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J. Cereb. Blood Flow Metab. 15:1995;774-778.
48. Wendland B., Schweizer F.E., Ryan T.A., Nakane M., Murad F., Scheller R.H., Tsien R.W. Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proc. Natl. Acad. Sci. U.S.A. 91:1994;2151-2155.
49. Westergaard N., Beart P.M., Schousboe A. Transport of L-[3H]arginine in cultured neurons: characteristics and inhibition by nitric oxide synthase inhibitors. J. Neurochem. 61:1993;364-367.
50. Yoshida T., Limmroth V., Irikura K., Moskowitz M.A. The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J. Cereb. Blood Flow Metab. 14:1994;924-929.
51. Young A.M.J., Crowder J.M., Bradford H.F. Potentiation by kainate of excitatory amino acid release in striatum: complementary in vivo and in vitro experiments. J. Neurochem. 50:1988;337-345.
52. Zhang J., Snyder S.H. Nitric oxide in the nervous system. Annu. Rev. Pharmacol. Toxicol. 35:1995;213-233.
53. Zhang Y., Samson F.E., Nelson S.R., Pazdernik T.L. Nitric oxide detection with intracerebral microdialysis: important considerations in the application of the hemoglobin-trapping technique. J. Neurosci. Methods. 68:1996;165-173.