Substrate uptake, phosphorus repression, and effect of seed culture on glycopeptide antibiotic production: Process model development and experimental validation

Biotechnology and Bioengineering

Volumn 105, Issue 1, 2010, Pages 109-120

  Maiti, Soumen K ^a   Singh, Kamaleshwar P ^a   Lantz, Anna Eliasson ^b   Bhushan, Mani ^a   Wangikar, Pramod P ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Amycolatopsis balhimycina; Multi substrate media; Parameter estimation; Structured kinetic model

Indexed keywords

AMYCOLATOPSIS BALHIMYCINA; CATABOLITE REPRESSION; CONFIDENCE INTERVAL; EXPERIMENTAL VALIDATIONS; FEEDING STRATEGIES; FILAMENTOUS GROWTH; GLYCOPEPTIDE ANTIBIOTICS; GLYCOPEPTIDES; INDUSTRIAL-SCALE PRODUCTION; KINETIC MODELS; MEDIUM COMPOSITION; METABOLIC PATHWAYS; MODEL PARAMETERS; MODEL SENSITIVITY; OPERATING CONDITION; PHOSPHATE LEVELS; PREDICTIVE ABILITIES; PROCESS MODEL; PRODUCT FORMATION; RATE-LIMITING ENZYMES; SECONDARY METABOLITES; SEED CULTURES; SEED TRANSFER; SUBSTRATE INHIBITION; SUBSTRATE UPTAKE; UPTAKE RATE;

ANTIBIOTICS; FORESTRY; GLUCOSE; GLYCEROL; KINETIC THEORY; METABOLISM; METABOLITES; MODEL CHECKING; OPTIMIZATION; PARAMETER ESTIMATION; PHOSPHORUS; SEED;

SUBSTRATES;

BALHIMYCIN; CARBON; GLUCOSE; GLYCEROL; NITROGEN; PHOSPHORUS; POLYPEPTIDE ANTIBIOTIC AGENT;

ACTINOBACTERIA; AMYCOLATOPSIS BALHIMYCINA DSM5908; ARTICLE; CATABOLITE REPRESSION; DRUG MANUFACTURE; KINETICS; NONHUMAN; PLANT SEED; PROCESS DEVELOPMENT; PROCESS MODEL; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; SENSITIVITY ANALYSIS; VALIDATION STUDY;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; BIOREACTORS; CULTURE MEDIA; GLYCOPEPTIDES; KINETICS; MODELS, STATISTICAL; PHOSPHORUS; REPRODUCIBILITY OF RESULTS;

ACTINOBACTERIA (CLASS); AMYCOLATOPSIS BALHIMYCINA;

EID: 73949116960     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22505     Document Type: Article

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