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Lindsay JA, Holden MTG. Staphylococcus aureus: superbug, super genome? Trends Microbiol 2004; 12:378-385. An outstanding review of the genetics of S. aureus written at a level that is mostly comprehensible to those of us who are not molecular biologists.
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Trends Microbiol
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Lindsay, J.A.1
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Naimi TS, LeDell KH, Como-Sabetti K, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003; 290:2976-2984. This well-done study compares the epidemiologic and microbiologic characteristics of community-associated MRSA cases with nosocomial cases.
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JAMA
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Naimi, T.S.1
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Staphylococcus aureus with reduced susceptibility to vancomycin
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Cosgrove SE, Carroll KC, Perl TM. Staphylococcus aureus with reduced susceptibility to vancomycin. Clin Infect Dis 2004; 39:539-545. An excellent succinct review of the epidemiology, resistance mechanisms, identification, containment and treatment of S. aureus isolates with reduced susceptibility to vancomycin.
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Clin Infect Dis
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Cosgrove, S.E.1
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Bozdogan B, Esel D, Whitener C, et al. Antibacterial susceptibility of a vancomycin-resistant Stapylococcus aureus strain isolated at the Hershey Medical Center. J Antimicrob Chemother 2004; 52:864-868. A comprehensive examination of the antibiotic susceptibility pattern of the second VRSA isolate in the USA.
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Pediatr Infect Dis
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von Eiff C, Lubritz G, Heese C, et al. Effect of trimethoprim- sulfamethoxazole in AIDS patients on the formation of the small colony variant phenotype of Staphyloccoccus aureus. Diagn Microbiol Infect Dis 2004; 48:191-194.
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Reynolds R, Potz N, Colman M, et al. Antimicrobial susceptibility of the pathogens of bactearemia in UK and Ireland 2001-2002: the BSAC Bacteraemia Resistance Surveillance Programme. J Antimicrob Chemother 2004; 53:1018-1032. A very comprehensive assessment of the in vitro activity of 16 antibiotics against 16 common Gram-positive and Gram-negative organisms.
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Pavoni GL, Gianella M, Falcone M, et al. Conservative medical therapy of prosthetic joint infections; retrospective analysis of an 8-year experience. Clin Microbiol Infect 2004; 10:831-837.
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Krut O, Sommer H, Kranke M. Antibiotic-induced persistence of cytotoxic Staphylococcus aureus in non-phagocytic cells. J Antimicrob Chemother 2004; 53:167-173. An interesting paper that examines the effects of antibiotics on bacterial growth in non-phagocytic cells, an issue that has not been addressed previously.
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J Antimicrob Chemother
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Krut, O.1
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Shopsin B, Zhao X, Kreiswirth BN, et al. Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus? Int J Antimicrob Agents 2004; 24:32-34.
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Livermore DM. Linezolid in vitro: mechanism and antibacterial spectrum. J Antimicrob Chemother 2003; 51 (Suppl S2):ii9-ii16. An excellent overview of linezolid's mechanism of action and discussion of its antibacterial spectrum.
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Livermore, D.M.1
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Wunderink RG, Bello J, Cammarata SK, et al. Linezolid vs vancomycin. Analysis of two double-blind studies of patients with methacillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest 2003; 124:1789-1797. This study demonstrates the superiority of linezolid in the treatment of Gram-positive and MRSA nosocomial pneumonia.
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Kollef MH, Rello J, Cammarata SK, et al. Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective retrospective analysis of two double-blind studies comparing linezolid with vancomycin. Intens Care Med 2004; 30:388-394. This is a seminal study that demonstrates the superiority of linezolid in the treatment of ventilator-associated Gram-positive and MRSA pneumonia.
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Intens Care Med
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Kollef, M.H.1
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Ioanas M, Lode H. Linezolid in VAP by MRSA: better choice? Intens Care Med 2004; 30:343-346.
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Rayner CR, Baddour LM, Birmingham MC, et al. Linezolid in the treatment of osteomyelitis: results of a compassionate use experience. Infection 2004; 32:8-14.
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Kutscha-Lissberg F, Hebler U, Muhr G, Koller M. Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci. Antimicrob Agents Chemother 2003; 47:3964-3966. A well-done study that examines penetration of linezolid into infected bone and periarticular tissue.
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Kutscha-Lissberg, F.1
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Lipsky BA, Itani K, Norden C, Linezolid Diabetic Foot Infection Study Group. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampillin-sulbactam/amoxicillin- clavulanate. Clin Infect Dis 2004; 38:17-24. This is the largest published trial of the outcome of treating diabetic foot infections (n = 371). For patients with foot ulcers, 81% were cured in the linezolid arm, compared with 68% in the aminopenicillin-β-lactamase inhibitor arm (P = 0.018). For patients without osteomyelitis, 87% were cured in the linezolid group, compared with 72% in the comparator (P = 0.003). Linezolid was associated with more-adverse effects, but there were similar rates of discontinuation of study drugs in both arms of the trial. In the subset of linezolid-treated patients infected with both Gram-positive and Gram-negative bacteria, clinical success rates were similar regardless of whether aztreonam was added, indicating that treating the Gram-positive organisms is more important to the outcome.
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Lipsky, B.A.1
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Nasaraway SA, Short AF, Kuter DJ, et al. Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use. Clin Infect Dis 2003; 37:1609-1616. Nasaraway et al. assessed the risk of thrombocytopenia in 686 patients with nosocomial pneumonia who received linezolid or vancomycin for ≥5 days. New-onset thrombocytopenia occurred in 6.4% of the linezolid patients compared with 7.7% of those receiving vancomycin.
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