Detection of lymphovascular invasion in vulvar cancer by D2-40 (Podoplanin) as a predictor for inguinal lymph node metastases

Onkologie

Volumn 32, Issue 12, 2009, Pages 732-738

  Braun, Michael ^a,b   Wardelmann, Eva ^a,b   Debald, Manuel ^a,b   Walgenbach Bruenagel, Gisela ^a,b   Höller, Tobias ^a,b   Wolfgarten, Matthias ^a,b   Sauerwald, Axel ^a,b   Rudlowski, Christian ^a,b   Büttner, Reinhard ^a,b   Kuhn, Walther ^a,b   Pölcher, Martin ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b University of Cologne   (Germany)

Author keywords

D2 40; Lymphangiosis; Regional lymph node metastases; Vulvar cancer

Indexed keywords

EOSIN; FORMALDEHYDE; HEMATOXYLIN; MONOCLONAL ANTIBODY D2-40; PARAFFIN;

ADULT; AGED; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INGUINAL LYMPH NODE; LYMPH NODE METASTASIS; PREDICTION; REGIONAL METASTASIS; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; VULVA CANCER;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; FEMALE; GROIN; HUMANS; INGUINAL CANAL; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; VULVAR NEOPLASMS;

EID: 73949098035     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000252795     Document Type: Article

References (42)

1. Stroup AM, Harlan LC, Trimble EL: Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States. Gynecol Oncol 2008;108:577-583.
2. Homesley HD, Bundy BN, Sedlis A, Yordan E, Berek JS, Jahshan A, Mortel R: Assessment of current International Federation of Gynecology and Obstetrics staging of vulvar carcinoma relative to prognostic factors for survival (a Gynecologic Oncology Group study). Am J Obstet Gynecol 1991; 164:997-1003; discussion 1003-1004.
3. Sago N, Nakao Y, Iwasaka T: [Prognostic factors of vulvar cancer]. Gan To Kagaku Ryoho 2006;33: 1991-1997.
4. Boyce J, Fruchter RG, Kasambilides E, Nicastri AD, Sedlis A, Remy JC: Prognostic factors in carcinoma of the vulva. Gynecol Oncol 1985;20:364-377.
5. Sedlis A, Homesley H, Bundy BN, Marshall R, Yordan E, Hacker N, Lee JH, Whitney C: Positive groin lymph nodes in superficial squamous cell vulvar cancer. A Gynecologic Oncology Group study. Am J Obstet Gynecol 1987;156:1159-1164.
6. Stehman FB, Look KY: Carcinoma of the vulva. Obstet Gynecol 2006;107:719-733.
7. Heaps JM, Fu YS, Montz FJ, Hacker NF, Berek JS: Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990:38:309-314.
8. Thomas GM, Dembo AJ, Bryson SC, Osborne R, DePetrillo AD: Changing concepts in the management of vulvar cancer. Gynecol Oncol 1991;42:9-21.
9. Faul CM, Mirmow D, Huang Q, Gerszten K, Day R, Jones MW: Adjuvant radiation for vulvar carcinoma: improved local control. Int J Radiat Oncol Biol Phys 1997;38:381-389.
10. Van Der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van Der Velden J, Hermans RH, van Der Putten H, Drouin P, Schneider A, Sluiter WJ: Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 2008;26:884-889.
11. Katz A, Eifel PJ, Jhingran A, Levenback CF: The role of radiation therapy in preventing regional recurrences of invasive squamous cell carcinoma of the vulva. Int J Radiat Oncol Biol Phys 2003;57: 409-418.
12. Alexander-Sefre F, Singh N, Ayhan A, Salveson HB, Wilbanks G, Jacobs IJ: Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol 2003;56:786-788.
13. Gombos Z, Xu X, Chu CS, Zhang PJ, Acs G: Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 2005;11:8364-8371.
14. Arnaout-Alkarain A, Kahn HJ, Narod SA, Sun PA, Marks AN: Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer. Mod Pathol 2007;20:183-191.
15. Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M: Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005; 166:913-921.
16. Kahn HJ, Marks A: A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 2002;82:1255-1257.
17. Evangelou E, Kyzas PA, Trikalinos TA: Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach. Mod Pathol 2005;18:1490-1497.
18. Braun M, Flucke U, Debald M, Walgenbach-Bruenagel G, Walgenbach KJ, Holler T, Polcher M, Wolfgarten M, Sauerwald A, Keyver-Paik M, Kuhr M, Buttner R, Kuhn W: Detection of lymphovascular invasion in early breast cancer by D2-(podoplanin): a clinically useful predictor for axillary lymph node metastases. Breast Cancer Res Treat 2008;112:503-511.
19. Debald M, Pölcher M, Flucke U, Walgenbach-Bruenagel G, Walgenbach KJ, Höller T, Wolfgarten M, Rudlowski C, Büttner R, Schild H, Kuhn W, Braun M: Increased detection of lymphatic vessel invasion by D2-40 (podoplanin) in early breast cancer: possible influence on patient selection for accelerated partial breast irradiation (APBI). Int J Radiat Oncol Biol Phys 2009, in press.
20. Juretzka MM, Jensen KC, Longacre TA, Teng NN, Husain A: Detection of pelvic lymph node micrometastasis in stage IA2-IB2 cervical cancer by immunohistochemical analysis. Gynecol Oncol 2004;93:107-111.
21. Miettinen M, Lindenmayer AE, Chaubal A: Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens - evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with Von Willebrand factor. Mod Pathol 1994;7:82-90.
22. Fukunaga M: Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology 2005;46:396-402.
23. Jackson DG, Prevo R, Clasper S, Banerji S: LYVE-1, the lymphatic system and tumor lymphangiogenesis. Trends Immunol 2001;22:317-321.
24. Pepper MS: Lymphangiogenesis and tumor metastasis: myth or reality? Clin Cancer Res 2001;7:462-468.
25. Sleeman JP, Krishnan J, Kirkin V, Baumann P: Markers for the lymphatic endothelium: in search of the holy grail? Microsc Res Tech 2001;55:61-69.
26. Jain RK: Transport of molecules across tumor vasculature. Cancer Metastasis Rev 1987;6:559-593.
27. Carmeliet P, Jain RK: Angiogenesis in cancer and other diseases. Nature 2000; 407:249-257.
28. Weaver DL: Sentinel lymph node biopsy in breast cancer: creating controversy and defining new standards. Adv Anat Pathol 2001;8:65-73.
29. Acs G, Dumoff KL, Solin LJ, Pasha T, Xu X, Zhang PJ: Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma. Am J Surg Pathol 2007;31:129-140.
30. Walgenbach-Bruenagel G, Tolba RH, Varnai AD, Bollmann M, Hirner A, Walgenbach KJ: Detection of lymphatic invasion in early stage primary colorectal cancer with the monoclonal antibody D2-40. Eur Surg Res 2006;38:438-444.
31. Braun M, Flucke U, Debald M, Walgenbach-Bruenagel G, Walgenbach KJ, Holler T, Polcher M, Wolfgarten M, Sauerwald A, Keyver-Paik M, Kuhr M, Buttner R, Kuhn W: Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): a clinically useful predictor for axillary lymph node metastases. Breast Cancer Res Treat 2008;112:503-511.
32. Coindre JM: Immunohistochemistry in the diagnosis of soft tissue tumours. Histopathology 2003;43:1-16.
33. Lee AK, DeLellis RA, Wolfe HJ: Intramammary lymphatic invasion in breast carcinomas. Evaluation using ABH isoantigens as endothelial markers. Am J Surg Pathol 1986;10:589-594.
34. Saigo PE, Rosen PP: The application of immunohistochemical stains to identify endothelial-lined channels in mammary carcinoma. Cancer 1987;59:51-54.
35. Lee AK, DeLellis RA, Silverman ML, Heatley GJ, Wolfe HJ: Prognostic significance of peritumoral lymphatic and blood vessel invasion in node-negative carcinoma of the breast. J Clin Oncol 1990;8:1457-1465.
36. Kato T, Kameoka S, Kimura T, Nishikawa T, Kobayashi M: The combination of angiogenesis and blood vessel invasion as a prognostic indicator in primary breast cancer. Br J Cancer 2003;88:1900-1908.
37. Wilkinson EJ: Superficially invasive carcinoma of the vulva. Clin Obstet Gynecol 1991;34:651-661.
38. Benedet JL, Bender H, Jones H, 3rd, Ngan HY, Pecorelli S: FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 2000;70:209-262.
39. Preti M, Ronco G, Ghiringhello B, Micheletti L: Recurrent squamous cell carcinoma of the vulva: clinicopathologic determinants identifying low risk patients. Cancer 2000;88:1869-1876.
40. Homesley HD, Bundy BN, Sedlis A, Yordan E, Berek JS, Jahshan A, Mortel R: Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study). Gynecol Oncol 1993;49:279-283.
41. Hampl M, Hantschmann P, Michels W, Hillemanns P: Validation of the accuracy of the sentinel lymph node procedure in patients with vulvar cancer: results of a multicenter study in Germany. Gynecol Oncol 2008;111:282-288.
42. Binder SW, Huang I, Fu YS, Hacker NF, Berek JS: Risk factors for the development of lymph node metastasis in vulvar squamous cell carcinoma. Gynecol Oncol 1990;37:9-16.