-
1
-
-
0037819284
-
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
-
Guillemette C. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 2003; 3:136-158.
-
(2003)
Pharmacogenomics J
, vol.3
, pp. 136-158
-
-
Guillemette, C.1
-
2
-
-
25144500468
-
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
-
Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 2005; 15:677-685.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 677-685
-
-
MacKenzie, P.I.1
Bock, K.W.2
Burchell, B.3
Guillemette, C.4
Ikushiro, S.5
Iyanagi, T.6
-
3
-
-
59649084478
-
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly
-
Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, Finel M. UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos 2009; 37:417-423.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 417-423
-
-
Sten, T.1
Bichlmaier, I.2
Kuuranne, T.3
Leinonen, A.4
Yli-Kauhaluoma, J.5
Finel, M.6
-
4
-
-
0034966656
-
Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus
-
Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, et al. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 2001; 11:357-368.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 357-368
-
-
Gong, Q.H.1
Cho, J.W.2
Huang, T.3
Potter, C.4
Gholami, N.5
Basu, N.K.6
-
5
-
-
0029962074
-
Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
-
Green MD, Tephly TR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 1996; 24:356-363.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 356-363
-
-
Green, M.D.1
Tephly, T.R.2
-
6
-
-
0031765698
-
Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
-
Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 1998; 26:507-512.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 507-512
-
-
Green, M.D.1
King, C.D.2
Mojarrabi, B.3
MacKenzie, P.I.4
Tephly, T.R.5
-
7
-
-
0034128936
-
Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
-
Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40:581-616.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 581-616
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
8
-
-
30144436526
-
Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
-
Court MH. Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases. Methods Enzymol 2005; 400:104-116.
-
(2005)
Methods Enzymol
, vol.400
, pp. 104-116
-
-
Court, M.H.1
-
9
-
-
0034942927
-
N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo ( 4,5-b) pyridine (PhIP) and N-hydroxy-PhIP by specific human UDP-glucuronosyltransferases
-
Malfatti MA, Felton JS. N-glucuronidation of 2-amino-1-methyl-6- phenylimidazo (4,5-b) pyridine (PhIP) and N-hydroxy-PhIP by specific human UDP-glucuronosyltransferases. Carcinogenesis 2001; 22:1087-1093.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1087-1093
-
-
Malfatti, M.A.1
Felton, J.S.2
-
10
-
-
23044471764
-
UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver
-
Girard H, Thibaudeau J, Court MH, Fortier LC, Villeneuve L, Caron P, et al. UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver. Hepatology 2005; 42:448-457.
-
(2005)
Hepatology
, vol.42
, pp. 448-457
-
-
Girard, H.1
Thibaudeau, J.2
Court, M.H.3
Fortier, L.C.4
Villeneuve, L.5
Caron, P.6
-
11
-
-
2342572781
-
Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4
-
Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem Pharmacol 2004; 67:2093-2102.
-
(2004)
Biochem Pharmacol
, vol.67
, pp. 2093-2102
-
-
Kaku, T.1
Ogura, K.2
Nishiyama, T.3
Ohnuma, T.4
Muro, K.5
Hiratsuka, A.6
-
12
-
-
61649101234
-
Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen
-
Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D. Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Ann N Y Acad Sci 2009; 1155:99-111.
-
(2009)
Ann N y Acad Sci
, vol.1155
, pp. 99-111
-
-
Lazarus, P.1
Blevins-Primeau, A.S.2
Zheng, Y.3
Sun, D.4
-
13
-
-
0027500825
-
Analysis of phase i and phase II metabolites of tamoxifen in breast cancer patients
-
Poon GK, Chui YC, McCague R, Llnning PE, Feng R, Rowlands MG, et al. Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients. Drug Metab Dispos 1993; 21:1119-1124.
-
(1993)
Drug Metab Dispos
, vol.21
, pp. 1119-1124
-
-
Poon, G.K.1
Chui, Y.C.2
McCague, R.3
Llnning, P.E.4
Feng, R.5
Rowlands, M.G.6
-
14
-
-
33748318005
-
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants
-
Sun D, Chen G, Dellinger RW, Duncan K, Fang JL, Lazarus P. Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. Breast Cancer Res 2006; 8:R50.
-
(2006)
Breast Cancer Res
, vol.8
-
-
Sun, D.1
Chen, G.2
Dellinger, R.W.3
Duncan, K.4
Fang, J.L.5
Lazarus, P.6
-
15
-
-
1842532189
-
Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
-
Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology 2004; 39:970-977.
-
(2004)
Hepatology
, vol.39
, pp. 970-977
-
-
Ehmer, U.1
Vogel, A.2
Schutte, J.K.3
Krone, B.4
Manns, M.P.5
Strassburg, C.P.6
-
16
-
-
21444439973
-
Genetic variations and haplotypes of UGT1A4 in a Japanese population
-
Saeki M, Saito Y, Jinno H, Sai K, Hachisuka A, Kaniwa N, et al. Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab Pharmacokinet 2005; 20:144-151.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 144-151
-
-
Saeki, M.1
Saito, Y.2
Jinno, H.3
Sai, K.4
Hachisuka, A.5
Kaniwa, N.6
-
17
-
-
63749097656
-
Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population
-
Menard V, Girard H, Harvey M, Perusse L, Guillemette C. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. Hum Mutat 2009; 30:677-687.
-
(2009)
Hum Mutat
, vol.30
, pp. 677-687
-
-
Menard, V.1
Girard, H.2
Harvey, M.3
Perusse, L.4
Guillemette, C.5
-
18
-
-
0842325733
-
Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes
-
Wiener D, Fang JL, Dossett N, Lazarus P. Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone glucuronidation phenotype in human liver microsomes. Cancer Res 2004; 64:1190-1196.
-
(2004)
Cancer Res
, vol.64
, pp. 1190-1196
-
-
Wiener, D.1
Fang, J.L.2
Dossett, N.3
Lazarus, P.4
-
19
-
-
45049084272
-
Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene
-
Erichsen TJ, Ehmer U, Kalthoff S, Lankisch TO, Muller TM, Munzel PA, et al. Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol 2008; 230:252-260.
-
(2008)
Toxicol Appl Pharmacol
, vol.230
, pp. 252-260
-
-
Erichsen, T.J.1
Ehmer, U.2
Kalthoff, S.3
Lankisch, T.O.4
Muller, T.M.5
Munzel, P.A.6
-
20
-
-
33847659653
-
The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers
-
Levesque E, Delage R, Benoit-Biancamano MO, Caron P, Bernard O, Couture F, et al. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. Clin Pharmacol Ther 2007; 81:392-400.
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 392-400
-
-
Levesque, E.1
Delage, R.2
Benoit-Biancamano, M.O.3
Caron, P.4
Bernard, O.5
Couture, F.6
-
21
-
-
0037369609
-
Heterocyclic amines, meat intake, and association with colon cancer in a population-based study
-
Butler LM, Sinha R, Millikan RC, Martin CF, Newman B, Gammon MD, et al. Heterocyclic amines, meat intake, and association with colon cancer in a population-based study. Am J Epidemiol 2003; 157:434-445.
-
(2003)
Am J Epidemiol
, vol.157
, pp. 434-445
-
-
Butler, L.M.1
Sinha, R.2
Millikan, R.C.3
Martin, C.F.4
Newman, B.5
Gammon, M.D.6
-
22
-
-
4143072423
-
Identification of common polymorphisms in the promoter of the UGT1A9 gene: Evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver
-
Girard H, Court MH, Bernard O, Fortier LC, Villeneuve L, Hao Q, et al. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 2004; 14:501-515.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 501-515
-
-
Girard, H.1
Court, M.H.2
Bernard, O.3
Fortier, L.C.4
Villeneuve, L.5
Hao, Q.6
-
23
-
-
0036842042
-
Stereoselective conjugation of oxazepam by human UDP- glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9
-
Court MH, Duan SX, Guillemette C, Journault K, Krishnaswamy S, Von Moltke LL, et al. Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos 2002; 30:1257-1265.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1257-1265
-
-
Court, M.H.1
Duan, S.X.2
Guillemette, C.3
Journault, K.4
Krishnaswamy, S.5
Von Moltke, L.L.6
-
24
-
-
0033789766
-
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene
-
Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10:629-644.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 629-644
-
-
Guillemette, C.1
Ritter, J.K.2
Auyeung, D.J.3
Kessler, F.K.4
Housman, D.E.5
-
25
-
-
0141519502
-
Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
-
Villeneuve L, Girard H, Fortier LC, Gagne JF, Guillemette C. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 2003; 307:117-128.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 117-128
-
-
Villeneuve, L.1
Girard, H.2
Fortier, L.C.3
Gagne, J.F.4
Guillemette, C.5
-
26
-
-
0036765309
-
Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
-
Gagne JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62:608-617.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 608-617
-
-
Gagne, J.F.1
Montminy, V.2
Belanger, P.3
Journault, K.4
Gaucher, G.5
Guillemette, C.6
-
27
-
-
3242695875
-
The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
-
Bernard O, Guillemette C. The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants. Drug Metab Dispos 2004; 32:775-778.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 775-778
-
-
Bernard, O.1
Guillemette, C.2
-
28
-
-
33747040567
-
The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice
-
Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Belanger J, Kaeding J, et al. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 2006; 44:368-378.
-
(2006)
Hepatology
, vol.44
, pp. 368-378
-
-
Verreault, M.1
Senekeo-Effenberger, K.2
Trottier, J.3
Bonzo, J.A.4
Belanger, J.5
Kaeding, J.6
-
29
-
-
17844379707
-
UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation
-
Mori A, Maruo Y, Iwai M, Sato H, Takeuchi Y. UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Drug Metab Dispos 2005; 33:672-675.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 672-675
-
-
Mori, A.1
Maruo, Y.2
Iwai, M.3
Sato, H.4
Takeuchi, Y.5
-
30
-
-
33845943032
-
Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha
-
Gardner-Stephen DA, Mackenzie PI. Isolation of the UDP- glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha. Drug Metab Dispos 2007; 35:116-120.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 116-120
-
-
Gardner-Stephen, D.A.1
MacKenzie, P.I.2
-
31
-
-
0034057412
-
Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter
-
Ishii Y, Hansen AJ, Mackenzie PI. Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. Mol Pharmacol 2000; 57:940-947.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 940-947
-
-
Ishii, Y.1
Hansen, A.J.2
MacKenzie, P.I.3
|