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Volumn 19, Issue 12, 2009, Pages 945-954

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4

Author keywords

Pharmacogenetics; Polymorphisms; Tamoxifen; UDP glucuronosyltransferase; UGT1A4

Indexed keywords

4 HYDROXYTAMOXIFEN; GLUCURONOSYLTRANSFERASE 1A4; HEPATOCYTE NUCLEAR FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 1; TAMOXIFEN;

EID: 73949095106     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283331637     Document Type: Article
Times cited : (46)

References (31)
  • 1
    • 0037819284 scopus 로고    scopus 로고
    • Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
    • Guillemette C. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 2003; 3:136-158.
    • (2003) Pharmacogenomics J , vol.3 , pp. 136-158
    • Guillemette, C.1
  • 3
    • 59649084478 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly
    • Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, Finel M. UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos 2009; 37:417-423.
    • (2009) Drug Metab Dispos , vol.37 , pp. 417-423
    • Sten, T.1    Bichlmaier, I.2    Kuuranne, T.3    Leinonen, A.4    Yli-Kauhaluoma, J.5    Finel, M.6
  • 4
    • 0034966656 scopus 로고    scopus 로고
    • Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus
    • Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, et al. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 2001; 11:357-368.
    • (2001) Pharmacogenetics , vol.11 , pp. 357-368
    • Gong, Q.H.1    Cho, J.W.2    Huang, T.3    Potter, C.4    Gholami, N.5    Basu, N.K.6
  • 5
    • 0029962074 scopus 로고    scopus 로고
    • Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
    • Green MD, Tephly TR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 1996; 24:356-363.
    • (1996) Drug Metab Dispos , vol.24 , pp. 356-363
    • Green, M.D.1    Tephly, T.R.2
  • 6
    • 0031765698 scopus 로고    scopus 로고
    • Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
    • Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 1998; 26:507-512.
    • (1998) Drug Metab Dispos , vol.26 , pp. 507-512
    • Green, M.D.1    King, C.D.2    Mojarrabi, B.3    MacKenzie, P.I.4    Tephly, T.R.5
  • 7
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 8
    • 30144436526 scopus 로고    scopus 로고
    • Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
    • Court MH. Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases. Methods Enzymol 2005; 400:104-116.
    • (2005) Methods Enzymol , vol.400 , pp. 104-116
    • Court, M.H.1
  • 9
    • 0034942927 scopus 로고    scopus 로고
    • N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo ( 4,5-b) pyridine (PhIP) and N-hydroxy-PhIP by specific human UDP-glucuronosyltransferases
    • Malfatti MA, Felton JS. N-glucuronidation of 2-amino-1-methyl-6- phenylimidazo (4,5-b) pyridine (PhIP) and N-hydroxy-PhIP by specific human UDP-glucuronosyltransferases. Carcinogenesis 2001; 22:1087-1093.
    • (2001) Carcinogenesis , vol.22 , pp. 1087-1093
    • Malfatti, M.A.1    Felton, J.S.2
  • 10
    • 23044471764 scopus 로고    scopus 로고
    • UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver
    • Girard H, Thibaudeau J, Court MH, Fortier LC, Villeneuve L, Caron P, et al. UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver. Hepatology 2005; 42:448-457.
    • (2005) Hepatology , vol.42 , pp. 448-457
    • Girard, H.1    Thibaudeau, J.2    Court, M.H.3    Fortier, L.C.4    Villeneuve, L.5    Caron, P.6
  • 11
    • 2342572781 scopus 로고    scopus 로고
    • Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4
    • Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem Pharmacol 2004; 67:2093-2102.
    • (2004) Biochem Pharmacol , vol.67 , pp. 2093-2102
    • Kaku, T.1    Ogura, K.2    Nishiyama, T.3    Ohnuma, T.4    Muro, K.5    Hiratsuka, A.6
  • 12
    • 61649101234 scopus 로고    scopus 로고
    • Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen
    • Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D. Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Ann N Y Acad Sci 2009; 1155:99-111.
    • (2009) Ann N y Acad Sci , vol.1155 , pp. 99-111
    • Lazarus, P.1    Blevins-Primeau, A.S.2    Zheng, Y.3    Sun, D.4
  • 14
  • 15
    • 1842532189 scopus 로고    scopus 로고
    • Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
    • Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology 2004; 39:970-977.
    • (2004) Hepatology , vol.39 , pp. 970-977
    • Ehmer, U.1    Vogel, A.2    Schutte, J.K.3    Krone, B.4    Manns, M.P.5    Strassburg, C.P.6
  • 17
    • 63749097656 scopus 로고    scopus 로고
    • Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population
    • Menard V, Girard H, Harvey M, Perusse L, Guillemette C. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. Hum Mutat 2009; 30:677-687.
    • (2009) Hum Mutat , vol.30 , pp. 677-687
    • Menard, V.1    Girard, H.2    Harvey, M.3    Perusse, L.4    Guillemette, C.5
  • 18
    • 0842325733 scopus 로고    scopus 로고
    • Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes
    • Wiener D, Fang JL, Dossett N, Lazarus P. Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone glucuronidation phenotype in human liver microsomes. Cancer Res 2004; 64:1190-1196.
    • (2004) Cancer Res , vol.64 , pp. 1190-1196
    • Wiener, D.1    Fang, J.L.2    Dossett, N.3    Lazarus, P.4
  • 19
    • 45049084272 scopus 로고    scopus 로고
    • Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene
    • Erichsen TJ, Ehmer U, Kalthoff S, Lankisch TO, Muller TM, Munzel PA, et al. Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol 2008; 230:252-260.
    • (2008) Toxicol Appl Pharmacol , vol.230 , pp. 252-260
    • Erichsen, T.J.1    Ehmer, U.2    Kalthoff, S.3    Lankisch, T.O.4    Muller, T.M.5    Munzel, P.A.6
  • 20
    • 33847659653 scopus 로고    scopus 로고
    • The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers
    • Levesque E, Delage R, Benoit-Biancamano MO, Caron P, Bernard O, Couture F, et al. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. Clin Pharmacol Ther 2007; 81:392-400.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 392-400
    • Levesque, E.1    Delage, R.2    Benoit-Biancamano, M.O.3    Caron, P.4    Bernard, O.5    Couture, F.6
  • 21
    • 0037369609 scopus 로고    scopus 로고
    • Heterocyclic amines, meat intake, and association with colon cancer in a population-based study
    • Butler LM, Sinha R, Millikan RC, Martin CF, Newman B, Gammon MD, et al. Heterocyclic amines, meat intake, and association with colon cancer in a population-based study. Am J Epidemiol 2003; 157:434-445.
    • (2003) Am J Epidemiol , vol.157 , pp. 434-445
    • Butler, L.M.1    Sinha, R.2    Millikan, R.C.3    Martin, C.F.4    Newman, B.5    Gammon, M.D.6
  • 22
    • 4143072423 scopus 로고    scopus 로고
    • Identification of common polymorphisms in the promoter of the UGT1A9 gene: Evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver
    • Girard H, Court MH, Bernard O, Fortier LC, Villeneuve L, Hao Q, et al. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 2004; 14:501-515.
    • (2004) Pharmacogenetics , vol.14 , pp. 501-515
    • Girard, H.1    Court, M.H.2    Bernard, O.3    Fortier, L.C.4    Villeneuve, L.5    Hao, Q.6
  • 23
    • 0036842042 scopus 로고    scopus 로고
    • Stereoselective conjugation of oxazepam by human UDP- glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9
    • Court MH, Duan SX, Guillemette C, Journault K, Krishnaswamy S, Von Moltke LL, et al. Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos 2002; 30:1257-1265.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1257-1265
    • Court, M.H.1    Duan, S.X.2    Guillemette, C.3    Journault, K.4    Krishnaswamy, S.5    Von Moltke, L.L.6
  • 24
    • 0033789766 scopus 로고    scopus 로고
    • Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene
    • Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10:629-644.
    • (2000) Pharmacogenetics , vol.10 , pp. 629-644
    • Guillemette, C.1    Ritter, J.K.2    Auyeung, D.J.3    Kessler, F.K.4    Housman, D.E.5
  • 25
    • 0141519502 scopus 로고    scopus 로고
    • Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
    • Villeneuve L, Girard H, Fortier LC, Gagne JF, Guillemette C. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 2003; 307:117-128.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 117-128
    • Villeneuve, L.1    Girard, H.2    Fortier, L.C.3    Gagne, J.F.4    Guillemette, C.5
  • 26
    • 0036765309 scopus 로고    scopus 로고
    • Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
    • Gagne JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62:608-617.
    • (2002) Mol Pharmacol , vol.62 , pp. 608-617
    • Gagne, J.F.1    Montminy, V.2    Belanger, P.3    Journault, K.4    Gaucher, G.5    Guillemette, C.6
  • 27
    • 3242695875 scopus 로고    scopus 로고
    • The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
    • Bernard O, Guillemette C. The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants. Drug Metab Dispos 2004; 32:775-778.
    • (2004) Drug Metab Dispos , vol.32 , pp. 775-778
    • Bernard, O.1    Guillemette, C.2
  • 28
    • 33747040567 scopus 로고    scopus 로고
    • The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice
    • Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Belanger J, Kaeding J, et al. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 2006; 44:368-378.
    • (2006) Hepatology , vol.44 , pp. 368-378
    • Verreault, M.1    Senekeo-Effenberger, K.2    Trottier, J.3    Bonzo, J.A.4    Belanger, J.5    Kaeding, J.6
  • 29
    • 17844379707 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation
    • Mori A, Maruo Y, Iwai M, Sato H, Takeuchi Y. UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Drug Metab Dispos 2005; 33:672-675.
    • (2005) Drug Metab Dispos , vol.33 , pp. 672-675
    • Mori, A.1    Maruo, Y.2    Iwai, M.3    Sato, H.4    Takeuchi, Y.5
  • 30
    • 33845943032 scopus 로고    scopus 로고
    • Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha
    • Gardner-Stephen DA, Mackenzie PI. Isolation of the UDP- glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha. Drug Metab Dispos 2007; 35:116-120.
    • (2007) Drug Metab Dispos , vol.35 , pp. 116-120
    • Gardner-Stephen, D.A.1    MacKenzie, P.I.2
  • 31
    • 0034057412 scopus 로고    scopus 로고
    • Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter
    • Ishii Y, Hansen AJ, Mackenzie PI. Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. Mol Pharmacol 2000; 57:940-947.
    • (2000) Mol Pharmacol , vol.57 , pp. 940-947
    • Ishii, Y.1    Hansen, A.J.2    MacKenzie, P.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.