β 2 -adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells

Cellular Physiology and Biochemistry

Volumn 25, Issue 1, 2010, Pages 123-134

  Loeh, Benjamin ^a   Baloglu, Emel ^a   Ke, Alberto ^a   Bärtsch, Peter ^a   Mairbäurl, Heimo ^a  

^a NONE

Author keywords

ENaC; Pulmonary edema

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMILORIDE; AMPHOTERICIN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; EPITHELIAL SODIUM CHANNEL; MESSENGER RNA; TERBUTALINE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ACUTE DRUG ADMINISTRATION; ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CELL HYPOXIA; CHLORIDE CURRENT; CHLORIDE TRANSPORT; CONTROLLED STUDY; ION TRANSPORT; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT CIRCUIT CURRENT; SODIUM TRANSPORT; ANIMAL; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; LUNG ALVEOLUS CELL; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ADRENERGIC BETA-AGONISTS; ANIMALS; CELL HYPOXIA; CELLS, CULTURED; ION TRANSPORT; MALE; PNEUMOCYTES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; TERBUTALINE;

EID: 73849127373     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000272057     Document Type: Article

References (46)

1. Matthay MA, Abraham E: Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med 2006;173:254-255.
2. Sartori C, Allemann Y, Duplain H, Lepori M, Egli M, Lipp E, Hutter D, Turini P, Hugli O, Cook S, Nicod P, Scherrer U: Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 2002;346:1631-1636.
3. Ware LB, Matthay MA: Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1376-1383.
4. Matalon S, O'Brodovich H: Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Ann Rev Physiol 1999;61:627-661.
5. Planes C, Escoubet B, BlotChabaud M, Friedlander G, Farman N, Clerici C: Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Molec Biol 1997;17:508-518.
6. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall ED: Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Molec Physiol 2002;282:L659-L665.
7. Vivona ML, Matthay MA, Chabaud MB, Friedlander G, Clerici C: Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Molec Biol 2001;25:554-561.
8. Guney S, Schuler A, Ott A, Höschele S, Baloglu E, Bärtsch P, Mairbäurl H: Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na/K-ATPase and ENaC. Am J Physiol Lung Cell Mol Physiol 2007;293:L1332-L1338.
9. Planes C, BlotChabaud M, Matthay MA, Couette S, Uchida T, Clerici C: Hypoxia and beta(2)-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 2002;277:47318-47324.
10. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI: Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 2003;111:1057-1064.
11. Bebök Z, Tousson A, Schwiebert LM, Venglarik CJ: Improved oxygenation promotes CFTR maturation and trafficking in MDCK monolayers. Am J Physiol 2001;280:C135-C145.
12. Matthay MA, Folkesson HG, Clerici C: Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 2002;82:569-600.
13. Mutlu GM, Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, Matalon S, Hollenberg S, Factor P: Upregulation of alveolar epithelial active Na+ transport is dependent on beta(2)-adrenergic receptor signaling. Circ Res 2004;94:1091-1100.
14. Perkins GD, McAuley DF, Thickett DR, Gao F: The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006;173:281-287.
15. Frank JA, Wang Y, Osorio O, Matthay MA: Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol 2000;89:1255-1265.
16. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA: Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med 1997;156:438-444.
17. Fang XH, Song YL, Hirsch J, Galietta LJV, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA: Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Amer J Physiol Lung Cell M Ph 2006;290:L242-L249.
18. + -ATPase by cAMP and dexamethasone in alveolar epithelial cells. Am J Physiol 2001;281:L217-L230.
19. Baloglu E, Ke A, Abu-Taha IH, Bärtsch P, Mairbäurl H: In vitro hypoxia impairs beta 2 adrenergic signaling in primary rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009;296:L500-L509.
20. Litvan J, Briva A, Wilson MS, Budinger GR, Sznajder JI, Ridge KM: Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption. J Biol Chem 2006;281:19892-19898.
21. Dehler M, Zessin E, Bärtsch P, Mairbäurl H: Hypoxia causes permeability edema in the constant-pressure perfused rat lung. Eur Respir J 2006;27:600-606.
22. Duplain H, Vollenweider L, Delabays A, Nicod P, Bartsch P, Scherrer U: Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 1999;99:1713-1718.
23. 2 -agonists to increase alveolar liquid clearance. Am J Physiol Lung Cell Molec Physiol 2002;282:L666-L674.
24. Loeh B, Bärtsch P, Mairbäurl H. Downregulation of beta receptor signalling in alveolar epithelial cells in hypoxia. Acta Physiologica 186, 68/ OM06-32. 2006.
25. Loeh B, Bärtsch P, Mairbäurl H. Pretreatment with beta-agonists stimulates alveolar Na-transport in normoxia and hypoxia. Faseb J 2005;19:A173.
26. Dobbs LG: Isolation and culture of alveolar type II cells. Am J Physiol 1990;258:L134-L147.
27. + absorption across alveolar type II monolayers. Am J Physiol 1998;274:L369-L377.
28. Mason RJ, Williams MC, Widdicombe JH, Sanders MJ, Misfeldt DS, Berry LCJr: Transepithelial transport by pulmonary alveolar type II cells in primary culture. Proc Natl Acad Sci USA 1982;79:6033-6037.
29. Cott GR, Sugahara K, Mason RJ: Stimulation of net ion transport across alveolar type II cell monolayers. Am J Physiol 1986;250:C222-C227.
30. Cheek JM, Kim KJ, Crandall ED: Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport. Am J Physiol 1989;256:C688-C693.
31. Blaug S, Hybiske K, Cohn J, Firestone GL, Machen TE, Miller SS: ENaC-and CFTR-dependent ion and fluid transport in mammary epithelia. Am J Physiol Cell Physiol 2001;281:C633-C648.
32. + transport across alveolar epithelial cells involves activation of apical Cl-channels. Am J Physiol Cell Physiol 1998;44:C1610-C1620.
33. O'Grady SM, Jiang X, Ingbar DH: Cl-channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L239-L244.
34. Brochiero E, Dagenais A, Prive A, Berthiaume Y, Grygorczyk R: Evidence of a functional CFTR Cl-channel in adult alveolar epithelial cells. Am J Physiol Lung Cell Molec Physiol 2004;287:L382-L392.
35. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA: Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 2002;119:199-207.
36. Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, Kass D, Martino JM, Bellmeyer A, Albazi JS, Emala C, Lee HT, Dobbs LG, Matalon S: Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 2007;104:4083-4088.
37. Nielsen V G, Duvall MD, Baird MS, Matalon S: cAMP activation of chloride and fluid secretion across the rabbit alveolar epithelium. Am J Physiol Lung Cell Molec Physiol 1998;19:L1127-L1133.
38. Widdcombe JH: How does cAMP increase active Na absorption across alveolar epithelium? Am J Physiol Lung Cell Molec Physiol 2000;278:L231-L232.
39. Kleyman TR, Zuckerman JB, Middleton P, McNulty KA, Hu BF, Su XF, An B, Eaton DC, Smith PR: Cell surface expression and turnover of the alpha-subunit of the epithelial sodium channel. Am J Physiol 2001;281:F213-F221.
40. Ito Y, Niisato N, O'Brodovich H, Marunaka Y: The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium. Pflügers Arch Eur J Physiol 1997;434:492-494.
41. + -ATPase activity by membrane insertion of a-subunits in lung alveolar cells. Am J Physiol Lung Cell Molec Physiol 1999;20:L20-L27.
42. Minakata Y, Suzuki S, Grygorczyk C, Dagenais A, Berthiaume Y: Impact of beta-adrenergic agonist on Na+ channel and Na+-K+-ATPase expression in alveolar type II cells. Am J Physiol 1998;275:L414-L422.
43. Strosberg AD: Structure, function, and regulation of adrenergic receptors. Protein Sci 1993;2:1198-1209.
44. Mairbäurl H, Wodopia R, Eckes S, Schulz S, Bärtsch P: Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol 1997;273:L797-L806.
45. Wodopia R, Ko HS, Billian J, Wiesner R, Bärtsch P, Mairbäurl H: Hypoxia decreases proteins involved in transepithelial electrolyte transport of A549 cells and rat lung. Am J Physiol 2000;279:L1110-L1119.
46. Krick S, Eul BG, Hanze J, Savai R, Grimminger F, Seeger W, Rose F: Role of hypoxia-inducible factor-1 alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells. Amer J Respir Cell Molec Biol 2005;32:395-403.