Comparison of adaboost and support vector machines for detecting alzheimer's disease through automated hippocampal segmentation

IEEE Transactions on Medical Imaging

Volumn 29, Issue 1, 2010, Pages 30-43

  Morra, Jonathan H ^a   Tu, Zhuowen ^a   Apostolova, Liana G ^a   Green, Amity E ^a   Toga, Arthur W ^a   Thompson, Paul M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AdaBoost; Alzheimer's disease; Hippocampal segmentation; Support vector machines (SVMs); Surface modeling

Indexed keywords

ADABOOST; ALZHEIMER'S DISEASE; AUTOMATED FEATURES; AUTOMATED METHODS; BRAIN MRI; BRAIN SEGMENTATION; COGNITIVE IMPAIRMENT; FALSE DISCOVERY RATE; FEATURE SELECTION; GOLD STANDARDS; INDEPENDENT SET; MACHINE LEARNING ALGORITHMS; MANUAL SEGMENTATION; PARAMETRIC SURFACES; SEGMENTATION ACCURACY; SHAPE DIFFERENCE; SIGNIFICANCE MAPS; SURFACE MODELING; TRAINING AND TESTING; TRAINING SETS;

ADA (PROGRAMMING LANGUAGE); ADAPTIVE BOOSTING; AUTOMATION; DIAGNOSIS; THREE DIMENSIONAL; VECTORS;

SUPPORT VECTOR MACHINES;

ALGORITHM; ALZHEIMER DISEASE; ARTICLE; ARTIFICIAL INTELLIGENCE; BAYES THEOREM; HIPPOCAMPUS; HUMAN; IMAGE PROCESSING; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY;

ALGORITHMS; ALZHEIMER DISEASE; ARTIFICIAL INTELLIGENCE; BAYES THEOREM; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING;

EID: 73849088741     PISSN: 02780062     EISSN: None     Source Type: Journal    
DOI: 10.1109/TMI.2009.2021941     Document Type: Article

References (72)

1. L. Apostolova, I. Dinov, R. Dutton, K. Hayashi, A. Toga, J. Cum-mings, and P. Thompson, "3-D comparison of hippocampal atrophy in amnestic mild cognitive impairmentand Alzheimer's disease, " Brain, pp. 2867-2873, Oct. 2006.
2. L. Apostolova, R. Dutton, I. Dinov, K. Hayashi, A. Toga, J. Cum-mings, and P. Thompson, "Conversion of mild cognitive impairment to Alzheimer's disease is predicted by hippocampal atrophy maps, " Arch. Neurol., vol. 63, pp. 693-699, May 2006.
3. R. Bansal, L. Staib, D. Xu, H. Zhu, and B. Petersen, "Statistical analyses of brain surfaces using Gaussian random fields on 2-D manifolds, " IEEE Trans. Med. Imag., vol. 26, no. 1, pp. 46-57, Jan. 2007.
4. C. Bearden, J. Soares, A. Klunder, M. Nicoletti, N. Diershke, K. Hayashi, P. Brambilla, R. Sassi, D. Axelson, N. Ryan, B. Birmaher, and P. Thompson, "Three-dimensional mapping of hippocampal anatomy in early-onset bipolar disorder, "J. Amer. Acad. Child Ado-lesc. Psych., vol. 47, pp. 515-525, May 2008.
5. C. Bearden, P. Thompson, R. Dutton, B. Frey, M. Peluso, M. Nico-letti, N. Diershke, K. Hayashi, A. Klunder, D. Glahn, P. Brambilla, R. Sassi, A. Mallinger, and J. Soares, "Three-dimensional mapping of hippocampal anatomy inunmedicatedand lithium-treated patients with bipolar disorder, " Neuropsychopharmacology, vol. 33, pp. 1229-1238, Aug. 2007.
6. J. Becker et al., "3-D patterns of hippocampal atrophy in mild cognitive impairment, " Arch. Neurol., vol. 63, no. 1, pp. 97-101, Jan. 2006.
7. Y. Benjamini and Y. Hochberg, "Controlling the false discovery rate: a practicaland powerful approach to multiple testing, "J.R. Statist. Soc. B, vol. 57, no. 1, pp. 289-300, 1995.
8. H. Blum, "A transformation for extracting new descriptors of shape, " in Models for the Perception of Speechand Visual Form, W. Wathen-Dunn, Ed. Cambridge, MA: MIT Press, 1967, pp. 362-380.
9. P. Bradley and O. Mangasarian, "Feature selection via concave minimizationand support vector machines, " in Proc. 15th Int. Conf. Mach. Learn., 1998, pp. 82-90.
10. C. Burges, "A tutorial on support vector machines for pattern recognition, " Data Mining Knowledge Disc., vol. 2, pp. 121-167, 1998. (Pubitemid 128695475)
11. Y. Chou, N. Leporé, G. de Zubicaray, O. Carmichael, J. Becker, A. Toga, and P. Thompson, "Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease, " NeuroImage, vol. 40, pp. 615-630, Jul. 2007.
12. L. Clare, R. Woods, E.M. Cook, M. Orrell, and A. Spector, "Cognitive rehabilitationand cognitive training for early-stage Alzheimer's diseaseand vascular dementia, " Cochrane Database Syst. Rev., vol. 4, 2003.
13. D. Collins, P. Neelin, T.M. Peters, and A.C. Evans, "Automatic 3-D in-tersubject registration of MR volumetric data in standardized talairach space, "J. Comput. Assist. Tomogr., vol. 18, pp. 192-205, 1994.
14. E. Edgington and P. Onghena, Randomization Tests. New York: Marcel Dekker, 1986.
15. Y. Fan, D. Shen, and C. Davatzikos, "Classification of structural images via high-dimensional image warping, robust feature extraction, and SVM, " in Proc. MICCAI, 2005.
16. B. Fischl et al., "Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain, " Neurotechnique, vol. 33, pp. 341-355, 2002.
17. Y. Freund and R. Schapire, "A decision-theoretic generalization of on-line learningand an application to boosting, "J. Comput. Syst. Sci., vol. 55, pp. 119-139, 1997.
18. G. Frisoni, F. Sabattoli, A. Lee, R. Dutton, A. Toga, and P. Thompson, "In vivo neuropathology of the hippocampal formation in AD: A radial mapping MR-based study, " NeuroImage, vol. 32, no. 1, pp. 104-110, Aug. 2006.
19. D. Galasko, M. Klauber, C. Hofstetter, D. Salmon, B. Lasker, and L. Thal, "The mini-mental state examination in the early diagnosis of Alzheimer's disease, " Arch. Neurol., vol. 47, no. 1, pp. 49-52, Jan. 1990.
20. C. Genovese, N. Lazar, and T. Nichols, "Thresholding of statistical maps in functional neuroimaging using the false discovery rate, " Neuro Image, vol. 15, no. 4, pp. 870-878, 2002.
21. N. Gogtay, T. Nugent, D. Herman, A. Ordonez, D. Greenstein, K. Hayashi, L. Classen, A. Toga, J. Giedd, J. Rapoport, and P. Thompson, "Dynamic mapping of normal human hippocampal development, " Hippocampus, pp. 664-672, 2006.
22. P. Golland, W. Grimson, M. Shenton, and R. Kikinis, "Detectionand analysis of statistical differences in anatomical shape, " Med. Imag. Anal., vol. 9, no. 1, pp. 69-86, 2005.
23. B. Gutman, Y. Wang, L. Lui, T. Chang, and P. Thompson, "Hip-pocampal surface analysis using spherical harmonic functions applied to surface conformal mapping, " in Proc. Int. Conf. Pattern Recognit., 2006, pp. 964-967.
24. A. Hammers, R. Heckemann, M. Koepp, J. Duncan, J. Hajnal, D. Rueckert, and P. Aljabar, "Automatic detectionand quantification of hippocampal atrophy on MRI in temporal lobe epilepsy: A proof of principle study, " Neuro Image, vol. 36, pp. 38-47, May 2007.
25. R. Hogan, K. Mark, L. Wang, S. Joshi, M. Miller, and R. Bucholz, "Mesial temporal sclerosisand temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients, " Radiology, vol. 216, pp. 291-297, 2000. (Pubitemid 30434758)
26. C. Jack et al., "The Alzheimer's disease neuroimaging initiative (ADNI): The MR imaging protocol, "J. MRI, vol. 27, no. 4, pp. 685-691, 2008.
27. T. Joachims, "Training linear SVMs in linear time, " in Proc. ACM Conf. Knowledge Discovery Data Mining (KDD), 2006, pp. 217-226.
28. S. LaConte, S. Strother, V. Cherkassky, J. Anderson, and X. Hu, "Support vector machines for temporal classification of block design fMRI data, " Neuro Image, vol. 26, no. 2, pp. 317-329, Jun. 2005.
29. D. Langers, J. Jansen, and W. Backes, "Enhanced signal detection in neuroimagingby meansofregional controlofthe global false discovery rate, " Neuro Image, vol. 38, pp. 45-56, Oct. 2007.
30. Z. Lao, D. Shen, A. Jawad, B. Karacali, D. Liu, E. Melhem, N. Bryan, and C. Davatzikos, "Automated segmentation of white matter lesions in 3-D brain mr images, using multivariate pattern classification, " in Proc. 3rd IEEE Int. Symp. Biomed. Imag. (ISBI), Arlington, VA, Apr. 2006, pp. 307-310.
31. N. Leporé, C. Brun, Y. Chou, M. Chiang, R. Dutton, K. Hayashi, A. Lu, O. Lopez, H. Aizenstein, A. Toga, J. Becker, and P. Thompson, "Generalized tensor-based morphometry of HIV/AIDS using multivariate statistics on deformation tensors, " IEEE Trans. Med. Imag., vol. 27, no. 1, pp. 129-141, Jan. 2008.
32. J. Lin, N. Salamon, A. Lee, R. Dutton, J. Geaga, K. Hayashi, A. Toga, J. Engel, and P. Thompson, "3-D pre-operative maps of hippocampal atophy predict surgical outcomes in temporal lobe epilepsy, " Neurology, vol. 65, pp. 1094-1097, Oct. 2005.
33. S. Loncaric, "A survey of shape analysis techniques-From automata to hardware, " Pattern Recognit., vol. 31, no. 8, pp. 983-1001, Aug. 1998.
34. N. Lord, J. Ho, B. Vemuri, and S. Eisenschenk, "Simultaneous registrationand parcellation of bilateral hippocampal surface pairs for local asymmetry quantification, " IEEE Trans Med. Imag., vol. 26, no. 4, pp. 471-1178, Apr. 2007.
35. J. Luts, A. Heerschap, J. Suykens, and S.V. Huffel, "A combined MRIand MRSI based multiclass system for brain tumor recognition using LS-SVMS with class probabilitiesand feature selection, " Artif. Intell. Med., vol. 40, no. 2, pp. 87-102, Jun. 2007.
36. J. Mazziotta, A. Toga, A. Evans, P. Fox, J. Lancaster, K. Zilles, R. Woods, T. Paus, G. Simpson, B. Pike, C. Holmes, D. Collins, P. Thompson, D. MacDonald, T. Schormann, K. Amunts, N. Palomero-Gallagher, L. Parsons, K. Narr, N. Kabani, G.L. Goualher, D. Boomsma, T. Cannon, R. Kawashima, and B. Mazoyer, "A probabilistic atlasand reference system for the human brain, "J.R. Statist. Soc. B, vol. 356, no. 1412, pp. 1293-1322, Jan. 2001.
37. M. Miller, "Computational anatomy: shape, growthand atrophy comparison via diffeomorphisms, " Neuro Image, vol. 23, no. 1, pp. 19-33, 2004.
38. J. Morra, Z. Tu, L. Apostolova, A. Green, C. Avedissian, S. Madsen, X. Hua, A.T.C. Jack, M. Weiner, and P. Thompson, "Validation of a fully automated 3d hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls, " Neuro Image, vol. 43, no. 1, pp. 59-68, Oct. 2008.
39. K. Müller, M. Sebastian, G. Rätsch, T. Koji, and B. Schölkopf, "An introduction to kernel-based learning, " IEEE Trans. Neural Networks, vol. 12, pp. 181-201, Mar. 2001.
40. K. Narr, T. v. Erp, T. Cannon, R. Woods, P. Thompson, S. Jang, R. Blanton, V. Poutanen, M. Huttunen, J. Lonnqvist, C. Standerksjold-Nordenstam, J. Kaprio, J. Mazziotta, and A. Toga, "A twin study of genetic contributions to hippocampal morphology in schizophrenia, " Neurobiol. Disease, vol. 11, no. 1, pp. 83-95, Oct. 2002. (Pubitemid 35435676)
41. T. Nichols and A. Holmes, "Nonparametric permutation tests for functional neuroimaging: a primer with examples, " Human Brain Mapp., vol. 15, no. 1, pp. 1-25, 2002.
42. R. Nicolson, T. DeVito, C. Vidal, Y. Sui, K. Hayashi, D. Drost, P. Williamson, N. Rajakumar, A. Toga, and P. Thompson, "Detectionand mapping of hippocampal abnormalities in autism, " Psych. Neuroimag. Res., vol. 148, no. 1, pp. 11-21, Nov. 2006.
43. T. Nugent, D. Herman, A. Ordonez, D. Greenstein, K. Hayashi, M. Lenane, L. Clasen, D. Jung, A. Toga, J. Giedd, J. Rapoport, P. Thompson, and N. Gogtay, "Dynamic mapping of hippocampal development in childhood onset schizophrenia, " Schizophrenia Res., vol. 90, pp. 62-70, Feb. 2007.
44. K. Pohl, J. Fisher, R. Kikinis, W. Grimson, and W. Wells, "A Bayesian model for joint segmentationand registration, " Neuro Image, vol. 31, no. 1, pp. 228-239, 2006.
45. K. Pohl, J. Fisher, M. Shenton, R. McCarley, W. Grimson, R. Kikinis, and W. Wells, "Logarithm odds maps for shape representation, " in Proc. MICCAI, 2006, vol. 6, pp. 955-963.
46. S. Powell, V. Magnotta, H. Johnson, V. Jammalamadaka, R. Pierson, and N. Andreasen, "Registrationand machine learning based automated segmentation of subcorticaland cerebellar brain structures, " Neuro Image, vol. 39, no. 1, pp. 238-247, Jan. 2008.
47. A. Quddus, P. Fieguth, and O. Basir, "Adaboostand support vector machines for white matter lesion segmentation in MR images, " Proc. 27th IEEE Eng. Med. Biol. Soc., pp. 463-466, 2005.
48. D. Rex, J. Ma, and A. Toga, "The LONI pipeline processing environment, " Neuro Image, vol. 19, no. 3, pp. 1033-1048, Jul. 2003.
49. F. Sabattoli, M. Boccardi, S. Galluzzi, A. Treves, P. Thompson, and G. Frisoni, "Hippocampal shape differences in dementia with Lewy bodies, " Neuro Image, vol. 41, no. 3, pp. 699-705, Jul. 2008.
50. R. Schapire, Y. Freund, P. Bartlett, and W. Lee, "Boosting the margin: A new explanation for the effectiveness of voting methods, " Ann. Statist., vol. 26, no. 5, pp. 1651-1686, 1998.
51. D. Shattuck, S. Sandor-Leahy, K. Schaper, D. Rottenberg, and R. Leahy, "Magnetic resonance image tissue classification using a partial volume model, " Neuro Image, vol. 13, pp. 856-876, 2001.
52. D. Shen, S. Moffat, S. Resnick, and C. Davatzikos, "Measuring sizeand shape of the hippocampus in MR images using a deformable shape model, " Neuro Image, vol. 15, no. 2, pp. 422-434, Feb. 2002.
53. Y. Shi, A. Bobick, and I. Essa, A Bayesian view of boostingand its extensions, ser. GVU Tech. Rep. GIT-GVU-05-22. Atlanta, GA: Georgia Inst. Technol., 2005.
54. Y. Shi, P. Thompson, G. de Zubicaray, S. Rose, Z. Tu, I. Dinov, and A. Toga, "Direct mapping of hippocampal surfaces with intrinsic shape context, " Neuro Image, pp. 792-807, Sep. 2007.
55. J. Storey, "A direct approach to false discovery rates, "J.R. Statist. Soc. B, vol. 64, no. 3, pp. 479-498, 2002.
56. M. Styner, J. Lieberman, and G. Gerig, "Boundaryand medial shape analysis of the hippocampus in schizophrenia, " in Proc. MICCAI, Feb. 2003, pp. 464-471.
57. T. Terriberry, J. Damon, S. Pizer, S. Joshi, and G. Gerig, "Population-based fitting of medial shape models with correspondence optimization, " Inf. Process. Med. Imag., vol. 20, pp. 700-712, 2007.
58. P. Thompson, K. Hayashi, G. de Zubicaray, A. Janke, S. Rose, J. Semple, D. Herman, M. Hong, S. Dittmer, D. Doddrell, and A. Toga, "Dynamics of gray matter loss in Alzheimer's disease, "J. Neurosci., vol. 23, no. 3, pp. 994-1005, Feb. 2003.
59. P. Thompson, K. Hayashi, G. de Zubicaray, A. Janke, S. Rose, J. Semple, M. Hong, D. Herman, D. Gravano, D. Doddrell, and A. Toga, "Mapping hippocampaland ventricular change in Alzheimer's disease, " Neuro Image, vol. 22, no. 4, pp. 1754-1766, Aug. 2004.
60. P. Thompson, K. Hayashi, S. Simon, J. Geaga, M. Hong, Y. Sui, J. Lee, A. Toga, W. Ling, and E. London, "Structural abnormalities in the brains of human subjects who use methamphetamine, "J. Neurosci., vol. 24, no. 26, pp. 6028-6036, Jun. 2004.
61. P. Thompson, C. Schwartz, R. Lin, A. Khan, and A. Toga, "3-D statistical analysis of sulcal variability in the human brain, "J. Neurosci., vol. 16, no. 13, pp. 4261-4274, Jul. 1996.
62. P. Thompson, C. Schwartz, and A. Toga, "High-resolution random mesh algorithms for creating a probabilistic 3-D surface atlas of the human brain, " Neuro Image, vol. 3, no. 1, pp. 19-34, Mar. 1996.
63. D. Tschumperlé, Cimg Library 2007 [Online]. Available: http://cimg. sourceforge. net/.
64. Z. Tu, "Probabilistic boosting tree: Learning discriminative models for classification, recognition, and clustering, " in Proc. ICCV, 2005.
65. Z. Tu, K. Narr, P. Dollar, I. Dinov, P. Thompson, and A. Toga, "Brain anatomical structure segmentation by hybrid discriminative/ generative models, " IEEE Trans. Med. Imag., vol. 27, no. 4, pp. 495-508, Apr. 2008.
66. M. Valliant and J. Glaunès, "Surface matching via currents, " Inf. Process. Med. Imag., vol. 19, pp. 381-392, 2005.
67. V. Vapnik, Statistical Learning Theory. New York: Wiley, 1998.
68. L. Wang, F. Beg, T. Ratnanather, C. Ceritoglu, L. Younse, J. Morris, J. Csernansky, and M. Miller, "Large deformation diffeomorphismand momentum based hippocampal shape discrimination in dementia of the Alzheimer type, " IEEE Trans. Med. Imag., vol. 26, no. 4, pp. 462-470, Apr. 2007.
69. Y. Wang, M. Chiang, and P. Thompson, "Mutual information-based 3-D surface matching with applications to face recognitionand brain mapping, " in Proc. Int. Conf. Comput. Vis., Beijing, China, Oct. 2005, pp. 527-534.
70. P. Yushkevich, S. Joshi, S. Pizer, J. Csernansky, and L. Wang, "Feature selection for shape-based classification of biological objects, " Inform. Process. Med. Imag., pp. 114-125, Aug. 2003.
71. P.A. Yushkevich, J. Piven, C. Hazlett, H. Smith, G. Smith, R. Ho, S. Ho, J. Gee, and G. Gerig, "User-guided 3-D active contour segmentation of anatomical structures: Significantly improved efficiencyand reliability, " Neuro Image, vol. 31, pp. 1116-1128, 2006.
72. M. Zeineh, S. Engel, P. Thompson, and S. Bookheimer, "Dynamics of the hippocampus during encodingand retrieval of face-name pairs, " Science, vol. 299, no. 5606, pp. 577-580, Jan. 2003