Effectiveness and tolerability of zonisamide in children with epilepsy: A retrospective review

Seizure

Volumn 19, Issue 1, 2010, Pages 31-35

  Tan, Hui Jeen ^a   Martland, Timothy R ^a   Appleton, Richard E ^b   Kneen, Rachel ^b  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Children; Clinical experience; Intractable epilepsy; Retrospective review; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALLERGIC RASH; ANOREXIA; ARTICLE; CHILD; COGNITIVE DEFECT; CONTROLLED STUDY; DIARRHEA; DRESS SYNDROME; DROWSINESS; DRUG EFFICACY; DRUG TOLERABILITY; EPILEPSY; FATIGUE; FEMALE; FOCAL EPILEPSY; FOLLOW UP; GENERALIZED EPILEPSY; HUMAN; LETHARGY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MENTAL INSTABILITY; MORBIDITY; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOSIS; RASH; RESPIRATORY TRACT DISEASE; RETROSPECTIVE STUDY; SCHOOL CHILD; SEIZURE; SIDE EFFECT; SLEEP DISORDER; SOMNOLENCE; TREATMENT DURATION; UNITED KINGDOM; VISUAL HALLUCINATION; WEIGHT REDUCTION;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG EVALUATION; EPILEPSY; FEMALE; HUMANS; INFANT; ISOXAZOLES; MALE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 73749085925     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2009.10.008     Document Type: Article

References (33)

1. Baulac M. Introduction to zonisamide. Epilepsy Research 68 Suppl. 2 (2006) S3-9
2. Rock D.M., Macdonald R.L., and Taylor C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Research 3 2 (1989) 138-143
3. Kito M., Maehara M., and Watanabe K. Mechanisms of T-type calcium channel blockade by zonisamide. Seizure 5 2 (1996) 115-119
4. Ueda Y., Doi T., Tokumaru J., and Willmore L.J. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Research. Molecular Brain Research 116 1-2 (2003) 1-6
5. Kochak G.M., Page J.G., Buchanan R.A., Peters R., and Padgett C.S. Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures. Journal of Clinical Pharmacology 38 2 (1998) 166-171
6. Levy R.H., Ragueneau-Majlessi I., Garnett W.R., Schmerler M., Rosenfeld W., Shah J., et al. Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. Journal of Clinical Pharmacology 44 11 (2004) 1230-1234
7. Levy R.H., Ragueneau-Majlessi I., Brodie M.J., Smith D.F., Shah J., and Pan W.J. Lack of clinically significant pharmacokinetic interactions between zonisamide and lamotrigine at steady state in patients with epilepsy. Therapeutic Drug Monitoring 27 2 (2005) 193-198
8. Ragueneau-Majlessi I., Levy R.H., Bergen D., Garnett W., Rosenfeld W., Mather G., et al. Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. Epilepsy Research 62 1 (2004) 1-11
9. Ragueneau-Majlessi I., Levy R.H., Brodie M., Smith D., Shah J., and Grundy J.S. Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. Clinical Pharmacokinetics 44 5 (2005) 517-523
10. Glauser T.A., and Pellock J.M. Zonisamide in pediatric epilepsy: review of the Japanese experience. Journal of Child Neurology 17 2 (2002) 87-96
11. Ohtahara S. Zonisamide in the management of epilepsy-Japanese experience. Epilepsy Research 68 Suppl. 2 (2006) S25-33
12. Schmidt D., Jacob R., Loiseau P., Deisenhammer E., Klinger D., Despland A., et al. Zonisamide for add-on treatment of refractory partial epilepsy: a European double-blind trial. Epilepsy Research 15 1 (1993) 67-73
13. Faught E., Ayala R., Montouris G.G., and Leppik I.E. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 57 10 (2001) 1774-1779
14. Sackellares J.C., Ramsay R.E., Wilder B.J., Browne III T.R., and Shellenberger M.K. Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. Epilepsia 45 6 (2004) 610-617
15. Brodie M.J., Duncan R., Vespignani H., Solyom A., Bitenskyy V., and Lucas C. Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. Epilepsia 46 1 (2005) 31-41
16. Santos C.C., and Brotherton T. Use of zonisamide in pediatric patients. Pediatric Neurology 33 1 (2005) 12-14
17. Kim H.L., Aldridge J., and Rho J.M. Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center. Journal of Child Neurology 20 3 (2005) 212-219
18. Mandelbaum D.E., Bunch M., Kugler S.L., Venkatasubramanian A., and Wollack J.B. Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy. Journal of Child Neurology 20 7 (2005) 594-597
19. Kluger G., Zsoter A., and Holthausen H. Long-term use of zonisamide in refractory childhood-onset epilepsy. European Journal of Paediatric Neurology 12 1 (2008) 19-23
20. Coppola G., Grosso S., Verrotti A., Parisi P., Luchetti A., Franzoni E., et al. Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study. Epilepsy Research 83 2-3 (2009) 112-116
21. Shinnar S., Pellock J.M., and Conry J.A. Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. European Journal of Paediatric Neurology 13 1 (2009) 3-9
22. French J.A., Kanner A.M., Bautista J., Abou-Khalil B., Browne T., Harden C.L., et al. Efficacy and tolerability of the new antiepileptic drugs, II: treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 45 5 (2004) 410-423
23. Kothare S.V., Kaleyias J., Mostofi N., Valencia I., Melvin J.J., Hobdell E., et al. Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy. Pediatric Neurology 34 5 (2006) 351-354
24. Wilfong A.A. Zonisamide monotherapy for epilepsy in children and young adults. Pediatric Neurology 32 2 (2005) 77-80
25. Lotze T.E., and Wilfong A.A. Zonisamide treatment for symptomatic infantile spasms. Neurology 62 2 (2004) 296-298
26. Kothare S.V., Valencia I., Khurana D.S., Hardison H., Melvin J.J., and Legido A. Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. Epileptic Disorders 6 4 (2004) 267-270
27. Wilfong A., and Schultz R. Zonisamide for absence seizures. Epilepsy Research 64 1-2 (2005) 31-34
28. You S.J., Kang H.C., Kim H.D., Lee H.S., and Ko T.S. Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience. Brain Development 30 4 (2008) 287-290
29. Oguni H., Hayshi K., Fukuyama Y., Watanabe K., Mimaki T., Ontanara, et al. Phase III clinical study of the new antiepileptic drug AD-810 (zonisamide) in patients with childhood epilepsy. Japanese Journal of Pediatrics 41 (1988) 439-450 [in Japanese]
30. Loscher W., and Schmidt D. Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia 47 8 (2006) 1253-1284
31. Glauser T.A. Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients. Journal of Child Neurology 19 Suppl. 1 (2004) S25-38
32. Miyamoto T., Kohsaka M., and Koyama T. Psychotic episodes during zonisamide treatment. Seizure 9 1 (2000) 65-70
33. Kanner A.M. Can antiepileptic drugs unmask a susceptibility to psychiatric disorders?. Nature Clinical Practice Neurology 5 3 (2009) 132-133