Zonisamide in children and young adults with refractory epilepsy: An open label, multicenter Italian study

Epilepsy Research

Volumn 83, Issue 2-3, 2009, Pages 112-116

  Coppola, Giangennaro ^a   Grosso, Salvatore ^d   Verrotti, Alberto ^e   Parisi, Pasquale ^c   Luchetti, Anna ^c   Franzoni, Emilio ^f   Mangano, Salvatore ^g   Pelliccia, Andrea ^c   Operto, Francesca Felicia ^a   Iannetti, Paola ^c   Curatolo, Paolo ^b   Balestri, Paolo ^d   Pascotto, Antonio ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF SIENA   (Italy)

^e UNIVERSITY OF CHIETI   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g UNIVERSITY OF PALERMO   (Italy)

Author keywords

Antiepileptic drugs; Epilepsy; Pediatric epilepsy; Zonisamide

Indexed keywords

ZONISAMIDE;

ABDOMINAL PAIN; ADD ON THERAPY; ADENOMEGA; ADOLESCENT; ADULT; APPETITE; ARTICLE; ATTENTION DISTURBANCE; BLOOD CHEMISTRY; CHILD; CHOREOATHETOSIS; CLINICAL ASSESSMENT; COMPUTER ASSISTED TOMOGRAPHY; DROWSINESS; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TOLERABILITY; ELECTROENCEPHALOGRAM; EPILEPSY; FEMALE; FOCAL EPILEPSY; FOLLOW UP; GENERALIZED EPILEPSY; HEADACHE; HUMAN; INSOMNIA; IRRITABILITY; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; PRIORITY JOURNAL; REFRACTORY EPILEPSY; SEIZURE SUSCEPTIBILITY; SIDE EFFECT; TREATMENT RESPONSE; VOMITING; WEAKNESS; WEIGHT GAIN;

ADOLESCENT; ADULT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG TOLERANCE; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; ISOXAZOLES; ITALY; MAGNETIC RESONANCE IMAGING; MALE; NEUROLOGIC EXAMINATION; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 58949086626     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2008.10.012     Document Type: Article

References (14)

1. Biton V. Zonisamide: newer antiepileptic agent with multiple mechanisms of action. Expert Rev. Neurother. 4 (2004) 935-943
2. Dravet C., Roger J., and Bureau M. L'epilepsie myoclonicque severe du nourisson. In: Roger J., Dravet C., Bureau M., Dreifuss F.E., and Wolf P. (Eds). Les syndromes épilepticques de l'enfant et de l'adolescent (1984), John Libbey Eurotext Ltd. 58-67
3. Iinuma K., and Haginoya K. Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey. Seizure 13 Suppl 1 (2004) S34-39
4. Commission on classification and terminology of the International League against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 22 (1981) 489-501
5. Kim H.L., Aldridge J., and Rho J.M. Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center. J. Child Neurol. 20 3 (2005) 212-219
6. Kluger G., Zsoter A., and Holthausen H. Long-term use of zonisamide in refractory childhood-onset epilepsy. Eur. J. Paediatr. Neurol. 12 1 (2008) 19-23
7. Kothare S.V., Kaleyias J., Mostofi N., Valencia I., Melvin J.J., Hobdell E., Khurana D.S., and Legido A. Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy. Pediatr. Neurol. 34 5 (2006) 351-354
8. Lotze T.E., and Wilfong A.A. Zonisamide treatment for symptomatic infantile spasms. Neurology 27 2 (2004) 296-298
9. Mandelbaum D.E., Bunch M., Kugler S.L., Venkatasubramanian A., and Wollack J.B. Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy. J. Child Neurol. 20 7 (2005) 594-597
10. Miura H. Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies. Seizure 13 Suppl 1 (2004) S17-23
11. Ohtahara S. Zonisamide in the management of epilepsy-Japanese experience. Epilepsy Res. 68 Suppl 2 (2006) S25-33
12. Santos C.C., and Brotherton T. Use of zonisamide in pediatric patients. Pediatr. Neurol. 33 1 (2005) 12-14
13. Seki T., Kumagai N., and Maezawa M. Effects of zonisamide monotherapy in children with epilepsy. Seizure 13 Suppl 1 (2004) S26-32
14. You S.J., Kang H.C., Kim H.D., Lee H.S., and Ko T.S. Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience. Brain Dev. 22 (2007) [Epub ahead of print]