A new approach to characterise pharmaceutical aerosols: Measurement of aerosol from a single dose aqueous inhaler with an optical particle counter

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 1-3, 2010, Pages 45-52

  Kuhli, Maren ^a   Weiss, Maximilian ^b   Steckel, Hartwig ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b PALAS GMBH   (Germany)

Author keywords

Aerosol particle sizing; Aerosol spectrometer; Cascade impaction; Laser diffraction; Respimat; Spray duration

Indexed keywords

FENOTEROL PLUS IPRATROPIUM BROMIDE;

ACCURACY; AEROSOL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DILUTION; DRUG DELIVERY SYSTEM; EVAPORATION; FLOW RATE; INHALER; INTERMETHOD COMPARISON; LASER DIFFRACTION; NEBULIZER; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SENSOR; SPECTROMETRY; WHITE LIGHT;

ADMINISTRATION, INHALATION; AEROSOLS; BRONCHODILATOR AGENTS; DRUG COMBINATIONS; DRUG DELIVERY SYSTEMS; FENOTEROL; IPRATROPIUM; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHOTOMETRY; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 73749085358     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.10.009     Document Type: Article

References (19)

1. Berg, E., Mitchell, J., Dennis, J., Kreher, C., Jauernig, J., Lamb, P., Karlsson, M., Nikander, K., Tservistas, M., 2007. The Nebuliser Sub-Team of the European Pharmaceutical Aerosol Group (EPAG). Drug Delivery to the Lungs, vol. 18. The Aerosol Society, Bristol, UK.
2. CEN. Comité Européen de Normalisation: European Standard-Respiratory Therapy Equipment. Part 1. Nebulizing Systems and their Components, EN 13544-1 (2001)
3. Copley M. A new regulatory approach in nebuliser testing. Pharma Magazine January/February (2008) 46-47
4. Copley M., Smurthwaite M., Roberts D.L., and Mitchell J.P. Revised internal volumes of cascade impactors for those provided by Mitchell and Nagel. Journal of Aerosol Medicine and Pulmonary Drug Delivery 18 (2005) 364-366
5. de Boer A.H., Gjaltema D., Hagedoorn P., Schaller M., Witt W., and Frijlink H.W. Design and application of a new modular adapter for laser diffraction characterization of inhalation aerosols. International Journal of Pharmaceutics 249 (2002) 233-245
6. Hochrainer D., Holz H., Kreher C., Scaffidi L., Spallek M., and Wachtel H. Comparison of the aerosol velocity and spray duration of Respimat Soft Mist inhaler and pressurized metered dose inhalers. Journal of Aerosol Medicine and Pulmonary Drug Delivery 18 (2005) 273-282
7. Hubrath, T., Kumb, J., 2008. Comparison of two methods to prevent evaporation of aqueous droplets in Andersen Cascade Impactor. Drug Delivery to the Lungs. Edinburgh, UK.
8. Kuhli M., Weiss M., and Steckel H. A sampling and dilution system for droplet aerosols from medical nebulisers developed for use with an optical particle counter. Journal of Aerosol Science 40 (2009) 523-533
9. Kuhli M., Weiss M., and und Steckel H. Size matters: a method comparison for aqueous drug suspensions for nebulization. Respiratory Drug Delivery Europe 2 (2009) 285-288
10. Marple V.A., Olson B.A., Santhanakrishnan K., Roberts D.L., Mitchell J.P., and und Hudson-Curtis B.L. Next generation pharmaceutical impactor: a new impactor for pharmaceutical inhaler testing. Part III. Extension of archival calibration to 15 L/min. Journal of Aerosol Medicine and Pulmonary Drug Delivery 17 (2004) 335-343
11. Mitchell J.P., Nagel M.W., Nichols S., and und Nerbrink O. Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers. Journal of Aerosol Medicine and Pulmonary Drug Delivery 19 (2006) 409-433
12. Moelter L. Hochaufgelöste Einzelpartikelgrößenbestimmung. GIT Labor-Fachzeitschrift 43 (1999) 364-366
13. Moelter L. Online Überwachung einer Strahlmühle mit optischen Aerosolspektrometern. Symposium Produktgestaltung in der Partikeltechnologie. Pfinztal, Fraunhofer IRB-Verlag, Stuttgart (2006)
14. Moelter L., and und Kessler P. Grundlagen der Partikelgrößen- und Partikelanzahlbestimmung in der Außenluft mit zählenden Messverfahren. Gefahrstoffe - Reinhaltung der Luft 64 (2004) 319-323
15. Ph. Eur. Zubereitungen zur Inhalation: Aerodynamische Beurteilung feiner Teilchen (2.9.18). Europäisches Arzneibuch 6.0, amtliche deutsche Ausgabe (2008)
16. Wachtel H., and Ziegler J. Improved assessment of inhaler device performance using laser diffraction. Respiratory Drug Delivery VIII (2002), Tucson, Arizona
17. Weiss C. Datenanalyse und Modellierung mit Statistica (2007), Oldenbourg Wissenschaftsverlag GmbH, München
18. Willeke K., and Baron P.A. Aerosol Measurement-Principles, Techniques and Applications (1993), Van Nostrand Reinhold, New York
19. Ziegler J., and Wachtel H. Comparison of cascade impaction and laser diffraction for particle size distribution measurements. Journal of Aerosol Medicine and Pulmonary Drug Delivery 18 (2005) 311-324