A sampling and dilution system for droplet aerosols from medical nebulisers developed for use with an optical particle counter

Journal of Aerosol Science

Volumn 40, Issue 6, 2009, Pages 523-533

  Kuhli, Maren ^a   Weiss, Maximilian ^b   Steckel, Hartwig ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b PALAS GMBH   (Germany)

Author keywords

Cascade impaction; Humidity conditioning; Laser diffraction; Light scattering aerosol spectrometer; Nebuliser

Indexed keywords

DIFFRACTION; DROPS; LASER THEORY; LIGHT SCATTERING; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; SPECTROMETERS;

AEROSOL SPECTROMETERS; EUROPEAN PHARMACOPOEIAS; LASER DIFFRACTIONS; MEASUREMENT TECHNIQUES; MEASURING SYSTEMS; NEBULISER; OPTICAL PARTICLE COUNTERS; PHARMACEUTICAL INDUSTRY;

AEROSOLS;

AIR CONDITIONING; AIR SAMPLING; DIFFRACTION; DILUTION; DRUG; HUMIDITY; LIGHT SCATTERING; MIE THEORY; PARTICLE SIZE; PERFORMANCE ASSESSMENT; QUALITY CONTROL; SIZE DISTRIBUTION; SPECTROMETER;

AEROSOL; AIR SAMPLING; ARTICLE; DILUTION; LASER DIFFRACTION; NEBULIZER; PARTICLE SIZE; PERFORMANCE; PRIORITY JOURNAL; QUALITY CONTROL; SPECTROMETER;

CENTRAL EUROPE; EURASIA; EUROPE; GERMANY;

BUTEA MONOSPERMA;

EID: 67349278789     PISSN: 00218502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2009.02.007     Document Type: Article

References (24)

1. Berg, E., et al. (2007). The nebuliser sub-team of the European Pharmaceutical Aerosol Group (EPAG). Drug Delivery to the Lungs 18, Edinburgh, UK, pp. 71-74.
2. CEN. (2001). Comité Européen de Normalisation: European Standard-respiratory therapy equipment-part 1: Nebulizing systems and their components. EN 13544-1.
3. Copley M. Nebulizer testing. Inhalation 2 (2008) 31-34
4. Copley M. A new regulatory approach in nebuliser testing. Pharm. Mag. (2008) 46-47 Jan/Feb
5. Copley M., et al. Revised internal volumes of cascade impactors for those provided by Mitchell and Nagel. J. Aerosol Med. 18 (2005) 364-366
6. de Boer A.H., et al. Characterization of inhalation aerosols: A critical evaluation of cascade impactor analysis and laser diffraction technique. Int. J. Pharm. 249 (2002) 219-231
7. de Boer A.H., et al. Design and application of a new modular adapter for laser diffraction characterization of inhalation aerosols. Int. J. Pharm. 249 (2002) 233-245
8. Dunbar C., and Mitchell J. Analysis of cascade impactor mass distributions. J. Aerosol Med. 18 (2005) 439-451
9. Friehmelt R. Aerosol-Messsysteme-Vergleichbarkeit und Kombination ausgewählter online Verfahren. Fachbereich Maschinenbau und Verfahrenstechnik (1999), Universität Kaiserslautern, Kaiserslautern
10. Hardaker, L. E., et al. (2008). Is evaporation the only process that affects aerosol particle size characterization with a next generation impactor in ambient and cooled states. Respiratory Drug Delivery 2008 (pp. 727-730), Scottsdale, Arizona.
11. Helsper C. Probleme der Staubprobenahme bei der Filterprüfung. F & S-Filtrieren & Separieren 95 (1995)
12. Marple V.A., et al. Next generation pharmaceutical impactor (a new impactor for pharmaceutical inhaler testing). Part II: Archival calibration. J. Aerosol Med. 16 (2003) 301-324
13. Marple V.A., et al. Next generation pharmaceutical impactor (a new impactor for pharmaceutical inhaler testing). Part I: Design. J. Aerosol Med. 16 (2003) 283-299
14. Marple V.A., et al. Next generation pharmaceutical impactor: A new impactor for pharmaceutical inhaler testing. Part III. Extension of archival calibration to 15 L/min. J. Aerosol Med. 17 (2004) 335-343
15. Merkus H.G., et al. Droplet size distribution measurements for medical nebulizers by the forward light scattering technique ("laser diffraction"). J. Aerosol Sci. 25 (1994) S319-S320
16. Mitchell J.P., and Nagel M.W. Cascade impactors for the size characterization of aerosols from medical inhalers: Their uses and limitations. J. Aerosol Med. 16 (2003) 341-377
17. Mitchell J.P., et al. Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers. J. Aerosol Med. 19 (2006) 409-433
18. Moelter L. Hochaufgelöste Einzelpartikelgrößenbestimmung. GIT Labor-Fachzeitschrift 43 (1999) 364-366
19. Moelter, L. (2006). Online Überwachung einer Strahlmühle mit optischen Aerosolspektrometern. Symposium Produktgestaltung in der Partikeltechnologie (Vol. 3, pp. 347-362), Fraunhofer IRB-Verlag, Stuttgart, Pfinztal.
20. Moelter L., and Kessler P. Grundlagen der Partikelgrößen- und Partikelanzahlbestimmung in der Außenluft mit zählenden Messverfahren. Gefahrstoffe-Reinhaltung der Luft 64 (2004) 319-323
21. Roy G., and Tessier P. Particle-size distributions obtained from diffraction patterns-contribution of refraction and reflection. J. Aerosol Sci. 21 (1990) 515-526
22. Seemann, S. & Weinstein, L. (2006). Satisfying CDRH ans FDA's 510(k) demands for device reliability with a complex electromechanical device: eFLOW. Respiratory Drug Delivery 2006, Boca Raton, Florida, pp. 279-285.
23. Wachtel, H. & Ziegler, J. (2002). Improved assessment of inhaler device Performance using laser diffraction. Respiratory Drug Delivery VIII (Vol. 2, pp. 379-382), Tucson, Arizona.
24. Willeke K., and Baron P.A. Aerosol measurement-principles, techniques and applications (1993), Van Nostrand Reinhold, New York