On the dynamic modeling of mammalian cell metabolism and mAb production

Computers and Chemical Engineering

Volumn 34, Issue 2, 2010, Pages 210-222

  Baughman, Adam C ^a,b   Huang, Xinqun ^a   Sharfstein, Susan T ^a,b   Martin, Lealon L ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Bioprocess development; Kinetics; Metabolism; Monoclonal antibodies; Optimization; Pharmaceuticals

Indexed keywords

ALGEBRAIC EQUATIONS; BIOPROCESS DEVELOPMENT; BIOPROCESSES; CELL METABOLISM; CONTINUOUS DIFFERENTIAL EQUATIONS; DISCRETIZATIONS; DISCRETIZED EQUATIONS; DYNAMIC MODELING; EXPERIMENTAL MEASUREMENTS; MAMMALIAN CELL CULTURE; MAMMALIAN CELLS; METABOLIC MODELING; MODEL PARAMETERS; NON-LINEAR OPTIMIZATION PROBLEMS; OBSERVED SYSTEMS; OPTIMAL SETS; OPTIMIZATION-BASED TECHNIQUES; ORIGINAL MODEL;

ANIMAL CELL CULTURE; CELL CULTURE; DIFFERENTIAL EQUATIONS; DYNAMIC MODELS; MAMMALS; MONOCLONAL ANTIBODIES; OPTIMIZATION; PARAMETER ESTIMATION; SURFACE PLASMON RESONANCE;

METABOLISM;

EID: 73749085128     PISSN: 00981354     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compchemeng.2009.06.019     Document Type: Article

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