Neurotrophin receptors trkA and trkB in retinoblastoma are differentially expressed depending on cellular differentiation

Tumor Biology

Volumn 30, Issue 5-6, 2009, Pages 233-241

  Kim, Jeong Hun ^a   Kim, Jin Hyoung ^a   Kim, Dong Hun ^b   Cho, Chang Sik ^a   Jun, Hyoung Oh ^a   Yu, Young Suk ^a   Kim, Kyu Won ^c  

^a Seoul National University College of Medicine   (South Korea)

^b Soonchunhyang University College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Differentiation; Extracellular signal regulated kinase; Retinoblastoma; TrkA; TrkB

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILDHOOD CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RETINOBLASTOMA;

EID: 73749083341     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000243766     Document Type: Article

References (30)

1. Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 689: 820-823.
2. Lee WH, Murphree AL, Benedict WF: Expression and amplification of the N- myc gene in primary retinoblastoma. Nature 1984; 309: 458-460.
3. Squire J, Goddard AD, Canton M, Becker A, Phillips RA, Gallie BL: Tumour induction by the retinoblastoma mutation is independent of N- myc expression. Nature 1986; 322: 555-557.
4. Lillington DM, Goff LK, Kingston JE, Onadim Z, Price E, Domizio P, Young BD: High level amplification of N- myc is not associated with adverse histology or outcome in primary retinoblastoma tumours. Br J Cancer 2002; 87: 779-782.
5. Kim JH, Choi JM, Yu YS, Kim DH, Kim JH, Kim KW: N- myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma. Hum Pathol 2008; 39: 1172-1175.
6. Kim JH, Kim JH, Yu YS, Kim DH, Min BH, Kim KW: Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. Int J Oncol 2007; 31: 585-592.
7. Kopelman JE, McLean IW, Rosenberg SH: Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation. Ophthalmology 1987; 94: 371-377.
8. Shields CL, Shields JA, Baez KA, Cater J, De Potter PV: Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors. Br J Ophthalmol 1993; 77: 544-548.
9. Shields CL, Shields JA, Baez KA, Cater JR, De Potter P: Optic nerve invasion of retinoblastoma: metastatic potential and clinical risk factors. Cancer 1994; 73; 692-698.
10. Khelfaoui F, Validire P, Auperin A, Quintana E, Michon J, Pacquement H, Desjardins L, Asselain B, Schlienger P, Vielh P: Histopathologic risk factors in retinoblastoma: a retrospective study of 172 patients treated in a single institution, Cancer 1996; 77: 1206-1213.
11. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA: Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444: 61-66.
12. Chen D, Livne-Bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R: Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death resistant cell-of-origin in retinoblastoma. Cancer Cell 2004; 5: 539-551.
13. Johnson DA, Zhang J, Frase S, Wilson M, Rodriguez-Galindo C, Dyer MA: Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res 2007; 67: 2701-2711.
14. Barbacid M: Neurotrophic factors and their receptors. Curr Opin Cell Biol 1995; 7: 148-155.
15. Verdi JM, Birren SJ, Ibáñez CF, Persson H, Kaplan DR, Benedetti M, Chao MV, Anderson DJ: p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 1994; 12: 733-745.
16. Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Azar CG, Cantor AB, Brodeur GM: Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med 1993; 328: 847-854.
17. Hoehner JC, Olsen L, Sandstedt B, Kaplan DR, Påhlman S: Association of neurotrophin receptor expression and differentiation in human neuroblastoma. Am J Pathol 1995; 147: 102-111.
18. Krüttgen A, Schneider I, Weis J: The dark side of the NGF family: neurotrophins in neoplasias. Brain Pathol 2006; 16: 304-310.
19. Lavenius E, Gestblom C, Johansson I, Nånberg E, Påhlman S: Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor. Cell Growth Differ 1995; 6: 727-736.
20. Matsumoto K, Wada RK, Yamashiro JM, Kaplan DR, Thiele CJ: Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells. Cancer Res 1995; 55: 1798-1806.
21. Ho R, Eggert A, Hishiki T, Minturn JE, Ikegaki N, Foster P, Camoratto AM, Evans AE, Brodeur GM: Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res 2002; 62: 6462-6466.
22. Kimura N, Nakamura M, Kimura I, Nagura H: Tissue localization of nerve growth factor receptors: Trk A and low-affinity nerve growth factor receptor in neuroblastoma, pheochromocytoma, and retinoblastoma. Endocr Pathol 1996; 7: 281-289.
23. Wagner N, Wagner KD, Sefton M, Rodríguez-Tébar A, Grantyn R: An abnormal response of retinoblastoma cells (Y-79) to neurotrophins. Invest Ophthalmol Vis Sci 2000; 41: 1932-1939.
24. Stephan H, Zakrzewski JL, Bölöni R, Grasemann C, Lohmann DR, Eggert A: Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. Pediatr Blood Cancer 2008; 50: 218-222.
25. Kim JH, Kim JH, Yu YS, Kim DH, Min BH, Kim KW: Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma. Oncol Rep 2007; 18: 1373-1377.
26. Nag TC, Wadhwa S: Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina. Brain Res Dev Brain Res 1999; 117: 179-189.
27. Lachyankar MB, Condon PJ, Daou MC, De AK, Levine JB, Obermeier A, Ross AH: Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. J Neurosci Res 2003; 71: 157-172.
28. Eggert A, Ikegaki N, Liu X, Chou TT, Lee VM, Trojanowski JQ, Brodeur GM: Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells. Oncogene 2000; 19: 2043-2051.
29. Clagett-Dame M, McNeill EM, Muley PD: The role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J Neurobiol 2006; 66: 739-756.
30. Kampmann E, Mey J: Retinoic acid enhances ERK phosphorylation in the chick retina. Neurosci Lett 2007; 426: 18-22.