Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors

Toxicology

Volumn 268, Issue 1-2, 2010, Pages 19-24

  Gu, Ying ^a   Ting, Zhang ^a   Qiu, Xi ^a   Zhang, Xuzhao ^a   Gan, Xiaoxian ^b   Fang, Yongming ^a   Xu, Xiaohua ^a   Xu, Rongzhen ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Apoptosis; Cyclin dependent kinase inhibitor; Leukemia; Linalool; p53 tumor suppressor

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45ALPHA; LINALOOL; PROTEIN C JUN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG INDICATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; HUMANS; MONOTERPENES; PROTEIN KINASE INHIBITORS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 73749083303     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.11.013     Document Type: Article

References (24)

1. Barnes D.J., and Melo J.V. Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia. Cell Cycle 5 (2006) 2862-2866
2. Bueso-Ramos C., Xu Y., McDonnell T.J., Brisbay S., Pierce S., Kantarjian H., Rosner G., and Garcia-Manero G. Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. J. Clin. Oncol. 23 (2005) 3932-3939
3. Cecchinato V., Chiaramonte R., Nizzardo M., Cristofaro B., Basile A., Sherbet G.V., and Comi P. Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem. Pharmacol. 74 (2007) 1568-1574
4. Chen Q., Xie W., Kuhn D.J., Voorhees P.M., Lopez-Girona A., Mendy D., Corral L.G., Krenitsky V.P., Xu W., Moutouh-de Parseval L., Webb D.R., Mercurio F., Nakayama K.I., Nakayama K., and Orlowski R.Z. Targeting the p27 E3 ligase SCF (Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111 (2008) 4690-4699
5. Chiang L.C., Chiang W., Chang M.Y., Ng L.T., and Lin C.C. Antileukemic activity of selected natural products in Taiwan. Am. J. Chin. Med. 31 (2003) 37-46
6. el-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., and Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 75 (1993) 817-825
7. Guzman M.L., Swiderski C.F., Howard D.S., Grimes B.A., Rossi R.M., Szilvassy S.J., and Jordan C.T. Preferential induction of apoptosis for primary human leukemic stem cells. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 16220-16225
8. Guzman M.L., Rossi R.M., Karnischky L., Li X., Peterson D.R., Howard D.S., and Jordan C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105 (2005) 4163-4169
9. Holtz M.S., Forman S.J., and Bhatia R. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia 19 (2005) 1034-1041
10. Holyoake T., Jiang X., Eaves C., and Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 94 (1999) 2056-2064
11. Loizzo M.R., Tundis R., Menichini F., Saab A.M., Statti G.A., and Menichini F. Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Cell Prolif. 41 (2008) 1002-1012
12. Kastan M.B., Zhan Q., el-Deiry W.S., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., and Fornace Jr. A.J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71 (1992) 587-597
13. Mantena S.K., Sharma S.D., and Katiyar S.K. Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 27 (2006) 2018-2027
14. Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Liebermann D.A., Hoffman B., and Reed J.C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 (1994) 1799-1805
15. Olagnier D., Costes P., Berry A., Linas M.D., Urrutigoity M., Dechy-Cabaret O., and Benoit-Vical F. Modifications of the chemical structure of terpenes in antiplasmodial and antifungal drug research. Bioorg. Med. Chem. Lett. 17 (2007) 6075-6078
16. Paik S.Y., Koh K.H., Beak S.M., Paek S.H., and Kim J.A. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biol. Pharm. Bull. 28 (2005) 802-807
17. Ravizza R., Gariboldi M.B., Molteni R., and Monti E. Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. Oncol. Rep. 20 (2008) 625-630
18. Renouf B., Hollville E., Pujals A., Tétaud C., Garibal J., and Wiels J. Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells. Leukemia 23 (2009) 1557-1563
19. Tovar C., Rosinski J., Filipovic Z., Higgins B., Kolinsky K., Hilton H., Zhao X., Vu B.T., Qing W., Packman K., Myklebost O., Heimbrook D.C., and Vassilev L.T. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 1888-1893
20. Usta J., Kreydiyyeh S., Knio K., Barnabe P., Bou-Moughlabay Y., and Dagher S. Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels. Chem. Biol. Interact. 180 (2009) 39-46
21. Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammlott U., Lukacs C., Klein C., Fotouhi N., and Liu E.A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
22. Xu R., Yu Y., Zheng S., Zhao X., Dong Q., He Z., Liang Y., Lu Q., Fang Y., Gan X., Xu X., Zhang S., Dong Q., Zhang X., and Feng G.S. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood 106 (2005) 3142-3149
23. Xu R., Dong Q., Yu Y., Zhao X., Gan X., Wu D., Lu Q., Xu X., and Yu X.F. Berbamine: a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity. Leuk. Res. 30 (2006) 17-23
24. Xu R., Zhang X., Zhang W., Fang Y., Zheng S., and Yu X.F. Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma. Hepatology 46 (2007) 1810-1820