Ki-67 expression in non-tumour epithelium adjacent to oral cancer as risk marker for multiple oral tumours

Oral Diseases

Volumn 16, Issue 1, 2010, Pages 68-75

  Gonzalez Moles M A ^a   Bravo, M ^a   Ruiz Avila I ^b   Acebal, F ^c   Gil Montoya, J A ^a   Brener, S ^d   Esteban, F ^e  

^a UNIVERSITY OF GRANADA   (Spain)

^b Pathology Department   (Spain)

^c Neurotraumatological Hospital   (Spain)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Ki 67; Oral cancer; Premalignant field; Proliferation; Second tumour

Indexed keywords

KI 67 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER GRADING; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; MOUTH MUCOSA; MOUTH TUMOR; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; EPITHELIUM; FEMALE; HUMANS; KI-67 ANTIGEN; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASMS, SECOND PRIMARY; PRECANCEROUS CONDITIONS; ROC CURVE; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL;

EID: 73649140239     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2009.01611.x     Document Type: Article

References (25)

1. Abbas NF, Labib El-Sharkawy S, Abbas EA, Abdel Monem El-Shaer M (2007). Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 : 385 390.
2. Barnes L, Eveson JW, Reichart PA, Sidransky D (2005). World health organization classification of tumours. Pathology and genetics. Head and neck tumours. World Health Organization : Lyon.
3. Braakhuis BJM, Tabor MP, Leemans CR, Van Der Waal I, Snow GB, Brakenhoff RH (2002). Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions. Head Neck 24 : 198 206.
4. Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH (2003). A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63 : 1727 1730.
5. Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC (2006). Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Dis 12 : 443 454.
6. Fan GK, Chen J, Ping F, Geng Y (2006). Immunohistochemical analysis of P57 (kip2), p53 and hsp60 expressions in premalignant and malignant oral tissues. Oral Oncol 42 : 147 153.
7. Gat U, DasGupta R, Degenstein L, Fuchs E (1998). De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95 : 605 614.
8. Gonzalez-Moles MA, Ruiz-Avila I, Rodriguez-Archilla A, Martinez-Lara I (2000). Suprabasal expression of Ki-67 antigen as a marker for the presence and severity of oral epithelial dysplasia. Head Neck 22 : 658 661.
9. Hanley JA, McNeil BJ (1982). The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143 : 29.
10. Hashibe M, Ritz B, Le AD, Li G, Sankaranarayanan R, Zhang ZF (2005). Radiotherapy for oral cancer as a risk factor for second primary cancers. Cancer Lett 220 : 185 195.
11. Hong WK, Lippman SM, Itri LM et al (1990). Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 1990 : 323.
12. van Houten VMM, Tabor MP, van den Brekel MWM et al (2002). Mutated P53 as molecular marker for the diagnosis of head and neck cancer. J Pathol 198 : 476 486.
13. Johnson N, Franceschi S, Ferlay J et al 2005) Squamous cell carcinoma. In : Barnes L, Eveson JW, Reichart P, Sidransky D, eds. Pathology and genetics. Head and neck tumours. Lyon : IARC Press, pp. 168 175.
14. Macluskey M, Chandrachud LM, Pazouki S et al (2000). Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. J Pathol 191 : 368 375.
15. Mao L, Lee JS, Fan YH et al (1996). Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nat Med 2 : 682 685.
16. Partridge M, Pateromichelakis S, Phillips E, Emilion GG, A'Hern RP, Langdon JD (2000). A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization. Cancer Res 60 : 3893 3898.
17. Perez-Losada J, Balmain A (2003). Stem-cell hierarchy in skin cancer. Nat Rev Cancer 3 : 434 443.
18. Rosin MP, Cheng X, Poh C et al (2000). Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res 6 : 357 362.
19. Tabor MP, Brakenhoff RH, van Houten VM et al (2001). Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res 7 : 1523 1532.
20. Tabor MP, Brakenhoff RH, Ruijter-Schippers HJ et al (2002). Multiple head and neck tumors frequently originate from a single preneoplastic lesion. Am J Pathol 161 : 1051 1060.
21. Tabor MP, Braakhuis BJM, van der Wal JE et al (2003). Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx. J Pathol 199 : 354 360.
22. Takeda T, Sugihara K, Hirayama Y, Hirano M, Tanuma JI, Semba I (2006). Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med 35 : 369 375.
23. Woolgar JA (2006). Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol 42 : 229 239.
24. Youden WJ (1952). Index for rating diagnostic tests. Cancer 3 : 32.
25. Zhu AJ, Watt FM (1999). Beta-cathenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126 : 2285 2298.