메뉴 건너뛰기




Volumn 10, Issue 12, 2009, Pages 1929-1939

Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent

Author keywords

Candidate gene; Cholesterol; Endocannabinoid; Insulin resistance; Metabolic syndrome

Indexed keywords

FATTY ACID AMIDASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; TRIACYLGLYCEROL;

EID: 73649131984     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.122     Document Type: Article
Times cited : (28)

References (53)
  • 1
    • 53849092685 scopus 로고    scopus 로고
    • Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic
    • Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK: Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 16, 2323-2330 (2008).
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2323-2330
    • Wang, Y.1    Beydoun, M.A.2    Liang, L.3    Caballero, B.4    Kumanyika, S.K.5
  • 2
    • 4444382796 scopus 로고    scopus 로고
    • Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study
    • Yusuf S, Hawken S, Ounpuu S et al.: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364, 937-952 (2004).
    • (2004) Lancet , vol.364 , pp. 937-952
    • Yusuf, S.1    Hawken, S.2    Ounpuu, S.3
  • 3
    • 14344273991 scopus 로고    scopus 로고
    • Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
    • Kissebah AH, Sonnenberg GE, Myklebust J et al.: Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl Acad. Sci. USA 97, 14478-14483 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 14478-14483
    • Kissebah, A.H.1    Sonnenberg, G.E.2    Myklebust, J.3
  • 4
    • 25144450879 scopus 로고    scopus 로고
    • Clinical practice. Low HDL cholesterol levels
    • Ashen MD, Blumenthal RS: Clinical practice. Low HDL cholesterol levels. N. Engl. J. Med. 353, 1252-1260 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1252-1260
    • Ashen, M.D.1    Blumenthal, R.S.2
  • 5
    • 61749097782 scopus 로고    scopus 로고
    • Use of cannabinoid CB1 receptor antagonists for the treatment of metabolic disorders
    • Scheen AJ, Paquot N: Use of cannabinoid CB1 receptor antagonists for the treatment of metabolic disorders. Best Pract. Res. Clin. Endocrinol. Metab. 23, 103-116 (2009).
    • (2009) Best Pract. Res. Clin. Endocrinol. Metab , vol.23 , pp. 103-116
    • Scheen, A.J.1    Paquot, N.2
  • 6
    • 0036669295 scopus 로고    scopus 로고
    • Tetrahydrocannabinol and endocannabinoids in feeding and appetite
    • Berry EM, Mechoulam R: Tetrahydrocannabinol and endocannabinoids in feeding and appetite. Pharmacol. Ther. 95, 185-190 (2002).
    • (2002) Pharmacol. Ther , vol.95 , pp. 185-190
    • Berry, E.M.1    Mechoulam, R.2
  • 8
    • 45749158085 scopus 로고    scopus 로고
    • Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
    • Benzinou M, Chèvre JC, Ward KJ et al.: Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Hum. Mol. Genet. 17, 1916-1921 (2008).
    • (2008) Hum. Mol. Genet , vol.17 , pp. 1916-1921
    • Benzinou, M.1    Chèvre, J.C.2    Ward, K.J.3
  • 9
    • 34347273447 scopus 로고    scopus 로고
    • Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men
    • Russo P, Strazzullo P, Cappuccio FP et al.: Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. J. Clin. Endocrinol. Metab. 92, 2382-2386 (2007).
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 2382-2386
    • Russo, P.1    Strazzullo, P.2    Cappuccio, F.P.3
  • 10
    • 34249671248 scopus 로고    scopus 로고
    • Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population
    • Gazzerro P, Caruso MG, Notarnicola M et al.: Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population. Int. J. Obes. 31, 908-912 (2007).
    • (2007) Int. J. Obes , vol.31 , pp. 908-912
    • Gazzerro, P.1    Caruso, M.G.2    Notarnicola, M.3
  • 11
    • 35348858145 scopus 로고    scopus 로고
    • The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men
    • Peeters A, Beckers S, Mertens I, van Hul W, van Gaal L: The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. Endocrine 31, 138-141 (2007).
    • (2007) Endocrine , vol.31 , pp. 138-141
    • Peeters, A.1    Beckers, S.2    Mertens, I.3    van Hul, W.4    van Gaal, L.5
  • 12
    • 61549101858 scopus 로고    scopus 로고
    • Baye TM, Zhang Y, Smith E et al.: Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics 9, 1647-1656 (2008). Prior work showing that genetic variation in endocannabinoid signaling directly affects lipids.
    • Baye TM, Zhang Y, Smith E et al.: Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics 9, 1647-1656 (2008). Prior work showing that genetic variation in endocannabinoid signaling directly affects lipids.
  • 13
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt BF, Demarest K, Patricelli MP et al.: Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl Acad. Sci. USA 98, 9371-9376 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1    Demarest, K.2    Patricelli, M.P.3
  • 14
    • 35348851360 scopus 로고    scopus 로고
    • Studies of anandamide accumulation inhibitors in cerebellar granule neurons: Comparison to inhibition of fatty acid amide hydrolase
    • Hillard CJ, Shi L, Tuniki VR, Falck JR, Campbell WB: Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. J. Mol. Neurosci. 33, 18-24 (2007).
    • (2007) J. Mol. Neurosci , vol.33 , pp. 18-24
    • Hillard, C.J.1    Shi, L.2    Tuniki, V.R.3    Falck, J.R.4    Campbell, W.B.5
  • 16
    • 17844411014 scopus 로고    scopus 로고
    • Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
    • Sipe JC, Waalen J, Gerber A, Beutler E: Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Int. J. Obes. (Lond.) 29, 755-759 (2005).
    • (2005) Int. J. Obes. (Lond.) , vol.29 , pp. 755-759
    • Sipe, J.C.1    Waalen, J.2    Gerber, A.3    Beutler, E.4
  • 17
    • 34247874502 scopus 로고    scopus 로고
    • The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
    • Jensen DP, Andreasen CH, Andersen MK et al.: The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites. J. Mol. Med. 85, 445-449 (2007).
    • (2007) J. Mol. Med , vol.85 , pp. 445-449
    • Jensen, D.P.1    Andreasen, C.H.2    Andersen, M.K.3
  • 18
    • 63049107495 scopus 로고    scopus 로고
    • Variants in the CNR1 and the FAAH genes and adiposity traits in the community
    • Recent work showing that genetic variation in endocannabinoid signaling does not influence BMI longitudinally
    • Lieb W, Manning AK, Florez JC et al.: Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity 17, 755-760 (2009). Recent work showing that genetic variation in endocannabinoid signaling does not influence BMI longitudinally.
    • (2009) Obesity , vol.17 , pp. 755-760
    • Lieb, W.1    Manning, A.K.2    Florez, J.C.3
  • 19
    • 73649092288 scopus 로고    scopus 로고
    • Evaluating the association of FAAH common gene variation with childhood, adult severe obesity, and type 2 diabetes in the French population
    • Durand E, Lecoeur C, Delplanque J et al.: Evaluating the association of FAAH common gene variation with childhood, adult severe obesity, and type 2 diabetes in the French population. Obesity Facts 1, 305-309 (2008).
    • (2008) Obesity Facts , vol.1 , pp. 305-309
    • Durand, E.1    Lecoeur, C.2    Delplanque, J.3
  • 20
    • 34250002798 scopus 로고    scopus 로고
    • Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet
    • Aberle J, Fedderwitz I, Klages N, George E, Beil FU: Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet. Horm. Metab. Res. 39, 395-397 (2007).
    • (2007) Horm. Metab. Res , vol.39 , pp. 395-397
    • Aberle, J.1    Fedderwitz, I.2    Klages, N.3    George, E.4    Beil, F.U.5
  • 21
    • 17944362243 scopus 로고    scopus 로고
    • The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    • Comuzzie AG, Funahashi T, Sonnenberg G et al.: The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab. 86, 4321-4325 (2001).
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 4321-4325
    • Comuzzie, A.G.1    Funahashi, T.2    Sonnenberg, G.3
  • 22
    • 27644490692 scopus 로고    scopus 로고
    • Genetic variation in selenoprotein S influences inflammatory response
    • Curran JE, Jowett JB, Elliott KS et al.: Genetic variation in selenoprotein S influences inflammatory response. Nat. Genet. 37, 1234-1241 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 1234-1241
    • Curran, J.E.1    Jowett, J.B.2    Elliott, K.S.3
  • 23
    • 2342648224 scopus 로고    scopus 로고
    • Major quantitative trait locus for resting heart rate maps to a region on chromosome 4
    • Martin LJ, Comuzzie AG, Sonnenberg GE et al.: Major quantitative trait locus for resting heart rate maps to a region on chromosome 4. Hypertension 43, 1146-1151 (2004).
    • (2004) Hypertension , vol.43 , pp. 1146-1151
    • Martin, L.J.1    Comuzzie, A.G.2    Sonnenberg, G.E.3
  • 24
    • 33748690296 scopus 로고    scopus 로고
    • Smith EM, Wang X, Littrell J et al.: Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent. Genomics 88, 407-414 (2006). Prior work showing that the linkage structure in our study population is similar to the Centre d'Etude du Polymorphisme Humain (CEPH) population.
    • Smith EM, Wang X, Littrell J et al.: Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent. Genomics 88, 407-414 (2006). Prior work showing that the linkage structure in our study population is similar to the Centre d'Etude du Polymorphisme Humain (CEPH) population.
  • 25
    • 2942698938 scopus 로고    scopus 로고
    • A novel pathway to the manifestations of metabolic syndrome
    • Sonnenberg GE, Krakower GR, Kissebah AH: A novel pathway to the manifestations of metabolic syndrome. Obes. Res. 12, 180-186 (2004).
    • (2004) Obes. Res , vol.12 , pp. 180-186
    • Sonnenberg, G.E.1    Krakower, G.R.2    Kissebah, A.H.3
  • 26
    • 20144388541 scopus 로고    scopus 로고
    • The mitochondrial rhomboid protease PSARL is a new candidate gene for Type 2 diabetes
    • Walder K, Kerr-Bayles L, Civitarese A et al.: The mitochondrial rhomboid protease PSARL is a new candidate gene for Type 2 diabetes. Diabetologia 48, 459-468 (2005).
    • (2005) Diabetologia , vol.48 , pp. 459-468
    • Walder, K.1    Kerr-Bayles, L.2    Civitarese, A.3
  • 28
    • 0022797049 scopus 로고
    • MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test
    • Pacini G, Bergman RN: MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput. Methods Programs Biomed. 23, 113-122 (1986).
    • (1986) Comput. Methods Programs Biomed , vol.23 , pp. 113-122
    • Pacini, G.1    Bergman, R.N.2
  • 29
    • 0028049031 scopus 로고
    • A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study
    • Saad MF, Anderson RL, Laws A et al.: A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study. Diabetes 43, 1114-1121 (1994).
    • (1994) Diabetes , vol.43 , pp. 1114-1121
    • Saad, M.F.1    Anderson, R.L.2    Laws, A.3
  • 30
    • 17344388503 scopus 로고    scopus 로고
    • Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: The Insulin Resistance Atherosclerosis Study
    • Haffner SM, Howard G, Mayer E et al.: Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes 46, 63-69 (1997).
    • (1997) Diabetes , vol.46 , pp. 63-69
    • Haffner, S.M.1    Howard, G.2    Mayer, E.3
  • 31
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International Consortium
    • International Consortium: A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 32
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • International Consortium
    • International Consortium: A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007).
    • (2007) Nature , vol.449 , pp. 851-861
  • 33
    • 38949093567 scopus 로고    scopus 로고
    • Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays
    • Smith EM, Littrell J, Olivier M: Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays. Genomics Proteomics Bioinformatics 5, 256-259 (2007).
    • (2007) Genomics Proteomics Bioinformatics , vol.5 , pp. 256-259
    • Smith, E.M.1    Littrell, J.2    Olivier, M.3
  • 34
    • 18544365991 scopus 로고    scopus 로고
    • Segregation at three loci explains familial and population risk in Hirschsprung disease
    • Gabriel SB, Salomon R, Pelet A et al.: Segregation at three loci explains familial and population risk in Hirschsprung disease. Nat. Genet. 31, 89-93 (2002).
    • (2002) Nat. Genet , vol.31 , pp. 89-93
    • Gabriel, S.B.1    Salomon, R.2    Pelet, A.3
  • 35
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 36
    • 0037098634 scopus 로고    scopus 로고
    • High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology
    • Olivier M, Chuang LM, Chang MS et al.: High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology. Nucleic Acids Res. 30(12), E53 (2002).
    • (2002) Nucleic Acids Res , vol.30 , Issue.12
    • Olivier, M.1    Chuang, L.M.2    Chang, M.S.3
  • 37
    • 17044373944 scopus 로고    scopus 로고
    • The Invader assay for SNP genotyping
    • Olivier M: The Invader assay for SNP genotyping. Mutat. Res. 573(1-2), 103-110 (2005).
    • (2005) Mutat. Res , vol.573 , Issue.1-2 , pp. 103-110
    • Olivier, M.1
  • 38
    • 0030843960 scopus 로고    scopus 로고
    • Genetic and environmental factors in relative body weight and human adiposity
    • Maes HM, Neale MC, Eaves LJ: Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27, 325-351 (1997).
    • (1997) Behav. Genet , vol.27 , pp. 325-351
    • Maes, H.M.1    Neale, M.C.2    Eaves, L.J.3
  • 39
    • 9144231442 scopus 로고    scopus 로고
    • Sex differences in heritability of BMI: A comparative study of results from twin studies in eight countries
    • Schousboe K, Willemsen G, Kyvik KO et al.: Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res. 6, 409-421 (2003).
    • (2003) Twin Res , vol.6 , pp. 409-421
    • Schousboe, K.1    Willemsen, G.2    Kyvik, K.O.3
  • 40
    • 0037062436 scopus 로고    scopus 로고
    • A missense mutation in human fatty acid amide hydrolase associated with problem drug use
    • Sipe JC, Chiang K, Gerber AL, Beutler E, Cravatt BF: A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc. Natl Acad. Sci. USA 99, 8394-8399 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8394-8399
    • Sipe, J.C.1    Chiang, K.2    Gerber, A.L.3    Beutler, E.4    Cravatt, B.F.5
  • 41
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A et al.: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 42
    • 1242294480 scopus 로고    scopus 로고
    • Molecular characterization of a phospholipase D generating anandamide and its congeners
    • Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N: Molecular characterization of a phospholipase D generating anandamide and its congeners. J. Biol. Chem. 279, 5298-5305 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 5298-5305
    • Okamoto, Y.1    Morishita, J.2    Tsuboi, K.3    Tonai, T.4    Ueda, N.5
  • 44
    • 0038738350 scopus 로고    scopus 로고
    • Comparative analysis of fatty acid amide hydrolase and CB(1) cannabinoid receptor expression in the mouse brain: Evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling
    • Egertova M, Cravatt BF, Elphick MR: Comparative analysis of fatty acid amide hydrolase and CB(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience 119, 481-496 (2003).
    • (2003) Neuroscience , vol.119 , pp. 481-496
    • Egertova, M.1    Cravatt, B.F.2    Elphick, M.R.3
  • 45
    • 3242751838 scopus 로고    scopus 로고
    • Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala
    • Gulyas AI, Cravatt BF, Bracey MH et al.: Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur. J. Neurosci. 20, 441-458 (2004).
    • (2004) Eur. J. Neurosci , vol.20 , pp. 441-458
    • Gulyas, A.I.1    Cravatt, B.F.2    Bracey, M.H.3
  • 46
    • 0032476070 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry
    • Tsou K, Nogueron MI, Muthian S et al.: Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neurosci. Lett. 254, 137-140 (1998).
    • (1998) Neurosci. Lett , vol.254 , pp. 137-140
    • Tsou, K.1    Nogueron, M.I.2    Muthian, S.3
  • 47
    • 0038545287 scopus 로고    scopus 로고
    • Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase
    • Clement AB, Hawkins EG, Lichtman AH, Cravatt BF: Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. J. Neurosci. 23, 3916-3923 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 3916-3923
    • Clement, A.B.1    Hawkins, E.G.2    Lichtman, A.H.3    Cravatt, B.F.4
  • 48
    • 0032541111 scopus 로고    scopus 로고
    • Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
    • Colombo G, Agabio R, Diaz G, Lobina C, Reali R, Gessa GL: Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 63, PL113-PL117 (1998).
    • (1998) Life Sci , vol.63
    • Colombo, G.1    Agabio, R.2    Diaz, G.3    Lobina, C.4    Reali, R.5    Gessa, G.L.6
  • 49
    • 35449002089 scopus 로고    scopus 로고
    • Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals
    • Murdolo G, Kempf K, Hammarstedt A, Herder C, Smith U, Jansson PA: Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals. J. Endocrinol. Invest. 30, RC17-RC21 (2007).
    • (2007) J. Endocrinol. Invest , vol.30
    • Murdolo, G.1    Kempf, K.2    Hammarstedt, A.3    Herder, C.4    Smith, U.5    Jansson, P.A.6
  • 50
    • 24644500204 scopus 로고    scopus 로고
    • The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance
    • Jbilo O, Ravinet-Trillou C, Arnone M et al.: The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J. 19, 1567-1569 (2005).
    • (2005) FASEB J , vol.19 , pp. 1567-1569
    • Jbilo, O.1    Ravinet-Trillou, C.2    Arnone, M.3
  • 51
    • 33744986319 scopus 로고    scopus 로고
    • Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin
    • Perwitz N, Fasshauer M, Klein J: Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin. Horm. Metab. Res. 38, 356-358 (2006).
    • (2006) Horm. Metab. Res , vol.38 , pp. 356-358
    • Perwitz, N.1    Fasshauer, M.2    Klein, J.3
  • 52
    • 77951927411 scopus 로고    scopus 로고
    • The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes
    • Epub ahead of print
    • Jia JJ, Tian YB, Cao ZH et al.: The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol. Biol. Rep. (2009) (Epub ahead of print).
    • (2009) Mol. Biol. Rep
    • Jia, J.J.1    Tian, Y.B.2    Cao, Z.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.