Alcadein cleavages by amyloid β-precursor protein (APP) α- and γ-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related γ-secretase dysfunction

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36024-36033

  Hata, Saori ^a   Fujishige, Sayaka ^a   Araki, Yoichi ^a   Kato, Naoko ^a   Araseki, Masahiko ^a   Nishimura, Masaki ^b   Hartmann, Dieter ^c   Saftig, Paul ^d   Fahrenholz, Falk ^e   Taniguchi, Miyako ^f   Urakami, Katsuya ^f   Akatsu, Hiroyasu ^g   Martins, Ralph N ^h   Yamamoto, Kazuo ⁱ   Maeda, Masahiro ^j   Yamamoto, Tohru ^a   Nakaya, Tadashi ^a   Gandy, Sam ^k,l   Suzuki, Toshiharu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

^f TOTTORI UNIVERSITY   (Japan)

^g NAGOYA CITY UNIVERSITY   (Japan)

^h EDITH COWAN UNIVERSITY   (Australia)

ⁱ UNIVERSITY OF TOKYO   (Japan)

^j Immuno Biological Laboratories Co Ltd   (Japan)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^l VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER AMYLOID; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; C-TERMINAL FRAGMENTS; COLOCALIZE; HUMAN CEREBROSPINAL FLUID; KINESINS; MEMBRANE PROTEINS; PRECURSOR PROTEINS; PRESENILINS; PROTEOLYTIC PROCESSING; SECRETASE COMPLEX; SECRETASES;

AMINO ACIDS; BODY FLUIDS; BRAIN; GLYCOPROTEINS; ORGANIC ACIDS; PEPTIDES;

PUMPING PLANTS;

ADAM 17 PROTEIN; ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ALCADEIN; ALCADEIN ALPHA; ALCADEIN BETA; ALCADEIN GAMMA; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; FLAVINE ADENINE NUCLEOTIDE; GAMMA SECRETASE; HYBRID PROTEIN; MEMBRANE PROTEIN; PRESENILIN 1; SHORT PEPTIDE P3 ALCADEIN ALPHA; SHORT PEPTIDE P3 ALCADEIN BETA; SHORT PEPTIDE P3 ALCADEIN GAMMA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME DEFECT; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CALCIUM-BINDING PROTEINS; CELL LINE; HUMANS; MEMBRANE PROTEINS; MICE; PEPTIDES; RECEPTORS, CELL SURFACE;

EID: 73649121986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.057497     Document Type: Article

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