A tolerogenic semimature dendritic cells induce effector T-cell hyporesponsiveness by activation of antigen-specific CD4+CD25+ T regulatory cells that promotes skin allograft survival in mice

Cellular Immunology

Volumn 261, Issue 1, 2010, Pages 69-76

  Fu, Bi mang ^a,b   He, Xiao shun ^a   Yu, Si ^a   Hu, An bin ^a   Zhang, Jie ^b   Ma, Yi ^a   Tam, Nga lei ^a   Huang, Jie fu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Second Affiliated Hospital   (China)

Author keywords

CD4+CD25+ T regulatory cells; Effector T cells; Hyporesponsiveness; Semimature dendritic cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SKIN ALLOGRAFT; SKIN FLAP; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; GRAFT SURVIVAL; HYPERSENSITIVITY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; SKIN; SKIN TRANSPLANTATION; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

MUS;

EID: 73649119853     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.11.003     Document Type: Article

References (26)

1. Rutella S., Danese S., and Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108 (2006) 1435-1440
2. Young J.W., Merad M., and Hart D.N. Dendritic cells in transplantation and immune-based therapies. Biol. Blood Marrow Transplant. 13 (2007) 23-32
3. Bosma B.M., Metselaar H.J., Mancham S., Boor P.P., Kusters J.G., Kazemier G., Tilanus H.W., Kuipers E.J., and Kwekkeboom J. Characterization of human liver dendritic cells in liver grafts and perfusates. Liver Transpl. 12 (2006) 384-393
4. Khanna A., Morelli A.E., Zhong C., Takayama T., Lu L., and Thomson A.W. Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo. J. Immunol. 164 (2000) 1346-1354
5. Sacks J.M., Kuo Y.R., Taieb A., Breitinger J., Nguyen V.T., Thomson A.W., Feili-Hariri M., and Lee W.P. Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression. Plast. Reconstr. Surg. 121 (2008) 37-49
6. Benichou G., Valujskikh A., and Heeger P.S. Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J. Immunol. 162 (1999) 352-358
7. DePaz H.A., Oluwole O.O., Adeyeri A.O., Witkowski P., Jin M.X., Hardy M.A., and Oluwole S.F. Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival. Transplantation 75 (2003) 521-528
8. Lutz M.B., and Schuler G. Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity?. Trends Immunol. 23 (2002) 445-449
9. Verginis P., Li H.S., and Carayanniotis G. Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells. J. Immunol. 174 (2005) 7433-7439
10. van Duivenvoorde D.L., van Mierlo G.J.D., Boonman Z.F., and Toes R.E. Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases. Immunobiology 211 (2006) 627-632
11. Suri R.M., Kukutsch N., Fowler S., Powrie F., and Austyn J. Immature dendritic cells induce alternative CD4(+) T-cell responses in vivo. Transplant. Proc. 33 (2001) 240
12. Morelli A.E., Zahorchak A.F., Larregina A.T., Colvin B.L., Logar A.J., Takayama T., Falo L.D., and Thomson A.W. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood 98 (2001) 1512-1523
13. Akbari O., DeKruyff R.H., and Umetsu D.T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2 (2001) 725-731
14. McGuirk P., McCann C., and Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195 (2002) 221-231
15. Granucci F., Vizzardelli C., Virzi E., Rescigno M., and Ricciardi-Castagnoli P. Transcriptional reprogramming of dendritic cells by differentiation stimuli. Eur. J. Immunol. 31 (2001) 2539-2546
16. Menges M., Rossner S., Voigtlander C., Schindler H., Kukutsch N.A., Bogdan C., Erb K., Schuler G., and Lutz M.B. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J. Exp. Med. 195 (2002) 15-21
17. Braun D., Galibert L., Nakajima T., Saito H., Quang V.V., Rubio M., and Sarfati M. Semimature stage: a checkpoint in a dendritic cell maturation program that allows for functional reversion after signal-regulatory protein-alpha ligation and maturation signals. J. Immunol. 177 (2006) 8550-8559
18. Gangi E., Vasu C., Cheatem D., and Prabhakar B.S. IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J. Immunol. 174 (2005) 7006-7013
19. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., and Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223 (1999) 77-92
20. Billingham R.E., and Medawar P.B. The technique of free skin grafting in mammals. J. Exp. Biol. 28 (1951) 385-402
21. Mayumi H., Nomoto K., and Good R.A. A surgical technique for experimental free skin grafting in mice. Surg. Today 18 (1988) 548-557
22. Zdichavsky M., Jones J.W., Ustuner E.T., Ren X., Edelstein J., Maldonado C., Breidenbach W., Gruber S.A., Ray M., and Barker J.H. Scoring of skin rejection in a swine composite tissue allograft model. J. Surg. Res. 85 (1999) 1-8
23. Kleindienst P., Wiethe C., Lutz M.B., and Brocker T. Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells. J. Immunol. 174 (2005) 3941-3947
24. Lohr J., Knoechel B., Jiang S., Sharpe A.H., and Abbas A.K. The inhibitory function of B 7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol. 4 (2003) 664-669
25. Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., and Bluestone J.A. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12 (2000) 431-440
26. Bayry J., Triebel F., Kaveri S.V., and Tough D.F. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol. 178 (2007) 4184-4193