Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine sensitivity of RGC-5 cells to homocysteine

Current Eye Research

Volumn 35, Issue 1, 2010, Pages 80-90

  Ganapathy, Preethi S ^a   Dun, Ying ^a   Ha, Yonju ^a   Duplantier, Jennifer ^a   Allen, John Bradley ^a   Farooq, Amina ^a   Bozard, B Renee ^a   Smith, Sylvia B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Apoptosis; Excitotoxicity; Hyperhomocysteinemia; Mouse retinal cell line; Neuronal differentiation; Retinal ganglion cells

Indexed keywords

CASPASE 3; HOMOCYSTEINE; STAUROSPORINE; XANTHINE; XANTHINE OXIDASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNODETECTION; NEURITE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIGENS, THY-1; CASPASE 3; CELL DIFFERENTIATION; CELL LINE; GLUTAMIC ACID; HOMOCYSTEINE; HUMANS; IN SITU NICK-END LABELING; OXIDATIVE STRESS; RETINAL GANGLION CELLS; RNA, MESSENGER; STAUROSPORINE; XANTHINE; XANTHINE OXIDASE;

EID: 73649119590     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713680903421194     Document Type: Article

References (45)

1. Wierzbicki AS. Homocysteine and cardiovascular disease: A review of the evidence. Diab Vasc Dis Res 2007;4:143-150.
2. Zhou J, Austin RC. Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms. Biofactors 2009;35:120-129.
3. Obeid R, McCaddon A, Herrmann W. The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Clin Chem Lab Med 2007;45:1590-1606.
4. Martignoni E, Tassorelli C, Nappi G, et al. Homocysteine and Parkinson's disease: A dangerous liaison? J Neurol Sci 2007;257:31-37.
5. Staehelin HB. Micronutrients and Alzheimer's disease. Proc Nutr Soc 2005;64:565-570.
6. Heuberger RA, Fisher AI, Jacques PF, et al. Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2002;76:897-902.
7. Axer-Siegel R, Bourla D, Ehrlich R, et al. Association of neovascular age-related macular degeneration and hyperhomocysteinemia. Am J Ophthalmol 2004;137:84-89.
8. Tsina EK, Marsden DL, Hansen RM, et al. Maculopathy and retinal degeneration in cobalamin C methylmalonic aciduria and homocystinuria. Arch Ophthalmol 2005;123:1143-1146.
9. Seddon JM, Gensler G, Klein ML, et al. Evaluation of plasma homocysteine and risk of age-related macular degeneration. Am J Ophthalmol 2006;141:201-203.
10. Bleich S, Jünemann A, von Ahsen N, et al. Homocysteine and risk of open-angle glaucoma. J Neural Transm. 2002;109:1499-1504.
11. Roedl JB, Bleich S, Reulbach U, et al. Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma. J Neural Transm. 2007;114:445-450.
12. Roedl JB, Bleich S, Reulbach U, et al. Vitamin deficiency and hyperhomocysteinemia in pseudoexfoliation glaucoma. J Neural Transm 2007;114:571-575.
13. Roedl JB, Bleich S, Reulbach U, et al. Homocysteine in tear fluid of patients with pseudoexfoliation glaucoma. J Glaucoma 2007;16:234-239.
14. Clement CI, Goldberg I, Healey PR, et al. Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma. J Glaucoma 2009;18:73-78.
15. Vrabec JP, Levin LA. The neurobiology of cell death in glaucoma. Eye 2007;Suppl 1:S11-S14.
16. Seki M, Lipton SA. Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma. Prog Brain Res 2008;173:495-510.
17. Ganapathy PS, Moister B, Roon P, et al. Endogenous elevation of homocysteine induces retinal ganglion cell death in the cystathionine-β- synthase mutant mouse. Invest Ophthal Vis Sci 2009;50:4460-4470.
18. Goodyear E, Levin LA. Model systems for experimental studies: Retinal ganglion cells in culture. Prog Brain Res 2008;173:279-1184
19. Dun Y, Mysona B, Van Ells TK, et al. Expression of the glutamate- cysteine (xc-) exchanger in cultured retinal ganglion cells and regulation by nitric oxide and oxidative stress. Cell Tiss Res 2006;324:189-202.
20. Dun Y, Thangaraju M, Prasad P, et al. Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1-specific ligand. Invest Ophthamol Vis Sci 2007;48:4785-4794.
21. Umapathy NS, Gnana-Prakasam JP, Martin PM, et al. Cloning and functional characterization of the proton-coupled electrogenic folate transporter from mouse retina and analysis of its expression in retinal cell types. Invest Ophthamol Vis Sci 2007;48:5299-5305.
22. Dun Y, Duplantier JN, Roon P, et al. Serine racemase expression and D-serine content are developmentally regulated in retinal ganglion cells. J Neurochem 2008;104:970-978.
23. Kutty RK, Samuel W, Chen S, et al. Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells. Neurosci Lett 2006;404:294-298.
24. Krishnamoorthy RR, Agarwal P, Prasanna G, et al. Characterization of a transformed rat retinal ganglion cell line. Brain Res Mol Brain Res 2001;86:1-12.
25. Van Bergen NJ, Wood JP, Chidlow G, et al. Re-characterisation of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci 2009;50:4267-4272.
26. Martin PM, Ola MS, Agarwal N, et al. The sigma receptor (oR) ligand (+)-pentazocine prevents retinal ganglion cell death induced in vitro by homocysteine and glutamate. Brain Research Mol Brain Res 2004;123:66-75.
27. Aoun P, Simpkins JW, Agarwal N. Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest Ophthalmol Vis Sci 2003;44, 2999-3004.
28. Fan W, Agarwal N, Kumar MD, et al. Retinal ganglion cell death and neuroprotection: Involvement of the CaMKIIalpha gene. Brain Res Mol Brain Res 2005;139:306-316.
29. Maher P, Hanneken A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line. Invest Ophthalmol Vis Sci 2005; 46:749-757.
30. Frassetto LJ, Schlieve CR, Lieven CJ, et al. Kinase-dependent differentiation of a retinal ganglion cell precursor. Invest Ophthalmol Vis Sci 2006;47:427-438.
31. Lieven CJ, Millet LE, Hoegger MJ, et al. Induction of axon and dendrite formation during early RGC-5 cell differentiation. Exp Eye Res 2007;85:678-683.
32. Tang SS, Zhang JH, Liu HX, et al. Pro-protein convertase-2/ carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia. Neurosci Bull 2009; 25:7-14.
33. Iizuka Y, Hong S, Kim CY, et al. Agmatine pretreatment protects retinal ganglion cells (RGC-5 cell line) from oxidative stress in vitro. Biocell 2008;32:245-250.
34. Harvey R, Chintala SK. Inhibition of plasminogen activators attenuates the death of differentiated retinal ganglion cells and stabilizes their neurite network in vitro. Invest Ophthalmol Vis Sci 2007;48:1884-1891.
35. Moore P, El-Sherbeny A, Roon P, et al. Apoptotic retinal ganglion cell death is induced in vivo by the excitatory amino acid homocysteine. Exp Eye Res 2001; 73:45-57.
36. Graeme JH, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999;354:407-413.
37. Roybal CN, Yang S, Sun CW, et al. Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem 2004;279:14844- 14852.
38. Fourrier MC, Arnold MF, Collet B, et al. The effect of sub- culturing on the basal level of type I interferon (IFN) gene expression in the salmon head kidney (SHK-1) cell line. Fish Shellfish Immunol 2009;27:535-538.
39. Pavan B, Dalpiaz A, Biondi C, et al. An RPE cell line as a useful in vitro model for studying retinoic acid receptor beta: Expression and affinity. Biosci Rep 2008;28:327-334.
40. Youm YH, Kim S, Bahk YY, et al. Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells. BMB Rep 2008;41:722-727.
41. Lan L, Wong NS. Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor. FEBS Lett 1999;444:90-96.
42. Chakravarthy BR, Walker T, Rasquinha I, et al. Activation of DNA-dependent protein kinase may play a role in apoptosis of human nueroblastoma cells. J Neurochem 1999;72:933-942.
43. Harper MM, Adamson L, Blits B, et al. Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxidemediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res 2009;89:538-548.
44. Chen K, Zhang Q, Wang J, et al. Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction. Brain Res 2009;1279:131-138.
45. Kanamori A, Naka M, Fukuda M, et al. Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo. Graefes Arch Clin Exp Ophthalmol 2009;247:1353-1360.