Malaria vaccines: Where next?

PLoS Pathogens

Volumn 5, Issue 10, 2009, Pages

  Holder, Anthony A ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANE ANTIGEN 1; CIRCUMSPOROZOITE PROTEIN; EPITOPE; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 1; MEROZOITE SURFACE PROTEIN 2; PARASITE ANTIGEN;

ANTIGEN SPECIFICITY; ANTIGENIC VARIATION; CELLULAR IMMUNITY; DISEASE MODEL; HOST PARASITE INTERACTION; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL PROCEDURES; INNATE IMMUNITY; LIFE CYCLE; MALARIA; MEROZOITE; MOLECULAR MECHANICS; NONHUMAN; NOTE; PARASITE DEVELOPMENT; ARTICLE; IMMUNOASSAY;

HUMANS; IMMUNOASSAY; MALARIA VACCINES;

EID: 73649111749     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000638     Document Type: Note

References (32)

1. PATH Malaria Vaccine Initiative (27 May 2009) Phase 3 malaria vaccine trial begins-final testing of RTS,S [press release]. Available: http://www. malariavaccine.org/RTSSPhase3-05-27-2009. php. Accessed 7 October 2009.
2. Abdulla S, Oberholzer R, Juma O, Kubhoja S, Machera F, et al. (2008) Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants. N Engl J Med 359: 2533-2544.
3. Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, et al. (2008) Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Med 359: 2521-2532.
4. Vanderberg JP (2009) Reflections on early malaria vaccine studies, the first successful human malaria vaccination, and beyond. Vaccine 27: 2-9.
5. Good MF (2009) The hope but challenge for developing a vaccine that might control malaria. Eur J Immunol 39: 939-943.
6. Sagara I, Dicko A, Ellis RD, Fay MP, Diawara SI, et al. (2009) A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali. Vaccine 27: 3090-3098.
7. Ogutu BR, Apollo OJ, McKinney D, Okoth W, Siangla J, et al. (2009) Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya. PLoS ONE 4: e4708. doi:10.1371/journal.pone.0004708.
8. Wykes M, Good MF (2007) A case for whole-parasite malaria vaccines. Int J Parasitol 37: 705-712.
9. Luke TC, Hoffman SL (2003) Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J Exp Biol 206: 3803-3808.
10. Pinzon-Charry A, Good MF (2008) Malaria vaccines: the case for a whole-organism approach. Expert Opin Biol Ther 8: 441-448.
11. Doolan DL, Dobano C, Baird JK (2009) Acquired immunity to malaria. Clin Microbiol Rev 22: 13-36.
12. Pierce SK, Miller LH (2009) World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not. J Immunol 182: 5171-5177.
13. Roestenberg M, McCall M, Hopman J, Wiersma J, Luty AJ, et al. (2009) Protection against a malaria challenge by sporozoite inoculation. N Engl J Med 361: 468-477.
14. Scherf A, Lopez-Rubio JJ, Riviere L (2008) Antigenic variation in Plasmodium falciparum. Annu Rev Microbiol 62: 445-470.
15. Cortes A, Carret C, Kaneko O, Lim BY, Ivens A, et al. (2007) Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion. PLoS Pathog 3: e107. doi:10.1371/journal. ppat.0030107.
16. Cortes A, Mellombo M, Benet A, Lorry K, Rare L, et al. (2004) Plasmodium falciparum: distribution of msp2 genotypes among symptomatic and asymptomatic individuals from the Wosera region of Papua New Guinea. Exp Parasitol 106: 22-29.
17. Remarque EJ, Faber BW, Kocken CH, Thomas AW (2008) A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits. Infect Immun 76: 2660-2670.
18. Holder AA (2009) The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria. Parasitology 136: 1445-1456.
19. Osier FH, Fegan G, Polley SD, Murungi L, Verra F, et al. (2008) Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. Infect Immun 76: 2240-2248.
20. Doolan DL, Mu Y, Unal B, Sundaresh S, Hirst S, et al. (2008) Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics 8: 4680-4694.
21. Rojas-Galeano S, Hsieh E, Agranoff D, Krishna S, Fernandez-Reyes D (2008) Estimation of relevant variables on high-dimensional biological patterns using iterated weighted kernel functions. PLoS ONE 3: e1806. doi:10.1371/ journal.pone.0001806.
22. Holder AA, Freeman RR (1981) Immunization against blood-stage rodent malaria using purified parasite antigens. Nature 294: 361-364.
23. Coppel RL (2009) Vaccinating with the genome: a Sisyphean task? Trends Parasitol 25: 205-212.
24. Mueller AK, Labaied M, Kappe SH, Matuschewski K (2005) Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433: 164-167.
25. van Schaijk BC, Janse CJ, van Gemert GJ, van Dijk MR, Gego A, et al. (2008) Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes. PLoS ONE 3: e3549. doi:10.1371/journal.pone.0003549.
26. Ting LM, Gissot M, Coppi A, Sinnis P, Kim K (2008) Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity. Nat Med 14: 954-958.
27. Combe A, Giovannini D, Carvalho TG, Spath S, Boisson B, et al. (2009) Clonal conditional mutagenesis in malaria parasites. Cell Host Microbe 5: 386-396.
28. Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, et al. (2009) Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol 7: e84. doi:10.1371/journal.pbio. 1000084.
29. de Koning-Ward TF, O'Donnell RA, Drew DR, Thomson R, Speed TP, et al. (2003) A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies. J Exp Med 198: 869-875.
30. Tewari R, Spaccapelo R, Bistoni F, Holder AA, Crisanti A (2002) Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J Biol Chem 277: 47613-47618.
31. Gruner AC, Mauduit M, Tewari R, Romero JF, Depinay N, et al. (2007) Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS ONE 2: e1371. doi:10.1371/journal.pone.0001371.
32. McIntosh RS, Shi J, Jennings RM, Chappel JC, de Koning-Ward TF, et al. (2007) The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog 3: e72. doi:10.1371/journal.ppat.0030072.