Age-related changes in the expression of 11β-hydroxysteroid dehydrogenase type 2 in rat Leydig cells

Folia Histochemica et Cytobiologica

Volumn 47, Issue 2, 2009, Pages 281-287

  Koeva, Yvetta ^a   Bakalska, Mariana ^b   Atanassova, Nina ^b   Georgieva, Katerina ^a   Davidoff, Michail ^c  

^a MEDICAL UNIVERSITY OF PLOVDIV   (Bulgaria)

^b Institute of Experimental Morphology and Anthropology Bulgarian Academy of Sciences   (Bulgaria)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

11 HSD2; Aging; Leydig cells; Testis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ANDROGEN RECEPTOR; RELAXIN LIKE FACTOR;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOREACTIVITY; LEYDIG CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; STEROIDOGENESIS;

RATTUS;

EID: 73549119748     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-009-0021-3     Document Type: Article

References (42)

1. Hardy M and Schlegel P. Testosterone production in the aging male: Where does the slowdown occur? Endocrinology. 2004;145(10):4439-40.
2. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86:724-31.
3. Wang C, Hikim AS, Ferrini M, et al. Male reproductive aging: using the brown Norway rat as a model for man. Novartis Found Symposium. 2002;242:82-95; discussion 85-87.
4. Chen H, Huhtaniemi I, Zirkin BR. Depletion and repopulation of Leydig cells in the testes in aging Brown Norway rats. Endocrinology. 1996;137:3447-52.
5. Zirkin BR and Chen H. Regulation of Leydig cell steroidogenic function during aging. Biol Reprod. 2000;63:977-81.
6. Chen H, Irizarry RA, Luo L, Zirkin BR. Leydig cell gene expression: effects of age and caloric restriction. Exp Gerontol. 2004;39(1):31-43.
7. Chen H, Hardy MP, Zirkin BR. Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vivo. Endocrinology. 2002;143:1637-1642.
8. Luo L, Chen H, Zirkin BR. Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme. J Androl. 2001;22:149-156.
9. Culty M, Luo L, Yao Z, Chen H, Papadopoulos V, Zirkin B. Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl. 2002;23:439-447.
10. Luo L, Chen H, Zirkin BR. Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging. J Androl. 2005;26(1):25-31.
11. Monder C, Miroff Y, Marandici A, Hardy MP. 11β-dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology. 1994;134:1199-1204.
12. Schultz R, Isola J, Parvinen M, et al. Localization of the glucocorticoid receptor in testis and accessory sexual organs of male rat. Mol Cell Endocrinol. 1993;95:115-20.
13. Ge RS, Hardy DO, Catterall JE, Hardy MP. Developmental changes in glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells. Endocrinology. 1997;138:5089-5095.
14. Gao HB, Ge RS, Lakshmi V, Marandici A, Hardy MP. Hormonal regulation of oxidative and reductive activities of 11βhydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology. 1997;138:156-161.
15. Ge RS, Hardy MP. Initial predominance of the oxidative activity of type I 11β-hydroxysteroid dehydrogenase in primary rat Leydig cells and transfected cell lines. J Androl. 2000;21:303-310.
16. Ge RS, Dong Q, Sottas CM, Chen H, Zirkin BR, Hardy MP. Gene expression in rat Leydig cells during development from the progenitor to adult stage: a cluster analysis. Biol Reprod. 2005;72(6):1405-1415.
17. Davidoff M, Schulze, W. Combination of the peroxidase antiperoxidase (PAP)- and avidin- biotin- peroxidase complex (ABC)- techniques: An amplification alternative in immunocytochemical staining. Histochemistry. 1990;93:531-536.
18. Bremner WJ, Millar MR, Sharpe RM, Saunders PTK. Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Endocrinology. 1994;135(3):1227-1234.
19. Atanassova N, Koeva Y, Bakalska M, Pavlova E, Nikolov B, Davidoff M. Loss and recovery of androgen receptor protein expression in the adult rat testis following androgen withdrawal by ethane dimethanesulfonate. Folia Histochem Cytobiol. 2006;44(2):81-86.
20. Bakalska M, Atanassova N, Pavlova E, Koeva Y, Nikolov B. Morphological alterations in rat testis during aging. Acta Morphol et Anthropol. 2008;13:82-6.
21. Steiner RA, Bremner WJ, Clifton DK, Dorsa DM. Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat. Biol Reprod. 1984;31:251-8.
22. Chen H, Luo L, Zirkin BR. Leydig cell structure and function during aging. In: Payne AH, Hardy MP, Russell LD, eds. The Leydig cell. Cache River Press, Vienna, IL; 1996:221-30.
23. Levy S, Serre V, Hermo L, Robaire B. The effect of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat. J Androl. 1999;20:356-65.
24. Ichihara I, Kawamura H, Pelliniemi LJ. Ultrastructure and morphometry of testicular Leydig cells and the interstitial components correlated with testosterone in aging rats. Cell Tissue Res. 1993;271(2):241-55.
25. Wang C, Leung A, Sinha-Hikim A. Reproductive aging in the male Brown Norway rat: a model for the human. Endocrinology. 1993;133:2773-81.
26. Chen H, Hardy MP, Huhtaniemi I, Zirkin BR. Age-related decreased Leydig cell testosterone production in the Brown Norway rat. J Androl. 1994;15:551-57.
27. Luo L, Chen H, Zirkin BR. Are Leydig cell steroidogenic enzymes differentially regulated with aging? J Androl. 1996;17:509-515.
28. Monder C, White PC. 11 hydroxysteroid dehydrogenase. Vitam Horm. 1993;47:187-271.
29. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab. 1995;80:3155-59.
30. Hardy MP, Gao HB, Dong Q, et al. Stress hormone and male reproductive function. Cell Tissue Res. 2005;322(1):147-53.
31. Koeva Y, Bakalska M, Atanassova N, Georgieva K, Davidoff M. 11β hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats. Folia Histochem Cytobiol. 2007;45(4):381-6.
32. Ge RS, Dong Q, Nin EM, et al. 11 beta-hydroxysteroid dehydrogenase 2 in rat Leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate. Endocrinology. 2005;146(6):2657-2664.
33. Sankar BR, Maran RR, Subha S, Govindarajulu P, Balasubramanian K. Chronic corticosterone treatment impairs Leydig cell 11beta-hydroxysteroid dehydrogenase activity and LHstimulated testosterone production. Horm Metab Res. 2000;32(4):142-6.
34. Anand-Ivell RJ, Relan V, Balvers M, et al. Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis. Biol Reprod. 2006;74:945-953.
35. Ivell R and Bathgate R. Reproductive biology of the relaxin-like factor (RLF/INSL3). Biol Reprod. 2002;67:699-705.
36. Mendis- Handagama SM, Ariyaratne HB, Mrkonjich I, Ivell R. Expression of insulin-like peptide 3 in the postnatal Leydig cell lineage; timing and effects of triiodothyronine-treatment. Reproduction. 2007;133(2):479-85.
37. Foresta C, Bettella A, Vinanzi C, et al. A novel circulating hormone of testis origin in human. J Clin Endocrinol Metab. 2004;89:5952-8.
38. Sadeghian H, Anand-Ivell R, Balvers M, Relan V, Ivell R. Constitutive regulation of the Insl3 gene in rat Leydig cells. Mol Cell Endocrinol. 2005;124:10-20.
39. Paust HJ, Wessels J, Ivell R, Mukhopadhyay AK. The expression of RLF/INSL3 gene is reduced in Leydig cells of the aging rat testis. Exp Gerontol. 2002;37:1461-67.
40. Heinlein CA, Chang C. Androgen receptor (AR) coregulators: An overview. Endocr Rev. 2002;23:175-200.
41. Syed V, Hecht N. Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communications during aging in the Brown Norway rat. Biol Reprod. 2001;64:107-112.
42. Ivell R. Biology of the relaxin-like factor (RLF). Rev Reprod. 1997;2:133-138.