Selective loss of Sertoli cell and germ cell function leads to a disruption in Sertoli cell-germ cell communication during aging in the Brown Norway rat

Biology of Reproduction

Volumn 64, Issue 1, 2001, Pages 107-112

  Syed, V ^a   Hecht, N B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aging; Gene regulation; Sertoli cells; Spermatid; Spermatogenesis; Testis

Indexed keywords

MESSENGER RNA; SEROTONIN RECEPTOR;

AGING; ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL LOSS; COCULTURE; GENE INDUCTION; GERM CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SERTOLI CELL; TESTIS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0035159298     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod64.1.107     Document Type: Article

References (23)

1. Reproductive aging in the male Brown-Norway rat: A model for the human
2. Testicular steroidogenesis in the aging Brown Norway rat
3. The effect of aging on the seminiferous epithelium of the Brown Norway rat
4. Multinucleate Sertoli cells in aged human testis
5. Ultrastructural changes in Sertoli cells in aging humans
6. The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown NorWay rat
7. Quantification of the human Sertoli cell population: Its distribution, relation to germ cell numbers, and age-related decline
8. Increased germ cell degeneration during postprophase of meiosis is related to increased serum follicle-stimulating hormone concentrations and reduced daily sperm production in aged men
9. The central role of Sertoli cells in spermatogenesis
10. The Sertoli-germ cell communication network in mammals
11. Current aspects of autocrine and paracrine regulation of spermatogenesis
12. Paracrine control of spermatogenesis
13. A comparison of the effects of testicular maturation and aging on the stage-specific expression of CP-2/cathepsin L messenger ribonucleic acid by Sertoli cells of the Brown Norway rat
14. mRNAs encoding avon Ebner's-like protein and the Huntington disease protein are induced in rat male germ cells by Sertoli cells
15. Messenger ribonucleic acids encoding a serotonin receptor and a novel gene are induced in Sertoli cells by a secreted factor(s) from male rat meiotic germ cells
16. In vitro effects of germ cells on the secretory activity of Sertoli cells recovered from rats of different ages
17. Up-regulation and down-regulation of genes expressed in cocultures of rat Sertoli cells and germ cells
18. Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas Sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and methoxyacetic acid
19. Differences in regulation of testis specific lactate dehydrogenase in rat and mouse occur at multiple levels
20. A transferrin like (hemiferrin) mRNA is expressed in the germ cells of rat testis
21. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells
22. Decreased serum inhibin levels in normal elderly men: Evidence for a decline in Sertoli cell function with aging
23. Paternal age affects fertility and progeny outcome in the Brown Norway rat